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Mortality has been suggested to be increased in autism spectrum disorder (ASD).
To examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability.
Odds ratios (ORs) were calculated for a population-based cohort of ASD probands (n = 27 122, diagnosed between 1987 and 2009) compared with gender-, age- and county of residence-matched controls (n = 2 672 185).
During the observed period, 24 358 (0.91%) individuals in the general population died, whereas the corresponding figure for individuals with ASD was 706 (2.60%; OR = 2.56; 95% CI 2.38–2.76). Cause-specific analyses showed elevated mortality in ASD for almost all analysed diagnostic categories. Mortality and patterns for cause-specific mortality were partly moderated by gender and general intellectual ability.
Premature mortality was markedly increased in ASD owing to a multitude of medical conditions.
The study was funded by the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet (grants no. 20120419 and 20130630, Tatja Hirvikoski), Karolinska Institutet in cooperation with the Stockholm County Council (KI/SLL, 2008:9, Sven Bölte), the Swedish Research Council (grant no. 523-2009-7054, Sven Bölte) and the Swedish Research Council in cooperation with the Swedish Research Council for Health, Working Life and Welfare, Vinnova and FORMAS (cross-disciplinary research programme concerning children's and youth's mental health, grant no. 259-2012-24, Sven Bölte).
Declaration of interest
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