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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Goldstein, Jill M. Cherkerzian, Sara Tsuang, Ming T. and Petryshen, Tracey L. 2013. Sex differences in the genetic risk for schizophrenia: History of the evidence for sex-specific and sex-dependent effects. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 162, Issue. 7, p. 698.
    Crow, Timothy J. 2013. The XY gene hypothesis of psychosis: Origins and current status. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 162, Issue. 8, p. 800.
    Ponnudurai, R. and Jayakar, J. 2010. Mode of transmission of schizophrenia. Asian Journal of Psychiatry, Vol. 3, Issue. 2, p. 67.
    SMALLEY, SUSAN L. McGOUGH, JAMES J. Del'HOMME, MELISSA NewDELMAN, JODIE GORDON, ELSIE KIM, TAE LIU, AMY and McCRACKEN, JAMES T. 2000. Familial Clustering of Symptoms and Disruptive Behaviors in Multiplex Families With Attention-Deficit/Hyperactivity Disorder. Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 39, Issue. 9, p. 1135.
    Dupuis, Josée and Van Eerdewegh, Paul 2000. Multipoint Linkage Analysis of the Pseudoautosomal Regions, Using Affected Sibling Pairs. The American Journal of Human Genetics, Vol. 67, Issue. 2, p. 462.
    Riley, Brien P. and McGuffin, Peter 2000. Linkage and associated studies of schizophrenia. American Journal of Medical Genetics, Vol. 97, Issue. 1, p. 23.
    Lopes-Machado, E.Z. and Duarte, F.A.M. 2000. Localization of genes modulating the predisposition to schizophrenia: a revision. Genetics and Molecular Biology, Vol. 23, Issue. 3, p. 549.
    Prior, Trevor I. Chue, Pierre S. and Tibbo, Philip 2000. Investigation of Turner syndrome in schizophrenia. American Journal of Medical Genetics, Vol. 96, Issue. 3, p. 373.
    Delisi, Lynn E. 1997. The genetics of schizophrenia: past, present, and future concepts. Schizophrenia Research, Vol. 28, Issue. 2-3, p. 163.
    Dann, Janine DeLisi, Lynn E Devoto, Marcella Laval, Steven Nancarrow, Derek J Shields, Gail Smith, Angela Loftus, Josephine Peterson, Paula Vita, Antonio Comazzi, Margherita Invernizzi, Giordano Levinson, Douglas F Wildenauer, Dieter Mowry, Bryan J Collier, David Powell, John Crowe, Raymond R Andreasen, Nancy C Silverman, Jeremy M Mohs, Richard C Murray, Robin M Walters, Marilyn K Lennon, David P Hayward, Nicholas K Albus, Margot Lerer, Bernard Maier, Wolfgang and Crow, Timothy J 1997. A linkage study of schizophrenia to markers within Xp11 near the MAOB gene. Psychiatry Research, Vol. 70, Issue. 3, p. 131.
    Ponnudurai, R. 1996. Failure to support a pseudoautosomal locus for schizophrenia. Psychiatry Research, Vol. 62, Issue. 3, p. 281.
    Murphy, Kieran C. Cardno, Alastair G. and McGuffin, Peter 1996. The molecular genetics of schizophrenia. Journal of Molecular Neuroscience, Vol. 7, Issue. 2, p. 147.
    Kalsi, Gursharan Curtis, David Brynjolfsson, Jon Butler, Robert Sharma, Tonmoy Murphy, Patrice Read, Tim Petursson, Hannes and Gurling, Hugh M. D. 1995. Investigation by Linkage Analysis of the XY Pseudoautosomal Region in the Genetic Susceptibility to Schizophrenia. British Journal of Psychiatry, Vol. 167, Issue. 03, p. 390.
