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Relationships Among Negative, Positive, and Depressive Symptoms in Schizophrenia and Psychotic Depression

  • Kenji W. Sax (a1), Stephen M. Strakowski (a1), Paul E. Keck (a1), Vidya H. Upadhyaya (a1), Scott A. West (a2) and Susan L. McElroy (a1)...
Abstract
Background

We examined relationships among positive, negative, and depressive symptoms in schizophrenia and major depression with psychosis.

Method

Patients with schizophrenia (n = 17) and major depression and psychotic features (n = 25), with no prior psychopharmacologic treatment were assessed on scales measuring positive psychotic, negative, and depressive symptoms.

Results

Analyses revealed that depressive symptoms positively correlated with anhedonia/asociality and avolition/apathy in both patient groups. Positive psychotic symptoms significantly correlated with depressive symptoms in the schizophrenic group.

Conclusions

Several specific symptoms used in defining both depressive and negative syndrome constructs appear to be shared. The relationship between positive symptoms and depression in schizophrenia and not psychotic depression suggests the severity of depression may be involved in this relationship.

Copyright
Corresponding author
Dr Sax, Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Bethesda Avenue (ML 559), Cincinnati, Ohio, 45267-0559, USA. Fax: (513)558-2882
References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Relationships Among Negative, Positive, and Depressive Symptoms in Schizophrenia and Psychotic Depression

  • Kenji W. Sax (a1), Stephen M. Strakowski (a1), Paul E. Keck (a1), Vidya H. Upadhyaya (a1), Scott A. West (a2) and Susan L. McElroy (a1)...
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