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A Preliminary Account of the Clinical Effects of Polarizing the Brain in Certain Psychiatric Disorders

  • J. W. T. Redfearn (a1), O. C. J. Lippold (a1) and R. Costain (a1)

Extract

A previous paper (Lippold and Redfearn, 1964) described the mental changes that can be produced by the passage of small polarizing currents through the brain in human subjects. It became apparent during the course of these experiments that some of the effects persisted for hours or days after the current had been turned off. A persistent excitatory after-effect of surface-positive cortical polarization has recently been demonstrated in the rat (Bindman, Lippold and Redfearn, 1962). It is possible that a similar phenomenon, at the cellular level, is responsible for the long-lasting psychological effects of polarization.

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Bindman, L. J., Lippold, O. C. J., and Redfearn, J. W. T. (1962). “Long-lasting changes in the level of the electrical activity of the cerebral cortex produced by polarizing currents.” Nature, 196, 584585.
Burns, B. D. (1957). “Electrophysiologic basis of normal and psychotic function”, in Psychotropic Drugs (ed. Garattini, S., and Ghetti, V.) Amsterdam: Elsevier. pp. 177184.
Lippold, O. C. J., and Redfearn, J. W. T. (1964). “Mental changes resulting from the passage of small direct currents through the human brain.” Brit. J. Psychiat., 110, 768772.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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A Preliminary Account of the Clinical Effects of Polarizing the Brain in Certain Psychiatric Disorders

  • J. W. T. Redfearn (a1), O. C. J. Lippold (a1) and R. Costain (a1)
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