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Paternal age at birth and high-functioning autistic-spectrum disorder in offspring

  • Kenji J. Tsuchiya (a1), Kaori Matsumoto (a2), Taishi Miyachi (a2), Masatsugu Tsujii (a3), Kazuhiko Nakamura (a4), Shu Takagai (a4), Masayoshi Kawai (a4), Atsuko Yagi (a4), Kimie Iwaki (a4), Shiro Suda (a4), Genichi Sugihara (a2), Yasuhide Iwata (a4), Hideo Matsuzaki (a2), Yoshimoto Sekine (a4), Katsuaki Suzuki (a4), Toshirou Sugiyama (a5), Norio Mori (a4) and Nori Takei (a6)...

Abstract

Background

Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability.

Aims

To test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability).

Method

A case–control study was conducted in Japan. The participants consisted of individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order.

Results

Eighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates.

Conclusions

Advanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.

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Copyright

Corresponding author

Nori Takei, Osaka Hamamatsu Joint Research Center for Child Mental Development (OHJRC–CMD), Hamamatsu University School of Medicine, Handayama 1 Higashiku, Hamamatsu 431-3192, Japan. Email: ntakei@hama-med.ac.jp

References

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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Paternal age at birth and high-functioning autistic-spectrum disorder in offspring

  • Kenji J. Tsuchiya (a1), Kaori Matsumoto (a2), Taishi Miyachi (a2), Masatsugu Tsujii (a3), Kazuhiko Nakamura (a4), Shu Takagai (a4), Masayoshi Kawai (a4), Atsuko Yagi (a4), Kimie Iwaki (a4), Shiro Suda (a4), Genichi Sugihara (a2), Yasuhide Iwata (a4), Hideo Matsuzaki (a2), Yoshimoto Sekine (a4), Katsuaki Suzuki (a4), Toshirou Sugiyama (a5), Norio Mori (a4) and Nori Takei (a6)...
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