    Pulver, Ann E. Lasseter, Virginia K. Kasch, Laura Wolyniec, Paula Nestadt, Gerald Blouin, Jean-Louis Kimberland, Michelle Babb, Robert Vourlis, Sophia Chen, Haiming Lalioti, Maria Morris, Michael A. Karayiorgou, Maria Ott, Jurg Meyers, Deborah Antonarakis, Stylianos E. Housman, David and Kazazian, Haig H. 1995. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. American Journal of Medical Genetics, Vol. 60, Issue. 3, p. 252.
    Arranz, Maria Sharma, Tonmoy Sham, Pak Kerwin, Robert Nanko, Shin Owen, Michael Gill, Michael and Collier, David 1995. Schizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with reifenstein syndrome but no evidence for linkage in 23 multiply affected families. American Journal of Medical Genetics, Vol. 60, Issue. 5, p. 377.
    Maier, Wolfgang Schmidt, Friedrich Schwab, Sibylle G. Hallmayer, Joachim Minges, Jürgen Ackenheil, Manfred Lichtermann, Dirk and Wildenauer, Dieter B. 1995. Lack of linkage between schizophrenia and markers at the telomeric end of the pseudoautosomal region of the sex chromosomes. Biological Psychiatry, Vol. 37, Issue. 5, p. 344.
    Okoro, Christabella Bell, Rachel Sham, Pak Nanko, Shin Asherson, Philip Owen, Michael Gill, Michael McGuffin, Peter Murray, Robin M. and Collier, David 1995. No evidence for linkage between the X-chromosome marker DXS7 and schizophrenia. American Journal of Medical Genetics, Vol. 60, Issue. 5, p. 461.
    Franzek, Ernst Schmidtke, Armin Beckmann, Helmut and Stöber, Gerald 1995. Evidence against unusual sex concordance and pseudoautosomal inheritance in the catatonic subtype of schizophrenia. Psychiatry Research, Vol. 59, Issue. 1-2, p. 17.
    Baron, M. 1995. Genes and psychosis: old wine in new bottles?. Acta Psychiatrica Scandinavica, Vol. 92, Issue. 2, p. 81.
    Aschauer, Harald N. Meszaros, Kurt Willinger, Ulrike Fischer, Gabriele Strobl, Rainer Beran, Henriette Lenzinger, Elisabeth Reiter, Eleonore and Heiden, Angela M. 1994. Non-concordance by gender for schizophrenia and related disorders in sibships. European Archives of Psychiatry and Clinical Neuroscience, Vol. 244, Issue. 1, p. 12.
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No Evidence for a Pseudoautosomal Locus for Schizophrenia: Linkage Analysis of Multiply Affected Families

  • P. Asherson (a1), E. Parfitt (a2), M. Sargeant (a3), S. Tidmarsh (a4), P. Buckland (a4), C. Taylor (a5), A. Clements (a6), M. Gill (a6), P. Mcguffin (a4) and M. Owen (a7)...
Abstract

Evidence for a pseudoautosomal locus for a schizophrenia susceptibility gene was sought by two forms of analysis of 25 multiply affected families. Firstly, in the sample as a whole there was an excess of same-sex over mixed-sex siblings compared with that expected. Secondly, linkage analysis was performed in six of the families. The genotypes were studied for DXYS14, a highly polymorphic marker in the telomeric pseudoautosomal region. No evidence for positive linkage was found with two-point analysis under eight different genetic models for the mode of transmission. A non-parametric, sibling-pair analysis also failed to detect linkage. Our findings provide no evidence for linkage within the pseudoautosomal region; same-sex concordance must arise from some other mechanism.

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COPYRIGHT: © 1992 The Royal College of Psychiatrists 
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References
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Clerget-Darpoux, F. (1991) The uses and abuses of linkage analysis in neuropsychiatric disorder. In The New Genetics of Mental Illness (eds McGuffin, P. & Murray, R.), pp. 44–57, Oxford: Butterworth
Collinge, J. S. Delisi, L. E., Boccio, A., et al (1991) Evidence for a pseudoautosomal locus for schizophrenia using the method of Affected Sibling Pairs. British Journal of Psychiatry, 158, 624–629.
