Prevalence of autism-spectrum conditions: UK school-based
                            population study

Simon Baron-Cohen; Fiona J. Scott; Carrie Allison; Joanna Williams; Patrick Bolton; Fiona E. Matthews; Carol Brayne

doi:10.1192/bjp.bp.108.059345

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Volume 194, Issue 6
June 2009 , pp. 500-509

Prevalence of autism-spectrum conditions: UK school-based population study

Simon Baron-Cohen ^(a1), Fiona J. Scott ^(a1), Carrie Allison ^(a1), Joanna Williams ^(a2), Patrick Bolton ^(a1), Fiona E. Matthews ^(a3) and Carol Brayne ^(a4)...

- DOI: https://doi.org/10.1192/bjp.bp.108.059345
- Published online by Cambridge University Press: 02 January 2018

Abstract

Background

Recent reports estimate the prevalence of autism-spectrum conditions in the UK to be 1%.

Aims

To use different methods to estimate the prevalence of autism-spectrum conditions, including previously undiagnosed cases, in Cambridgeshire.

Method

We carried out a survey of autism-spectrum conditions using the Special Educational Needs (SEN) register. A diagnosis survey was distributed to participating schools to be handed out to parents of all children aged 5–9 years. The mainstream primary school population was screened for unknown cases.

Results

The prevalence estimates generated from the SEN register and diagnosis survey were 94 per 10 000 and 99 per 10 000 respectively. A total of 11 children received a research diagnosis of an autism-spectrum condition following screening and assessment. The ratio of known:unknown cases is about 3:2 (following statistical weighting procedures). Taken together, we estimate the prevalence to be 157 per 10 000, including previously undiagnosed cases.

Conclusions

This study has implications for planning diagnostic, social and health services.

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Copyright

COPYRIGHT: © Royal College of Psychiatrists, 2009

Corresponding author

Simon Baron–Cohen, University of Cambridge, Autism Research Centre, Department of Psychiatry, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK. Email: sb205@cam.ac.uk

Footnotes

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∗

These authors contributed equally to the work.

This study was funded by the Shirley Foundation. S.B-C., F.J.M. and J.W. were funded by the Medical Research Council during the period of this work. P.B. was supported by the UK NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, King's College London, and the South London and Maudsley NHS Foundation Trust.

Declaration of interest

F.J.S acted as an expert witness for the diagnosis of autism-spectrum conditions and for the measles, mumps and rubella vaccine litigation, but not for children in the population covered by this study.

Footnotes

∗

These authors contributed equally to the work.

This study was funded by the Shirley Foundation. S.B-C., F.J.M. and J.W. were funded by the Medical Research Council during the period of this work. P.B. was supported by the UK NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, King's College London, and the South London and Maudsley NHS Foundation Trust.

Declaration of interest

F.J.S acted as an expert witness for the diagnosis of autism-spectrum conditions and for the measles, mumps and rubella vaccine litigation, but not for children in the population covered by this study.

References

Hide All

1 World Health Organization. The ICD–10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. WHO, 1993.

2 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). APA, 1994.

3 Baron-Cohen, S, Hoekstra, RA, Knickmeyer, R, Wheelwright, S. The Autism-Spectrum Quotient (AQ) – adolescent version. J Autism Dev Disord 2006; 36: 343–50.

4 Baron-Cohen, S, Wheelwright, S, Skinner, R, Martin, J, Clubley, E. The Autism-Spectrum Quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 2001; 31: 5–17.

5 Wakabayashi, A, Baron-Cohen, S, Wheelwright, S, Tojo, Y. The Autism-Spectrum Quotient (AQ) in Japan: a cross-cultural comparison. J Autism Dev Disord 2006; 36: 263–70.

6 Wakabayashi, A, Baron-Cohen, S, Uchiyama, T, Yoshida, Y, Tojo, Y, Kuroda, M, et al. The Autism-Spectrum Quotient (AQ) children's version in Japan: a cross-cultural comparison. J Autism Dev Disord 2007; 37: 491–500.

