Skip to main content
×
×
Home

Prevention of first-episode depression: progress and potential

  • Robert G. Robinson (a1) and Ricardo E. Jorge (a1)
Summary

Preventive intervention for first-episode depression is an exciting, emerging field. Many questions remain, however. Should we target patients who have sub-syndromal symptom elevations (i.e. indicated intervention) or should we intervene in high-risk groups (i.e. selective intervention)? Furthermore, should primary outcomes be incident depressions or long-term decreases in morbidity or mortality?

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Prevention of first-episode depression: progress and potential
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Prevention of first-episode depression: progress and potential
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Prevention of first-episode depression: progress and potential
      Available formats
      ×
Copyright
Corresponding author
Correspondence: Robert G. Robinson, Department of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. Email: robert-robinson@uiowa.edu
Footnotes
Hide All

Declaration of interest

None.

Footnotes
References
Hide All
1 Committee on Prevention of Mental Disorders, Institute of Medicine. Reducing Risks for Mental Disorders: Frontiers for Preventive Intervention Research. National Academy Press, 1994.
2 Keller, MB, Trivedi, MH, Thase, ME, Shelton, RC, Kornstein, SG, Nemeroff, CB, et al. The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases. Biol Psychiatry 2007; 62: 1371–9.
3 Frank, E, Kupfer, DJ, Buysse, DJ, Swartz, HA, Pilkonis, PA, Houck, PR, et al. Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression. Am J Psychiatry 2007; 164: 761–7.
4 Rovner, BW, Casten, RJ, Hegel, MT, Leiby, BE, Tasman, WS. Preventing depression in age-related macular degeneration. Arch Gen Psychiatry 2007; 64: 886–92.
5 Robinson, RG, Jorge, RE, Moser, DJ, Acion, L, Solodkin, A, Small, SL, et al. Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA 2008; 299: 2391–400.
6 Rasmussen, A, Lunde, M, Poulsen, DL, Sorensen, K, Qvitzau, S, Bech, P. A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics 2003; 44: 216–21.
7 Reynolds, CF 3rd, Dew, MA, Lenze, EJ, Whyte, EM. Preventing depression in medical illness: a new lead? Arch Gen Psychiatry 2007; 64: 884–5.
8 Smit, F, Ederveen, A, Cuijpers, P, Deeg, D, Beekman, A. Opportunities for cost-effective prevention of late-life depression: an epidemiological approach. Arch Gen Psychiatry 2006; 63: 290–6.
9 Robinson, RG. The Clinical Neuropsychiatry of Stroke (2nd edn). Cambridge University Press, 2006.
10 Frasure-Smith, N, Lesperance, F, Talajic, M. Depression following myocardial infarction. Impact on 6-month survival. JAMA 1993; 270: 1819–25.
11 Jorge, RE, Robinson, RG, Arndt, S, Starkstein, SE. Mortality and post-stroke depression: a placebo controlled trial of antidepressants. Am J Psychiatry 2003; 160: 1823–9.
12 Glassman, AH, Bigger, JT Jr. Antidepressants in coronary heart disease: SSRIs reduce depression, but do they save lives? JAMA 2007; 297: 411–2.
13 Reynolds, TM, Mardani, A, Twomey, PJ, Wierzbickid, AS. Targeted versus global approaches to the management of hypercholesterolaemia. J R Soc Health 2008; 128: 248–54.
14 Salaycik, KJ, Kelly-Hayes, M, Beiser, A, Nguyen, AH, Brady, SM, Kase, CS, et al. Depressive symptoms and risk of stroke: the Framingham Study. Stroke 2007; 38: 1621.
15 Schubert, DS, Taylor, C, Lee, S, Mentari, A, Tamaklo, W. Detection of depression in the stroke patient. Psychosomatics 1992; 33: 290–4.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 14 *
Loading metrics...

Abstract views

Total abstract views: 54 *
Loading metrics...

* Views captured on Cambridge Core between 2nd January 2018 - 20th May 2018. This data will be updated every 24 hours.

Prevention of first-episode depression: progress and potential

  • Robert G. Robinson (a1) and Ricardo E. Jorge (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *