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Premature mortality in autism spectrum disorder

  • Tatja Hirvikoski (a1), Ellenor Mittendorfer-Rutz (a2), Marcus Boman (a3), Henrik Larsson (a3), Paul Lichtenstein (a3) and Sven Bölte (a4)...
Abstract
Background

Mortality has been suggested to be increased in autism spectrum disorder (ASD).

Aims

To examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability.

Method

Odds ratios (ORs) were calculated for a population-based cohort of ASD probands (n = 27 122, diagnosed between 1987 and 2009) compared with gender-, age- and county of residence-matched controls (n = 2 672 185).

Results

During the observed period, 24 358 (0.91%) individuals in the general population died, whereas the corresponding figure for individuals with ASD was 706 (2.60%; OR = 2.56; 95% CI 2.38–2.76). Cause-specific analyses showed elevated mortality in ASD for almost all analysed diagnostic categories. Mortality and patterns for cause-specific mortality were partly moderated by gender and general intellectual ability.

Conclusions

Premature mortality was markedly increased in ASD owing to a multitude of medical conditions.

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Copyright
Corresponding author
Tatja Hirvikoski, PhD/Neuropsychologist, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), CAP Research Center, Gävlegatan 22B, SE-11330 Stockholm, Sweden. Email: Tatja.Hirvikoski@ki.se
Footnotes
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Declaration of interest

None.

Footnotes
References
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  • EISSN: 1472-1465
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Premature mortality in autism spectrum disorder

  • Tatja Hirvikoski (a1), Ellenor Mittendorfer-Rutz (a2), Marcus Boman (a3), Henrik Larsson (a3), Paul Lichtenstein (a3) and Sven Bölte (a4)...
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