7 Constantino, JN, Todd, RD. Autistic traits in the general population: a twin study. Arch Gen Psychiatry 2003; 60: 524–30.

8 Scott, FJ, Baron-Cohen, S, Bolton, P, Brayne, C. The CAST (Childhood Asperger Syndrome Test): preliminary development of a UK screen for mainstream primary-school-age children. Autism 2002; 6: 9–31.

9 Rutter, M. Diagnosis and definition of childhood autism. J Autism Child Schizophr 1978; 8: 139–61.

10 Baird, G, Simonoff, E, Pickles, A, Chandler, S, Loucas, T, Meldrum, D, et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 2006; 368: 210–5.

11 Charman, T. The prevalence of autism spectrum disorders. Recent evidence and future challenges. Eur Child Adolesc Psychiatry 2002; 11: 249–56.

12 Williams, JG, Higgins, JP, Brayne, CE. Systematic review of prevalence studies of autism spectrum disorders. Arch Dis Child 2006; 91: 8–15.

13 Fombonne, E. Epidemiological trends in rates of autism. Mol Psychiatry 2002; 7 (suppl 2): s4–6.

14 Fombonne, E. The prevalence of autism. JAMA 2003; 289: 87–9.

15 Fombonne, E. Epidemiological surveys of autism and other pervasive developmental disorders: an update. J Autism Dev Disord 2003; 33: 365–82.

16 Wing, L, Potter, D. The epidemiology of autistic spectrum disorders: is the prevalence rising? Ment Retard Dev Disabil Res Rev 2002; 8: 151–61.

17 Bertrand, J, Mars, A, Boyle, C, Bove, F, Yeargin-Allsopp, M, Decoufle, P. Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. Pediatrics 2001; 108: 1155–61.

18 Croen, LA, Grether, JK, Hoogstrate, J, Selvin, S. The changing prevalence of autism in California. J Autism Dev Disord 2002; 32: 207–15.

19 Yeargin-Allsopp, M, Rice, C, Karapurkar, T, Doernberg, N, Boyle, C, Murphy, C. Prevalence of autism in a US metropolitan area. JAMA 2003; 289: 49–55.

20 Mattila, ML, Kielinen, M, Jussila, K, Linna, SL, Bloigu, R, Ebeling, H, et al. An epidemiological and diagnostic study of asperger syndrome according to four sets of diagnostic criteria. J Am Acad Child Adolesc Psychiatry 2007; 46: 636–46.

21 Ehlers, S, Gillberg, C, Wing, L. A screening questionnaire for Asperger syndrome and other high-functioning autism spectrum disorders in school age children. J Autism Dev Disord 1999; 29: 129–41.

22 Williams, J, Scott, F, Stott, C, Allison, C, Bolton, P, Baron-Cohen, S, et al. The CAST (Childhood Asperger Syndrome Test): test accuracy. Autism 2005; 9: 45–68.

23 Office for National Statistics. The National Statistics Socio-economic Classification (NS-SEC). ONS, 2002 (http://www.statistics.gov.uk/nsbase/methods_quality/ns_sec/default.asp).

24 Lord, C, Risi, S, Lambrecht, L, Cook, EH Jr, Leventhal, BL, DiLavore, PC, et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 2000; 30: 205–23.

25 Lord, C, Rutter, M, Le Couteur, A. Autism Diagnostic Interview – Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994; 24: 659–85.

26 Williams, J, Allison, C, Scott, F, Stott, C, Bolton, P, Baron-Cohen, S, et al. The Childhood Asperger Syndrome Test (CAST): test–retest reliability. Autism 2006; 10: 415–27.

27 Allison, C, Williams, J, Scott, F, Stott, C, Bolton, P, Baron-Cohen, S, et al. The Childhood Asperger Syndrome Test (CAST): test–retest reliability in a high scoring sample. Autism 2007; 11: 173–85.

