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Prepsychotic phase of schizophrenia and related disorders: recent progress and future opportunities

  • Lisa J. Phillips (a1), Patrick D. Mcgorry (a1), Alison R. Yung (a1), Thomas H. Mcglashan (a2), Barbara Cornblatt (a3) and Joachim Klosterkötter (a4)...

Abstract

Background

Clinical and research focus has recently shifted from established psychotic disorders to first-episode psychosis and the prepsychotic phase of illness.

Aims

To describe the principles, progress and dilemmas associated with the prospective detection, engagement and treatment of young people at risk of developing a psychotic disorder.

Method

Strategies to identify young people at heightened risk of a psychotic disorder are described. Preventive interventions and results of their evaluation are provided.

Results

Well-validated criteria for identifying young people at heightened risk of psychosis have been developed, evidence of the efficacy of various psychological and pharmacological interventions in preventing progression has accumulated and progress towards the identification of clinical and neurobiological predictors of transition to acute psychosis has been made.

Conclusions

The detection, monitoring and treatment of young people in the prepsychotic phase is a growth area in psychiatry. The ethical considerations about treatment options, treatment of minors and provision of information about risk status must be treated with sensitivity if the potential benefit to many young people and their families is to be realised.

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Copyright

Corresponding author

Lisa Phillips, PACE Clinic, Orygen Research Centre, Locked Bag 10, Parkville 8052, Victoria, Australia. E-mail: lisa.phillips@mh.org.au

Footnotes

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Paper presented at the Third International Early Psychosis Conference, Copenhagen, Denmark, September 2002.

Declaration of interest

None. Funding detailed in Acknowledgements.

Footnotes

References

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Prepsychotic phase of schizophrenia and related disorders: recent progress and future opportunities

  • Lisa J. Phillips (a1), Patrick D. Mcgorry (a1), Alison R. Yung (a1), Thomas H. Mcglashan (a2), Barbara Cornblatt (a3) and Joachim Klosterkötter (a4)...

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Prepsychotic phase of schizophrenia and related disorders: recent progress and future opportunities

  • Lisa J. Phillips (a1), Patrick D. Mcgorry (a1), Alison R. Yung (a1), Thomas H. Mcglashan (a2), Barbara Cornblatt (a3) and Joachim Klosterkötter (a4)...
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