Skip to main content
×
×
Home

Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

  • J. E. Christie (a1), A. Shering (a1), J. Ferguson (a1) and A. I. M. Glen (a1)
Summary

Physostigmine (0.25 mg-1 mg), arecoline (2 and 4 mg) and saline were administered intravenously over 30 minutes in a randomized double blind design to 11 patients with a clinical diagnosis of Alzheimer presenile dementia. Significant improvement was seen on a picture recognition test with physostigmine 0.375 mg and arecholine 4 mg. A trend towards improvement was also seen with physostigmine 0.25 mg and 0.75 mg, and arecholine 2 mg. For the majority of the patients improvement was only slight but in two patients it was clear cut and consistent.

Copyright
References
Hide All
Bartus, R. T. (1978) Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: effects of concurrent administration of physostigmine and methylphenidate with scopolamine. Pharmacology, Biochemistry and Behaviour, 9, 833836.
Bartus, R. T. (1979) Physostigmine and recent memory: effects in young and aged nonhuman primates. Science, 206, 10871089.
Blessed, G. Tomlinson, B. E. & Roth, M. (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797811.
Boyd, W. D. Graham-White, J. Blackwood, G. Glen, I. & McQueen, J. (1977) Clinical effects of choline in Alzheimer senile dementia. The Lancet, ii, 711.
Buschke, H. (1973) Selective reminding for analysis of memory and learning. Journal of Verbal Learning, Verbal Behavior, 12, 543550.
Christie, J. E. Blackburn, I. M. Glen, A. I. M. Zeisel, S. Shering, A. & Yates, C. M. (1979) Effects of choline and lecithin on CSF choline levels and on cognitive function in patients with presenile dementia of the Alzheimer type. In: Nutrition and the Brain, vol. 5 (eds. Barbeau, A. Growdon, J. H. and Wurtman, R. J.), pp 377387. New York: Raven Press.
Crow, T. J. & Grove-White, I. (1973) An analysis of the learning deficit following hyoscine on human learning capacity. British Journal of Pharmacology, 49, 322327.
Davies, P. & Maloney, A. J. F. (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. The Lancet, ii, 1403.
Davies, P. & Verth, A. H. (1978) Regional distribution of muscarinic acetylcholine receptors in normal and Alzheimer type dementia brains. Brain Research, 138, 385392.
Davis, K. L. & Berger, P. A. (1978) Pharmacological investigations of the cholinergic imbalance hypothesis of movement disorders and psychosis. Biological Psychiatry, 13, 2349.
Davis, K. L. Mohs, R. Tinklenberg, J. R. Pfefferbaum, A. Hollister, L. E. & Kopell, B. S. (1978) Physostigmine: improvement of long term memory processes in normal humans. Science, 201, 272273.
Deutsch, J. A. (1971) The cholinergic synapse and the site of memory. Science, 174, 788794.
Deutsch, J. A. (1979) Physiology of acetylcholine in learning and memory. In: Nutrition and The Brain, vol. 5 (eds. Barbeau, A. Growdon, J. H. and Wurtman, R. J.), pp 343350. New York: Raven Press.
Drachman, D. (1977) Memory and cognitive function in man: does the cholinergic system have a specific role? Neurology, 27, 783790.
Drachman, D. & Leavitt, J. (1974) Human memory and the cholinergic system: a relationship to aging. Archives of Neurology, 15, 5261.
Drachman, D. & Sahakian, B. J. (1979) Effect of cholinergic agents on human learning and memory. In: Nutrition and The Brain, vol. 5 (eds. Barbeau, A. Growdon, J. H. and Wurtman, R. J.), pp 351366. New York: Raven Press.
Etienne, P. Gauthier, S. Johnson, G. Collier, B. Mendis, T. Dastoor, D. Cole, M. & Muller, H. F. (1978) Clinical effects of choline in Alzheimer's disease. The Lancet, i, 508509.
Glen, A. I. M. & Christie, J. E. (1979) Early diagnosis of Alzheimer's disease: working definitions for clinical and laboratory criteria. In: Alzheimer's Disease: Early Recognition of Potentially Reversible Deficits (eds. Glen, A. I. M. and Whalley, L. J.), pp 122128. Edinburgh: Churchill Livingstone.
Mohs, R. C. & Davis, K. L. (1979) Cholinomimetic drug effects on memory in young and elderly adults. In: Alzheimer's Disease: Early Recognition of Potentially Reversible Deficits (eds. Glen, A. I. M. and Whalley, L. J.), pp 154158. Edinburgh: Churchill Livingstone.
Ostfeld, A. & Aruguete, A. (1962) Central nervous system effects of hyoscine in man. Journal of Pharmacology and Experimental Therapeutics, 137, 133139.
Perry, E. K. Gibson, P. H. Blessed, G. Perry, R. H. & Tomlinson, B. E. (1977) Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyl-transferase and glutamic acid decarboxylase activities in necropsy brain tissue. Journal of the Neurological Sciences, 34, 247265.
Perry, E. K. Tomlinson, B. E. Blessed, G. Bergmann, K. Gibson, P. H. & Perry, R. H. (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. British Medical Journal, ii, 14571459.
Petersen, R. (1977) Scopolamine induced learning failures in man. Psychopharmacology, 52, 283289.
Shepard, R. N. (1967) Recognition memory for words, sentences and pictures. Journal of Verbal Learning Behaviour, 6, 156163.
Signoret, J. L. Whiteley, A. & Lhermitte, F. (1978) Influence of choline on amnesia in early Alzheimer's disease. The Lancet, ii, 837.
Sitaram, N. Weingartner, H. & Gelling, J. C. (1978a) Human serial learning: enhancement with arecoline and choline and impairment with scopolamine. Science, 201, 274.
Sitaram, N. Weingartner, H. Calne, E. & Gilling, J. C. (1978b) Choline: selective enhancement of serial learning and encoding of low imagery words in man. Life Science, 22, 1555.
Smith, C. M. & Swash, M. (1978) Possible biochemical basis of memory disorder in Alzheimer's disease. Annals of Neurology, 3, 471473.
White, P. Goodhardt, M. J. Keet, J. P. Hiley, C. R. Carrasco, L. H. Williams, I. E. I. & Bowen, D. M. (1977) Neocortical cholinergic neurons in elderly people. The Lancet, i, 668670.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

  • J. E. Christie (a1), A. Shering (a1), J. Ferguson (a1) and A. I. M. Glen (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *