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  • Cited by 55
  • Cited by
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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Mistry, Sumit Escott-Price, Valentina Florio, Arianna D. Smith, Daniel J. and Zammit, Stanley 2019. Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood. Journal of Affective Disorders, Vol. 246, Issue. , p. 633.
    Hartmann, Jessica A Nelson, Barnaby Ratheesh, Aswin Treen, Devi and McGorry, Patrick D 2019. At-risk studies and clinical antecedents of psychosis, bipolar disorder and depression: a scoping review in the context of clinical staging. Psychological Medicine, Vol. 49, Issue. 02, p. 177.
    Duffy, Anne Keown‐Stoneman, Charles DG Goodday, Sarah M Saunders, Katharine Horrocks, Julie Grof, Paul Weir, Arielle Hinds, Chris and Geddes, John 2018. Daily and weekly mood ratings using a remote capture method in high‐risk offspring of bipolar parents: Compliance and symptom monitoring. Bipolar Disorders,
    Hafeman, Danella M. and Birmaher, Boris 2018. Bipolar Disorder Vulnerability. p. 1.
    Marangoni, Ciro Faedda, Gianni L. and Baldessarini, Ross J. 2018. Clinical and Environmental Risk Factors for Bipolar Disorder. Harvard Review of Psychiatry, Vol. 26, Issue. 1, p. 1.
    Marwaha, Steven Winsper, Catherine Bebbington, Paul and Smith, Daniel 2018. Cannabis Use and Hypomania in Young People: A Prospective Analysis. Schizophrenia Bulletin, Vol. 44, Issue. 6, p. 1267.
    Ratheesh, Aswin Cotton, Susan M. Davey, Christopher G. Lin, Ashleigh Wood, Stephen Yuen, Hok Pan Bechdolf, Andreas McGorry, Patrick D. Yung, Alison Berk, Michael and Nelson, Barnaby 2018. Pre-onset risk characteristics for mania among young people at clinical high risk for psychosis. Schizophrenia Research, Vol. 192, Issue. , p. 345.
    Birmaher, Boris Merranko, John A. Goldstein, Tina R. Gill, Mary Kay Goldstein, Benjamin I. Hower, Heather Yen, Shirley Hafeman, Danella Strober, Michael Diler, Rasim S. Axelson, David Ryan, Neal D. and Keller, Martin B. 2018. A Risk Calculator to Predict the Individual Risk of Conversion From Subthreshold Bipolar Symptoms to Bipolar Disorder I or II in Youth. Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 57, Issue. 10, p. 755.
    Goetz, Michal Mohaplova, Marketa Sebela, Antonin and Novak, Tomas 2018. Understanding Uniqueness and Diversity in Child and Adolescent Mental Health. p. 25.
    Malhi, Gin S Morris, Grace Hamilton, Amber Outhred, Tim and Mannie, Zola 2017. Is “early intervention” in bipolar disorder what it claims to be?. Bipolar Disorders, Vol. 19, Issue. 8, p. 627.
    Mesman, E. Youngstrom, E.A. Juliana, N.K. Nolen, W.A. and Hillegers, M.H.J. 2017. Validation of the Seven Up Seven Down Inventory in bipolar offspring: screening and prediction of mood disorders. Findings from the Dutch Bipolar Offspring Study. Journal of Affective Disorders, Vol. 207, Issue. , p. 95.
    Duffy, A. Patten, S. Goodday, S. Weir, A. Heffer, N. and Cipriani, A. 2017. Efficacy and tolerability of lithium in treating acute mania in youth with bipolar disorder: protocol for a systematic review. International Journal of Bipolar Disorders, Vol. 5, Issue. 1,
    Papachristou, Efstathios Oldehinkel, Albertine J. Ormel, Johan Raven, Dennis Hartman, Catharina A. Frangou, Sophia and Reichenberg, Abraham 2017. The predictive value of childhood subthreshold manic symptoms for adolescent and adult psychiatric outcomes. Journal of Affective Disorders, Vol. 212, Issue. , p. 86.
    Pössel, Patrick and Meyer, Thomas D. 2017. Handbook of Social Behavior and Skills in Children. p. 363.
    Mesman, E. Nolen, W. A. Keijsers, L. and Hillegers, M. H. J. 2017. Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study. Acta Psychiatrica Scandinavica, Vol. 136, Issue. 2, p. 201.
    Pfennig, A. Ritter, P. S. Höfler, M. Lieb, R. Bauer, M. Wittchen, H.-U. and Beesdo-Baum, K. 2016. Symptom characteristics of depressive episodes prior to the onset of mania or hypomania. Acta Psychiatrica Scandinavica, Vol. 133, Issue. 3, p. 196.
    Fonseca-Pedrero, Eduardo Ortuño-Sierra, Javier Paino, Mercedes and Muñiz, José 2016. Detección del riesgo para los trastornos del espectro bipolar: evidencias de validez del Mood Disorder Questionnaire en adolescentes y adultos jóvenes. Revista de Psiquiatría y Salud Mental, Vol. 9, Issue. 1, p. 4.
    Klimes-Dougan, Bonnie Kennedy, Kevin P. and Cullen, Kathryn R. 2016. Developmental Psychopathology. p. 1.
    Fonseca-Pedrero, Eduardo Ortuño-Sierra, Javier Paino, Mercedes and Muñiz, José 2016. Screening the risk of bipolar spectrum disorders: Validity evidence of the Mood Disorder Questionnaire in adolescents and young adults. Revista de Psiquiatría y Salud Mental (English Edition), Vol. 9, Issue. 1, p. 4.
    Hunt, Jeffrey Schwarz, Charlotte M. Nye, Paul and Frazier, Elisabeth 2016. Is There a Bipolar Prodrome Among Children and Adolescents?. Current Psychiatry Reports, Vol. 18, Issue. 4,
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Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study

  • Marijn J. A. Tijssen (a1), Jim van Os (a2), Hans-Ulrich Wittchen (a3), Roselind Lieb (a4), Katja Beesdo (a5), Ron Mengelers (a1) and Marieke Wichers (a1)...
Abstract
Background

Although (hypo)manic symptoms are common in adolescence, transition to adult bipolar disorder is infrequent.

Aims

To examine whether the risk of transition to bipolar disorder is conditional on the extent of persistence of subthreshold affective phenotypes.

Method

In a 10-year prospective community cohort study of 3021 adolescents and young adults, the association between persistence of affective symptoms over 3 years and the 10-year clinical outcomes of incident DSM–IV (hypo)manic episodes and incident use of mental healthcare was assessed.

Results

Transition to clinical outcome was associated with persistence of symptoms in a dose-dependent manner. Around 30–40% of clinical outcomes could be traced to prior persistence of affective symptoms.

Conclusions

In a substantial proportion of individuals, onset of clinical bipolar disorder may be seen as the poor outcome of a developmentally common and usually transitory non-clinical bipolar phenotype.

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Copyright
COPYRIGHT: © Royal College of Psychiatrists, 2010 
Corresponding author
Marieke Wichers, Department of Psychiatry and Psychology, Maastricht University Medical Centre, PO Box 616 (Vijverdal), 6200 MD Maastricht, The Netherlands. Email: m.wichers@sp.unimaas.nl
Footnotes
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†

See pp. 87–88, this issue.

This work is part of the Early Developmental Stages of Psychopathology (EDSP) Study. The EDSP-Study is funded by the German Federal Ministry of Education and Research (BMBF; project no. 01EB9405/6, 01EB 9901/6, EB01016200, 01EB0140, and 01EB0440). Part of the field work and analyses were also additionally supported by grants of the Deutsche Forschungsgemeinschaft (DFG; project no. LA1148/1-1, WI2246/1-1, WI 709/7-1, and WI 709/8-1). M.W. was supported by the Dutch Medical Council (VENI grant number 916.76.147).

Declaration of interest

None.

