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The British Journal of Psychiatry The British Journal of Psychiatry

Article contents

Relationship between antisocial behaviour, attention-deficit hyperactivity disorder and maternal prenatal smoking

Published online by Cambridge University Press:  02 January 2018

T. M. M. Button ,
A. Thapar  and
P. McGuffin
T. M. M. Button*
Affiliation:
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Denmark Hill, London SE5 8AF
A. Thapar
Affiliation:
Section of Child and Adolescent Psychiatry, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
P. McGuffin
Affiliation:
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Denmark Hill, London
*
Dr T. M. M. Button, Institute for Behavioral Genetics, 447 UCB, Boulder, CO80309-447, USA. E-mail: tanya.button@colorado.edu
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Abstract

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Background

There is substantial evidence that maternal smoking during pregnancy is associated with both antisocial behaviour and symptoms of attention-deficit hyperactivity disorder (ADHD) in offspring. However, it is not clear whether maternal smoking during pregnancy is independently associated with antisocial behaviour or whether the association arises because antisocial behaviour and ADHD covary.

Aims

To examine the relationship between maternal smoking during pregnancy, antisocial behaviour and ADHD in offspring.

Method

Questionnaires concerning behaviour and environmental factors were sent to twins from the CaStANET study and data analysed using a number of bivariate structural equation models.

Results

Maternal prenatal smoking contributed small but significant amounts to the variance of ADHD and of antisocial behaviour. The best fitting bivariate model was one in which maternal prenatal smoking had a specific influence on each phenotype, independent of the effect on the other phenotype.

Conclusions

Both antisocial behaviour and ADHD symptoms in offspring are independently influenced by maternal prenatal smoking during pregnancy.

Type
Papers
Information
The British Journal of Psychiatry , Volume 187 , Issue 2 , August 2005 , pp. 155 - 160
Copyright
Copyright © 2005 The Royal College of Psychiatrists 

Footnotes

Declaration of interest

None. Funding detailed in Acknowledgement.

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