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Psychiatric Phenomena in Alzheimer's Disease. IV: Disorders of Behaviour

  • Alastair Burns, Robin Jacoby and Raymond Levy (a1)
Abstract

Out of a sample of 178 patients with AD, aggression was present in 20%, wandering in 19%, binge-eating in 10%, hyperorality in 6%, urinary incontinence in 48%, and sexual disinhibition in 7%. Behavioural abnormalities were greater in those with more severe dementia. Temporal-lobe atrophy correlated with aggression, and widening of the third ventricle with hyperorality. Features of the Kluver–Bucy syndrome were commonly seen, but the full syndrome occurred in only one subject. Patients with at least one feature of the Kluver–Bucy syndrome had greater temporal-lobe atropy than those without any of the features.

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Abas, M., Sahakian, B. & Levy, R. (1990) Neuropsychological deficits and CT scan changes in elderly depressives. Psychological Medicine (in press).
Adolfsson, R., Gottfries, C., Roos, B., et al (1979) Changes in the brain catecholamines in patients with dementia of Alzheimer type. British Journal of Psychiatry, 135, 216223.
Alzheimer, A. (1907) Über eine Eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift für Psychiatrie und Psychisch–Gerichtlich Median, 64, 146148.
American Psychiatric Association (1967) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.
Berrios, G. & Brook, P. (1984) Visual hallucinations and sensory delusions in the elderly. British Journal of Psychiatry, 144, 662664.
Berrios, G. & Brook, P. (1985) Delusions and the psychopathology of the elderly with dementia. Acta Psychiatrica Scandinavica, 72, 296301.
Birkett, D. (1972) The psychiatric differentiation of senility and arteriosclerosis. British Journal of Psychiatry; 120, 321325.
Branchey, L., Branchey, M., Shaw, S., et al (1984) Depression, suicide and aggression in alcoholics and their relationship to plasma amino acids. Psychiatric Research, 12, 219226.
Bucht, G. & Adolfsson, R. (1983) The comprehensive psychopathological rating scale in patients with dementia of the Alzheimer type and multi-infarct dementia. Acta Psychiatric Scandinavica, 68, 263270.
Burke, W., Rubin, E., Morris, J., et al (1988) Symptoms of ‘depression’ in dementia of the Alzheimer type. Alzheimer's Disease and Associated Disorders, 2, 43564362.
Burns, A. & Philpot, M. (1987) Capgras' syndrome in a patient with dementia. British Journal of Psychiatry, 150, 876877.
Burns, A., Carrick, J., Ames, D., et al (1989) The cerebral cortical appearance in late paraphrenia. International Journal of Geriatric Psychiatry, 4, 3134.
Copeland, J., Kelleher, M., Kellett, J., et al (1976) The Geriatric Mental State Schedule: 1 Development and reliability. Psychological Medicine, 6, 439449.
Cummings, J. (1985) Organic delusions: phenomenology, anatomical correlations and review. British Journal of Psychiatry, 146, 184197.
Cummings, J. & Duchen, L. (1981) Kluver–Bucy syndrome in Pick disease: clinical and pathologic conditions. Neurology, 31, 14151422.
Cummings, J. & Benson, D. (1983) Dementia: A Clinical Approach. Boston: Butterworths.
Cummings, J., Miller, B., Hill, M. A., et al (1987) Neuropsychiatric Aspects of multi-infarct dementia and dementia of the Alzheimer type. Archives of Neurology, 44, 389393.
Cummings, J., Gosenfeld, L., Houlihan, J., et al (1983) Neuropsychiatric disturbances associated with idiopathic calcification of the basal ganglia. Biological Psychiatry, 18, 591601.
Cutting, J. (1987) The phenomenology of acute organic psychosis: comparison with acute schizophrenia. British Journal of Psychiatry, 151, 324332.
Dewhurst, K., Oliver, J., Trick, K., et al (1969) Neuropsychiatric aspects of Huntington's disease. Confinia Neurologica, 31, 258268.