Cooke, H. J., Brown, R. A. & Rappold, G. A. (1985) Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal. Nature, 317, 687–692.
Crow, T. J. (1988) Sex chromosomes and psychosis. The case for a pseudoautosomal locus. British Journal of Psychiatry, 153, 675–683.
Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1989) Concordance by sex in sibling pairs with schizophrenia is paternally inherited: evidence for a pseudoautosomal locus. British Journal of Psychiatry, 155, 92–97.
Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1990) In reply … a locus closer to the telomere? British Journal of Psychiatry, 156, 416–420.
Curtis, D. & Gurling, H. (1990) Unsound methodology in investigating a pseudoautosomal locus in schizophrenia. British Journal of Psychiatry, 156, 415–416.
Gill, M., McGuffin, P. & Parfitt, E. (1992) A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Psychological Medicine (in press).
Gottesman, I. I. & Shields, J. (1982) Schizophrenia: the Epigenetic Puzzle. Cambridge: Cambridge University Press.
Green, J. R. & Woodrow, J. C. (1977) Sibling method for detecting HLA linked genes in diseases. Tissue Antigens, 9, 31–35.
Kunkel, L. M., Smith, K. D., Boyer, S. H., et al (1977) Analysis of human Y chromosome variants. Proceedings of the National Academy of Sciences USA, 74, 1245–1249.
Lathrop, G. M., Lalouel, J. M., Julier, C., et al (1984) Strategies for multilocus linkage analysis in humans. Proceedings of the National Academy of Sciences USA, 81, 3443–3446.
McGuffin, P. (1988) Genetics of schizophrenia. In Schizophrenia, the Major Issues (eds Bebbington, P. & McGuffin, P.), pp. 107–126. London: Heinemann.
McGuffin, P., Festenstein, H. & Murray, R. (1983) A family study of HLA and other genetic markers in schizophrenia. Psychological Medicine, 13, 31–43.
McGuffin, P., Katz, R. & Aldrich, J. (1986) Past and present state examination: the assessment of ‘lifetime ever’ psychology. Psychological Medicine, 16, 4461–4465.
McGuffin, P., Farmer, A., Harvey, I., et al (1991) A polydiagnostic application of operational criteria in studies of psychotic illness. Archives of General Psychiatry, 48, 764–770.
McGue, M. & Gottesman, I. I. (1989) Genetic linkage in schizophrenia: perspectives from genetic epidemiology. Schizophrenia Bulletin, 15, 453–464.
Morton, N. E. (1955) Sequential tests for the detection of linkage. American Journal of Human Genetics, 7, 277–318.
O'Rourke, D. H., Gottesman, I. I., Suarez, B. K., et al (1982) Refutation of the single locus model in the aetiology of schizophrenia. American Journal of Human Genetics, 33, 630–649.
Ott, J. (1985) Analysis of Human Genetic Linkage. Baltimore: Johns Hopkins University Press.
Ott, J. (1991) Analysis of Human Genetic Linkage (2nd edn). Baltimore: Johns Hopkins University Press.
Page, D. C., Bieker, K., Brown, L. G., et al (1987) Linkage, physical mapping and DNA sequence analysis of pseudoautosomal loci on the human X and Y chromosomes. Genomics, 1, 243–256.
Penrose, L. S. (1945) Survey of cases of familial mental illness. Reproduced (1991), European Archives of Psychiatry and Clinical Neuroscience, 240, 315–324.
Risch, N. (1991) A note on multiple testing procedures in linkage analysis. American Journal of Human Genetics, 48, 1058–1064.
Sandkuhl, L. A. (1989) Analysis of affected sib pairs using information from extended families. Progress in Biological Research, 392, 117–122.
Schulz, B. (1932) Zur Erbpathologie der Schizophreniae. Zeitschrift fur die Gesammte Neurologie und Psychiatriae, 143, 175–293.
