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Repetitive transcranial magnetic stimulation in non-treatment-resistant depression

  • Maximilian Kiebs (a1), René Hurlemann (a2) and Julian Mutz (a3)

Summary

Repetitive transcranial magnetic stimulation (rTMS) has been investigated as treatment for major depressive episodes since the early 1990s. Using data from a recent meta-analysis, we show that most patients included in randomised trials display relatively high degrees of treatment resistance. This might have unfavourably biased the clinical reputation of rTMS.

Declaration of interests

M.K. has received a lecture fee from Innomed Medizintechnik in 2017 and 2018.

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Copyright

Corresponding author

Correspondence: Julian Mutz, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Memory Lane, Camberwell, London SE5 8AF, UK. Email: julian.mutz@gmail.com.

References

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1Mutz, J, Vipulananthan, V, Carter, B, Hurlemann, R, Fu, CHY, Young, AH. Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis. BMJ 2019; 364: l1079.
2Mutz, J, Edgcumbe, DR, Brunoni, AR, Fu, CHY. Efficacy and acceptability of non-invasive brain stimulation for the treatment of adult unipolar and bipolar depression: a systematic review and meta-analysis of randomised sham-controlled trials. Neurosci Biobehav Rev 2018; 92: 291303.
3Lisanby, SH, Husain, MM, Rosenquist, PB, Maixner, D, Gutierrez, R, Krystal, A, et al. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology 2009; 34: 522–34.
4Blumberger, DM, Vila-Rodriguez, F, Thorpe, KE, Feffer, K, Noda, Y, Giacobbe, P, et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial. Lancet 2018; 391: 1683–92.
5Voigt, J, Carpenter, L, Leuchter, A. Cost effectiveness analysis comparing repetitive transcranial magnetic stimulation to antidepressant medications after a first treatment failure for major depressive disorder in newly diagnosed patients – A lifetime analysis. PLoS ONE 2017; 12: e0186950.

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Repetitive transcranial magnetic stimulation in non-treatment-resistant depression

  • Maximilian Kiebs (a1), René Hurlemann (a2) and Julian Mutz (a3)

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Repetitive transcranial magnetic stimulation in non-treatment-resistant depression

  • Maximilian Kiebs (a1), René Hurlemann (a2) and Julian Mutz (a3)
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