Dolan, R., Calloway, S., Thacker, P., et al (1986) Cerebral cortical appearance in depressed subjects. Psychological Medicine, 16, 775779.
Drevets, W. & Rubin, E. (1989) Psychotic symptoms in the longitudinal course of senile dementia of the Alzheimer type. Biological Psychiatry, 25, 3948.
Fairburn, C. & Hope, R. (1988a) Changes in behaviour in dementia: a neglected research area. British Journal of Psychiatry, 152, 406407.
Fairburn, C. & Hope, R. (1988b) Changes in eating in dementia. Neurobiology of Ageing, 9, 2829.
Fair weather, D. (1947) Psychiatric aspects of the post-encephalitic syndrome. Journal of Mental Science, 93, 201254.
Fish, F. (1985) Fish's Clinical Psychopathology (2nd edn) (ed. M. Hamilton). Bristol: Wright.
Folstein, M., Folstein, S. & McHugh, P. (1975) Mini-Mental State. Journal of Psychiatric Research, 12, 189198.
Frances, A. (1979) Familial basal ganglia calcification and schizophreniform psychosis. British Journal of Psychiatry, 135, 360362.
Goodman, L. (1953) Alzheimer's disease: a clinical and pathologic analysis of 23 cases with a theory on pathogenesis. Journal of Nervous and Mental Disease, 117, 97130.
Green, J., Clement, C. & De Groot, J. (1957) Rhinencephalic lesions and behaviour in cats. Journal of Comparative Neurology, 108, 505536.
Gustafson, L. & Risberg, J. (1974) Regional cerebral blood flow related to psychiatric symptoms in dementia with onset in the pre-senile period. Acta Psychiatrica Scandinavica, 50, 516538.
Heath, R. & Mickle, W. (1960) Evaluation of seven years' experience with depth electrode studies in human patients. In Electrical studies of the Unanaesthetised Brain (eds E. Ramey & D. O'Docherty), pp. 214247. New York: Hober.
Hendrickson, E., Levy, R. & Post, F. (1979) Averaged evoked responses in relation to cognitive and affective state of elderly psychiatric patients. British Journal of Psychiatry, 134, 494501.
Hitchcock, E. & Cairns, V. (1973) Amygdalotomy. Postgraduate Medical Journal, 49, 894904.
Hope, R., Fairburn, C. & Goodwin, G. (1989) Increased eating in dementia. International Journal of Eating Disorders, 8, 111115.
Hughes, C., Berg, L., Danziger, W., et al (1982) A new clinical skill for the staging of dementia. British Journal of Psychiatry, 140, 566572 (updated by Berg, L. (1984)). British Journal of Psychiatry, 145, 339.
Jacoby, R. & Levy, R. (1980) Computed tomography in the elderly: 2. Senile dementia: diagnosis and functional impairment. British Journal of Psychiatry, 136, 256269.
Kay, D. W. K. (1962) Outcome and cause of death in mental disorders of old age: a long term follow up of functional and organic psychoses. Acta Psychiatrica Scandinavica, 38, 249276.
Kiloh, L. (1961) Pseudo-dementia. Acta Psychiatrica Scandinavica, 37, 336351.
Kluver, H. & Bucy, P. (1937) “Psychic blindness” and other symptoms following bilateral temporal lobectomy in rhesus monkeys. American Journal of Physiology, 119, 352.
Knesevich, J., Martin, R., Berg, L., et al (1983) Preliminary report on affective symptoms in the early stages of senile dementia of the Alzheimer type. American Journal of Psychiatry, 140, 233235.
Kral, V. (1983) The relationship between senile dementia (Alzheimer type) and depression. Canadian Journal of Psychiatry, 28, 304306.
Kumar, A., Koss, E., Metzler, D., et al (1988) Behavioural symptomatology in dementia of the Alzheimer type. Alzheimer's Disease and Associated Disorders, 2, 363365.
Lazarus, L., Newton, N., Cohler, B., et al (1987) Frequency in presentation of depressive symptoms in patients with primary degenerate dementia. American Journal of Psychiatry, 144, 4145.