Southern, E. M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology, 98, 503–517.
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria for a Selected Group of Functional Disorders (3rd edn). New York: New York State Psychiatric Institute.
Sturt, E. & Shur, E. (1985) Sex concordance for schizophrenia in proband–rdative pairs. British Journal of Psychiatry, 147, 44–47.
Sturt, E. & McGuffin, P. (1985) Can linkage and marker association resolve the genetic aetiology of psychiatric disorders: review and argument. Psychological Medicine, 15, 455–462.
Suarez, B. K. & van Eerdewegh, P. (1984) A comparison of three affected sib-pair methods to detect HLA-linked disease susceptibility genes. American Journal of Human Genetics, 18, 135–146.
Tsuang, M. T. (1967) A study of pairs of siblings both hospitalised for mental disorders. British Journal of Psychiatry, 113, 283–300.
von Zehnder, M. (1941) Uber Krankheitsbild und Krankheitsverlauf bei schizophrenen Geschwistern. Monatsschrift fur Psychiatrie und Neurologie, 103, 231–277.
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) Description and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.
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  • Cited by 30
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Goldstein, Jill M. Cherkerzian, Sara Tsuang, Ming T. and Petryshen, Tracey L. 2013. Sex differences in the genetic risk for schizophrenia: History of the evidence for sex-specific and sex-dependent effects. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 162, Issue. 7, p. 698.
    Crow, Timothy J. 2013. The XY gene hypothesis of psychosis: Origins and current status. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 162, Issue. 8, p. 800.
    Ponnudurai, R. and Jayakar, J. 2010. Mode of transmission of schizophrenia. Asian Journal of Psychiatry, Vol. 3, Issue. 2, p. 67.
    SMALLEY, SUSAN L. McGOUGH, JAMES J. Del'HOMME, MELISSA NewDELMAN, JODIE GORDON, ELSIE KIM, TAE LIU, AMY and McCRACKEN, JAMES T. 2000. Familial Clustering of Symptoms and Disruptive Behaviors in Multiplex Families With Attention-Deficit/Hyperactivity Disorder. Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 39, Issue. 9, p. 1135.
    Dupuis, Josée and Van Eerdewegh, Paul 2000. Multipoint Linkage Analysis of the Pseudoautosomal Regions, Using Affected Sibling Pairs. The American Journal of Human Genetics, Vol. 67, Issue. 2, p. 462.
    Riley, Brien P. and McGuffin, Peter 2000. Linkage and associated studies of schizophrenia. American Journal of Medical Genetics, Vol. 97, Issue. 1, p. 23.
    Lopes-Machado, E.Z. and Duarte, F.A.M. 2000. Localization of genes modulating the predisposition to schizophrenia: a revision. Genetics and Molecular Biology, Vol. 23, Issue. 3, p. 549.
    Prior, Trevor I. Chue, Pierre S. and Tibbo, Philip 2000. Investigation of Turner syndrome in schizophrenia. American Journal of Medical Genetics, Vol. 96, Issue. 3, p. 373.
    Delisi, Lynn E. 1997. The genetics of schizophrenia: past, present, and future concepts. Schizophrenia Research, Vol. 28, Issue. 2-3, p. 163.
    Dann, Janine DeLisi, Lynn E Devoto, Marcella Laval, Steven Nancarrow, Derek J Shields, Gail Smith, Angela Loftus, Josephine Peterson, Paula Vita, Antonio Comazzi, Margherita Invernizzi, Giordano Levinson, Douglas F Wildenauer, Dieter Mowry, Bryan J Collier, David Powell, John Crowe, Raymond R Andreasen, Nancy C Silverman, Jeremy M Mohs, Richard C Murray, Robin M Walters, Marilyn K Lennon, David P Hayward, Nicholas K Albus, Margot Lerer, Bernard Maier, Wolfgang and Crow, Timothy J 1997. A linkage study of schizophrenia to markers within Xp11 near the MAOB gene. Psychiatry Research, Vol. 70, Issue. 3, p. 131.
