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Platelet Monoamine Oxidase Activity in Acute Schizophrenia: Relationship to Symptomatology and Neuroleptic Medication

Published online by Cambridge University Press:  29 January 2018

Frank Owen ,
Rachel C. Bourne ,
Timothy J. Crow ,
Eve C. Johnstone  and
Adnam A. Fadhli
Frank Owen
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
Rachel C. Bourne
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
Timothy J. Crow
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
Eve C. Johnstone
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
Adnam A. Fadhli
Affiliation:
Division of Psychiatry, College of Medicine, Baghdad, Iraq
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Summary

Platelet MAO activity was assessed in 35 schizophrenics during a trial of the isomers of flupenthixol. Enzyme activity was unrelated to severity of symptoms, the presence of delusions, hallucinations or thought disorder or to negative symptoms. In a few patients MAO activity fluctuated widely with time, but in the group of patients on medication there was a slow decrease in enzyme activity which was significant after 28 days of treatment. Enzyme activity after 14 days' drug treatment was still correlated with activity before treatment, but after 28 days this significant correlation disappeared. Slow effects of neuroleptic drugs on platelet MAO activity may explain previous findings of reduced activity of the enzyme in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 139 , Issue 1 , July 1981 , pp. 16 - 22
Copyright
Copyright © The Royal College of Psychiatrists 

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