Lemoine, P., Flachaire, E., Beney, C., et al (1984) Study of the platelet serotonin concentrations in the whole population of a psychiatric unit. New Research Strategies in Biological Psychiatry (ed. Kamali). London: Libby.
Leuchter, A. & Spar, J. (1985) The late onset psychoses: clinical and diagnostic features. Journal of Nervous and Mental Disease, 173, 488494.
Lishman, W. A. (1987) Organic Psychiatry (2nd edn). Oxford: Blackwell Scientific.
Martin, E., Wilson, R., Penn, R., et al (1987) Cortical biopsy results in Alzheimer's disease: correlation with cognitive deficits. Neurology, 37, 12011204.
Mayer-Gross, W., Slater, E. & Roth, M. (1960) Clinical Psychiatry. London: Cassell.
Mayeux, R., Stern, Y. & Sano, N. (1985) Psychosis in patients with dementia of the Alzheimer type. Annals of Neurology, 18, 144.
McDonald, C. (1969) Clinical heterogeneity in senile dementia. British Journal of Psychiatry, 115, 267271.
McKhann, G., Drachman, D., Folstein, M., et al (1984) Clinical diagnosis of Alzheimer's disease: report on the NINCDS-ADRDA work group under the auspices of the Dept. of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939944.
Meer, B. & Baker, J. (1966) Stockton Geriatric Rating Scale. Journal of Gerontology, 21, 392403.
Merriam, A., Aronson, N., Gaston, P., et al (1988) The psychiatric symptoms of Alzheimer's disease. Journal of the American Geriatric Society, 36, 712.
Morris, C., Hope, R. & Fairburn, C. (1989) Eating habits in dementia: a descriptive study. British Journal of Psychiatry, 154, 801806.
Mover, K. (1971) The Physiology of Hostility. Chicago: Markham.
Murphy, M. (1979) Clinical correlations of CT scan – detected calcifications of the basal ganglia. Annals of Neurology, 6, 507511.
Naguib, M. & Levy, R. (1982) Prediction of outcome in senile dementia – a computed tomography study. British Journal of Psychiatry, 140, 263267.
Pearlson, G., Rabins, P., Kim, W., et al (1989) Structural brain CT and cognitive deficits in elderly depressives with and without reversible dementia. Psychological Medicine, 19, 573584.
Pilleri, G. (1966) The Kluver–Bucy syndrome in man. Psychiatric Neurology (Basel), 152, 65103.
Post, F. (1962) The Significance of Affective Symptoms in Old Age. London: Oxford University Press.
Rabins, P., Mace, M. & Lucas, M. (1982) The impact of dementia on the family. Journal of the American Medical Association, 248, 333335.
Rabins, P., Merchant, A. & Nestadt, G. (1984) Criteria for diagnosing reversible dementia caused by depression. British Journal of Psychiatry, 144, 488492.
Reding, M., Haycox, J. & Blass, J. (1985) Depression in patients referred to a dementia clinic. Archives of Neurology, 42, 894896.
Reifler, B., Larson, E. & Harley, R. (1982) Co-existence of cognitive impairment and depression in geriatric outpatients. American Journal of Psychiatry, 139, 623626.
Reisberg, B., Borenstein, J., Salob, S., et al (1987) Behavioural symptoms in Alzheimer's disease: phenomenology and treatment. Journal of Clinical Psychiatry, 48, (suppl. 5), 915.
Rennick, P., Nolan, D., Baver, R., et al (1973) Neuropsychological and neurological follow up after herpes hominis encephalitis. Neurology, 23, 4247.
Rossor, M., Iverson, L., Reynolds, G., et al (1984) Neurochemical characteristics of early and late onset types of Alzheimer's disease. British Medical Journal, 288, 961964.
Roth, M., Tym, E., Mountjoy, C., et al (1986) CAMDEX: a standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 149, 698709.
Rothschild, A. (1941) The clinical differentiation of senile and arteriosclerotic psychoses. American Journal of Psychiatry, 98, 324333.