    Ponnudurai, R. 1996. Failure to support a pseudoautosomal locus for schizophrenia. Psychiatry Research, Vol. 62, Issue. 3, p. 281.
    Murphy, Kieran C. Cardno, Alastair G. and McGuffin, Peter 1996. The molecular genetics of schizophrenia. Journal of Molecular Neuroscience, Vol. 7, Issue. 2, p. 147.
    Kalsi, Gursharan Curtis, David Brynjolfsson, Jon Butler, Robert Sharma, Tonmoy Murphy, Patrice Read, Tim Petursson, Hannes and Gurling, Hugh M. D. 1995. Investigation by Linkage Analysis of the XY Pseudoautosomal Region in the Genetic Susceptibility to Schizophrenia. British Journal of Psychiatry, Vol. 167, Issue. 03, p. 390.
    Pulver, Ann E. Lasseter, Virginia K. Kasch, Laura Wolyniec, Paula Nestadt, Gerald Blouin, Jean-Louis Kimberland, Michelle Babb, Robert Vourlis, Sophia Chen, Haiming Lalioti, Maria Morris, Michael A. Karayiorgou, Maria Ott, Jurg Meyers, Deborah Antonarakis, Stylianos E. Housman, David and Kazazian, Haig H. 1995. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. American Journal of Medical Genetics, Vol. 60, Issue. 3, p. 252.
    Arranz, Maria Sharma, Tonmoy Sham, Pak Kerwin, Robert Nanko, Shin Owen, Michael Gill, Michael and Collier, David 1995. Schizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with reifenstein syndrome but no evidence for linkage in 23 multiply affected families. American Journal of Medical Genetics, Vol. 60, Issue. 5, p. 377.
    Maier, Wolfgang Schmidt, Friedrich Schwab, Sibylle G. Hallmayer, Joachim Minges, Jürgen Ackenheil, Manfred Lichtermann, Dirk and Wildenauer, Dieter B. 1995. Lack of linkage between schizophrenia and markers at the telomeric end of the pseudoautosomal region of the sex chromosomes. Biological Psychiatry, Vol. 37, Issue. 5, p. 344.
    Okoro, Christabella Bell, Rachel Sham, Pak Nanko, Shin Asherson, Philip Owen, Michael Gill, Michael McGuffin, Peter Murray, Robin M. and Collier, David 1995. No evidence for linkage between the X-chromosome marker DXS7 and schizophrenia. American Journal of Medical Genetics, Vol. 60, Issue. 5, p. 461.
    Franzek, Ernst Schmidtke, Armin Beckmann, Helmut and Stöber, Gerald 1995. Evidence against unusual sex concordance and pseudoautosomal inheritance in the catatonic subtype of schizophrenia. Psychiatry Research, Vol. 59, Issue. 1-2, p. 17.
    Baron, M. 1995. Genes and psychosis: old wine in new bottles?. Acta Psychiatrica Scandinavica, Vol. 92, Issue. 2, p. 81.
    Aschauer, Harald N. Meszaros, Kurt Willinger, Ulrike Fischer, Gabriele Strobl, Rainer Beran, Henriette Lenzinger, Elisabeth Reiter, Eleonore and Heiden, Angela M. 1994. Non-concordance by gender for schizophrenia and related disorders in sibships. European Archives of Psychiatry and Clinical Neuroscience, Vol. 244, Issue. 1, p. 12.
    Download full list
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  • Get access
    Add to cart USD35.00
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No Evidence for a Pseudoautosomal Locus for Schizophrenia: Linkage Analysis of Multiply Affected Families

  • P. Asherson (a1), E. Parfitt (a2), M. Sargeant (a3), S. Tidmarsh (a4), P. Buckland (a4), C. Taylor (a5), A. Clements (a6), M. Gill (a6), P. Mcguffin (a4) and M. Owen (a7)...
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