Footnotes
References
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  • Cited by 55
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Mistry, Sumit Escott-Price, Valentina Florio, Arianna D. Smith, Daniel J. and Zammit, Stanley 2019. Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood. Journal of Affective Disorders, Vol. 246, Issue. , p. 633.
    Hartmann, Jessica A Nelson, Barnaby Ratheesh, Aswin Treen, Devi and McGorry, Patrick D 2019. At-risk studies and clinical antecedents of psychosis, bipolar disorder and depression: a scoping review in the context of clinical staging. Psychological Medicine, Vol. 49, Issue. 02, p. 177.
    Duffy, Anne Keown‐Stoneman, Charles DG Goodday, Sarah M Saunders, Katharine Horrocks, Julie Grof, Paul Weir, Arielle Hinds, Chris and Geddes, John 2018. Daily and weekly mood ratings using a remote capture method in high‐risk offspring of bipolar parents: Compliance and symptom monitoring. Bipolar Disorders,
    Hafeman, Danella M. and Birmaher, Boris 2018. Bipolar Disorder Vulnerability. p. 1.
    Marangoni, Ciro Faedda, Gianni L. and Baldessarini, Ross J. 2018. Clinical and Environmental Risk Factors for Bipolar Disorder. Harvard Review of Psychiatry, Vol. 26, Issue. 1, p. 1.
    Marwaha, Steven Winsper, Catherine Bebbington, Paul and Smith, Daniel 2018. Cannabis Use and Hypomania in Young People: A Prospective Analysis. Schizophrenia Bulletin, Vol. 44, Issue. 6, p. 1267.
    Ratheesh, Aswin Cotton, Susan M. Davey, Christopher G. Lin, Ashleigh Wood, Stephen Yuen, Hok Pan Bechdolf, Andreas McGorry, Patrick D. Yung, Alison Berk, Michael and Nelson, Barnaby 2018. Pre-onset risk characteristics for mania among young people at clinical high risk for psychosis. Schizophrenia Research, Vol. 192, Issue. , p. 345.
    Birmaher, Boris Merranko, John A. Goldstein, Tina R. Gill, Mary Kay Goldstein, Benjamin I. Hower, Heather Yen, Shirley Hafeman, Danella Strober, Michael Diler, Rasim S. Axelson, David Ryan, Neal D. and Keller, Martin B. 2018. A Risk Calculator to Predict the Individual Risk of Conversion From Subthreshold Bipolar Symptoms to Bipolar Disorder I or II in Youth. Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 57, Issue. 10, p. 755.
    Goetz, Michal Mohaplova, Marketa Sebela, Antonin and Novak, Tomas 2018. Understanding Uniqueness and Diversity in Child and Adolescent Mental Health. p. 25.
    Malhi, Gin S Morris, Grace Hamilton, Amber Outhred, Tim and Mannie, Zola 2017. Is “early intervention” in bipolar disorder what it claims to be?. Bipolar Disorders, Vol. 19, Issue. 8, p. 627.
    Mesman, E. Youngstrom, E.A. Juliana, N.K. Nolen, W.A. and Hillegers, M.H.J. 2017. Validation of the Seven Up Seven Down Inventory in bipolar offspring: screening and prediction of mood disorders. Findings from the Dutch Bipolar Offspring Study. Journal of Affective Disorders, Vol. 207, Issue. , p. 95.
    Duffy, A. Patten, S. Goodday, S. Weir, A. Heffer, N. and Cipriani, A. 2017. Efficacy and tolerability of lithium in treating acute mania in youth with bipolar disorder: protocol for a systematic review. International Journal of Bipolar Disorders, Vol. 5, Issue. 1,
    Papachristou, Efstathios Oldehinkel, Albertine J. Ormel, Johan Raven, Dennis Hartman, Catharina A. Frangou, Sophia and Reichenberg, Abraham 2017. The predictive value of childhood subthreshold manic symptoms for adolescent and adult psychiatric outcomes. Journal of Affective Disorders, Vol. 212, Issue. , p. 86.
    Pössel, Patrick and Meyer, Thomas D. 2017. Handbook of Social Behavior and Skills in Children. p. 363.
    Mesman, E. Nolen, W. A. Keijsers, L. and Hillegers, M. H. J. 2017. Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study. Acta Psychiatrica Scandinavica, Vol. 136, Issue. 2, p. 201.
    Pfennig, A. Ritter, P. S. Höfler, M. Lieb, R. Bauer, M. Wittchen, H.-U. and Beesdo-Baum, K. 2016. Symptom characteristics of depressive episodes prior to the onset of mania or hypomania. Acta Psychiatrica Scandinavica, Vol. 133, Issue. 3, p. 196.
    Fonseca-Pedrero, Eduardo Ortuño-Sierra, Javier Paino, Mercedes and Muñiz, José 2016. Detección del riesgo para los trastornos del espectro bipolar: evidencias de validez del Mood Disorder Questionnaire en adolescentes y adultos jóvenes. Revista de Psiquiatría y Salud Mental, Vol. 9, Issue. 1, p. 4.
    Klimes-Dougan, Bonnie Kennedy, Kevin P. and Cullen, Kathryn R. 2016. Developmental Psychopathology. p. 1.
    Fonseca-Pedrero, Eduardo Ortuño-Sierra, Javier Paino, Mercedes and Muñiz, José 2016. Screening the risk of bipolar spectrum disorders: Validity evidence of the Mood Disorder Questionnaire in adolescents and young adults. Revista de Psiquiatría y Salud Mental (English Edition), Vol. 9, Issue. 1, p. 4.
    Hunt, Jeffrey Schwarz, Charlotte M. Nye, Paul and Frazier, Elisabeth 2016. Is There a Bipolar Prodrome Among Children and Adolescents?. Current Psychiatry Reports, Vol. 18, Issue. 4,
    Download full list
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Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study

  • Marijn J. A. Tijssen (a1), Jim van Os (a2), Hans-Ulrich Wittchen (a3), Roselind Lieb (a4), Katja Beesdo (a5), Ron Mengelers (a1) and Marieke Wichers (a1)...
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