Rubin, E., Drevets, W. & Burke, A. (1988) The nature of psychotic symptoms in senile dementia of the Alzheimer type. Journal of Geriatric Psychiatry and Neurology, 1, 1620.
Ryden, M. (1988) Aggressive behaviour in persons with dementia who live in the community. Alzheimer Disease and Associated Disorders, 2, 342355.
Sanford, J. (1975) Tolerance of disability in elderly dependents by supporters at home: its significance for hospital practice. British Medical Journal, iii, 471473.
Seltzer, B. & Sherwin, I. (1983) A comparison of clinical features in early and late onset primary degenerative dementia. Archives of Neurology, 40, 143146.
Shulman, K. & Post, F. (1980) Bipolar affective disorder in old age. British Journal of Psychiatry, 136, 2632.
Sim, M. & Sussman, I. (1962) Alzheimer's disease: its natural history and differential diagnosis. Journal of Nervous and Mental Disease, 135, 489499.
Sjogren, P., Sjogren, H. & Lindgren, A. G. H. (1952) Morbus Alzheimer and morbus Pick. Acta Psychiatrica and Neurologica Scandinavica (suppl. 82).
Smith, D., King, M. & Hoebelb, G. (1970) Lateral hypothalamic controls of killing: evidence for a cholinergic mechanism. Science, 167, 900901.
Sourander, P. & Sjogren, H. (1970) The concept of Alzheimer's disease and its clinical implications. In Alzheimer's Disease and Related Conditions (eds G. Wolstenholme & M. O'Connor), pp. 1132. London: Churchill.
Stern, Y., Mayeux, R., Sano, M., et al (1987) Predictors of disease course in patients with Alzheimer's disease. Neurology, 37, 16491653.
Swearer, J., Drachman, D., O'Donnell, B., et al (1988) Troublesome and destructive behaviours in dementia. Journal of the American Geriatric Society, 36, 784790.
Swigar, M., Benes, F., Rothman, S., et al (1985) Behavioural correlates of CT scan changes in older psychiatric patients. Journal of the American Geriatric Society, 33, 96103.
Teri, L., Larson, E. B. & Reifler, B. (1988) Behavioural disturbance in dementia of the Alzheimer type. Journal of the American Geriatric Society, 37, 109116.
Teri, L., Borson, S., Kiyak, A., et al (1989) Behavioural disturbance, cognitive dysfunction and functional skill: prevalence and relationship in Alzheimer's disease. Journal of the American Geriatrics Society, 37, 109116.
Terzain, H. & Ore, G. (1955) Syndrome of Kluver and Bucy. Neurology, 5, 373380.
Thompson, P. & Blessed, G. (1967) Correlation between the 37-item mental test score and abbreviated ten-item mental test score by psychogeriatric day patients. British Journal of Psychiatry, 151, 206209.
Tierney, M., Fisher, R., Lewis, A., et al (1988) The NINCDS–ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology, 38, 359364.
Toone, B. (1981) Psychoses in epilepsy. In Epilepsy in Psychiatry (eds E. Reynolds & M. Trimble). New York: Churchill Livingstone.
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.
Wraog, R. & Jeste, D. (1989) Overview of depression and psychosis in Alzheimer's disease. American Journal of Psychiatry, 146, 577587.
World Health Organization (1989) International Classification of Diseases (draft of 10th edn) (ICD–10). Geneva: WHO.
Ziegler, D. (1954) Cerebral atrophy in psychiatric patients. American Journal of Psychiatry, 111, 5458.
Zubenko, G. & Moossy, J. (1988) Major depression in primary dementia – clinical and neuropathologic correlates. Archives of Neurology, 45, 11821186.
Zweig, R., Ross, C., Hedreen, J., et al (1988) The neuropathology of aminergic nuclei in Alzheimer's disease. Annals of Neurology, 24, 233242.
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Psychiatric Phenomena in Alzheimer's Disease. IV: Disorders of Behaviour

  • Alastair Burns, Robin Jacoby and Raymond Levy (a1)
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