28 Ronald, A, Happe, F, Bolton, P, Butcher, LM, Price, TS, Wheelwright, S, et al. Genetic heterogeneity between the three components of the autism spectrum: a twin study. J Am Acad Child Adolesc Psychiatry 2006; 45: 691–9.

29 Bishop, DV, Norbury, CF. Exploring the borderlands of autistic disorder and specific language impairment: a study using standardised diagnostic instruments. J Child Psychol Psychiatry 2002; 43: 917–29.

30 NOMIS – Official Labour Market Statistics. Census 2001. Office for National Statistics, 2001 (https://www.nomisweb.co.uk/default.asp).

31 Efron, B. Bootstrap methods: another look at the jackknife. Ann Stat 1979; 7: 1–26.

32 Rutter, M. Aetiology of autism: findings and questions. J Intellect Disabil Res 2005; 49: 231–8.

33 Fombonne, E. The changing epidemiology of autism. J Applied Res Intell Dis 2005; 18: 281–94.

34 Gillberg, C, Cederlund, M, Lamberg, K, Zeijlon, L. Brief report: ‘the autism epidemic’. The registered prevalence of autism in a Swedish urban area. J Autism Dev Disord 2006; 36: 429–35.

35 Kadesjo, B, Gillberg, C, Hagberg, B. Brief report: autism and Asperger syndrome in seven-year-old children: a total population study. J Autism Dev Disord 1999; 29: 327–31.

36 Rose, G, Barker, DJ. Conduct of surveys. BMJ 1978; 2: 1201–2.

37 Posserud, MB, Lundervold, AJ, Gillberg, C. Autistic features in a total population of 7–9-year-old children assessed by the ASSQ (Autism Spectrum Screening Questionnaire). J Child Psychol Psychiatry 2006; 47: 167–75.

38 Department for Children, Schools and Families. Education and training statistics for the United Kingdom 2007. National Statistics, 2007 (http://www.dcsf.gov.uk/rsgateway/DB/VOL/v000761/index.shtml).

39 Ehlers, S, Gillberg, C. The epidemiology of Asperger syndrome. A total population study. J Child Psychol Psychiatry 1993; 34: 1327–50.

40 Wing, L. Sex ratios in early childhood autism and related conditions. Psychiatry Res 1981; 5: 129–37.

41 Lutchmaya, S, Baron-Cohen, S, Raggatt, P. Foetal testosterone and eye contact in 12-month-old human infants. Infant Behav Dev 2002; 25: 327–35.

42 Lutchmaya, S, Baron-Cohen, S, Raggatt, P. Foetal testosterone and vocabulary size in 18- and 24-month-old infants. Infant Behav Dev 2002; 24: 418–24.

43 Williams, JG, Allison, C, Scott, FJ, Bolton, PF, Baron-Cohen, S, Matthews, FE, et al. The Childhood Autism Spectrum Test (CAST): sex differences. J Autism Dev Disord 2008; 38: 1731–9.

44 Holliday-Willey, L. Pretending to be Normal. Living with Asperger's Syndrome. Jessica Kingsley Publishers, 1999.

45 Kopp, S, Gillberg, C. Girls with social deficits and learning problems: autism, atypical Asperger syndrome or a variant of these conditions. Eur Child Adolesc Psychiatry 1992; 1: 89–99.

46 Wolff, S, McGuire, RJ. Schizoid personality in girls: a follow-up study – what are the links with Asperger's syndrome? J Child Psychol Psychiatry 1995; 36: 793–817.

47 Allison, C, Baron-Cohen, S, Wheelwright, S, Charman, T, Richler, J, Pasco, G, et al. The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): a normally distributed quantitative measure of autistic traits at 18–24 months of age: preliminary report. J Autism Dev Disord 2008; 38: 1414–25.