1
Burmeister, M, McInnis, MG, Zöllner, S. Psychiatric genetics: progress amid controversy. Nat Rev Genet
2008; 9: 527–40.
2
O'Donovan, MC, Craddock, NJ, Owen, MJ. Genetics of psychosis; insights from views across the genome. Hum Genet
2009; 126: 3–12.
3
Zhou, X, Qyang, Y, Kelsoe, JR, Masliah, E, Geyer, MA. Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice. Genes Brain Behav
2007; 6: 269–76.
4
Ramos, B, Gaudillière, B, Bonni, A, Gill, G. Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Proc Natl Acad Sci U S A
2007; 104: 9882–7.
5
Shi, J, Potash, JB, Knowles, JA, Weissman, MM, Coryell, W, Scheftner, WA, et al. Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry
2011; 16: 193–201.
6
Shyn, SI, Shi, J, Kraft, JB, Potash, JB, Knowles, JA, Weissman, MM, et al. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry
2011; 16: 202–15.
7
Zhou, X, Tang, W, Greenwood, TA, Guo, S, He, L, Geyer, MA, et al. Transcription factor SP4 is a susceptibility gene for bipolar disorder. PLoS One
2009; 4: e5196.
8
Tam, GW, van de Lagemaat, LN, Redon, R, Strathdee, KE, Croning, MD, Malloy, MP, et al. Confirmed rare copy number variants implicate novel genes in schizophrenia. Biochem Soc Trans
2010; 38: 445–51.
9
Zhou, X, Nie, Z, Roberts, A, Zhang, D, Sebat, J, Malhotra, D, et al. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Hum Mol Genet
2010; 19: 3797–805.
10
Blackwood, DH, Fordyce, A, Walker, MT, St Clair, DM, Porteous, DJ, Muir, WJ. Schizophrenia and affective disorders – cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet
2001; 69: 428–33.
11
Millar, JK, Christie, S, Anderson, S, Lawson, D, Hsiao-Wei Loh, D, Devon, RS, et al. Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. Mol Psychiatry
2001; 6: 173–8.
12
Fusté, M, Pinacho, R, Meléndez-Pérez, I, Villalmanzo, N, Villalta-Gil, V, Haro, JM, et al. Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis. J Psychiatr Res
2013; 47: 1608–14.
13
Zhou, X, Long, JM, Geyer, MA, Masliah, E, Kelsoe, JR, Wynshaw-Boris, A, et al. Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Mol Psychiatry
2005; 10: 393–406.
14
First, MB, Spitzer, RL, Gibbon, M, Williams, JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). Biometrics Research, New York State Psychiatric Institute, 2002.
15
International HapMap Consortium. The International HapMap Project. Nature
2003; 426: 789–96.
16
de Bakker, PI, Yelensky, R, Pe'er, I, Gabriel, SB, Daly, MJ, Altshuler, D. Efficiency and power in genetic association studies. Nat Genet
2005; 37: 1217–23.
17
de Bakker, PI, Burtt, NP, Graham, RR, Guiducci, C, Yelensky, R, Drake, JA, et al. Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet
2006; 38: 1298–303.
18
Shi, YY, He, L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res
2005; 15: 97–8.
19
Li, Z, Zhang, Z, He, Z, Tang, W, Li, T, Zeng, Z, et al. A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res
2009; 19: 519–23.
20
Falush, D, Stephens, M, Pritchard, JK. Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics
2003; 164: 1567–87.
21
Falush, D, Stephens, M, Pritchard, JK. Inference of population structure using multilocus genotype data: dominant markers and null alleles. Mol Ecol Notes
2007; 7 574–8.
22
Hubisz, MJ, Falush, D, Stephens, M, Pritchard, JK. Inferring weak population structure with the assistance of sample group information. Mol Ecol Resour
2009; 9: 1322–32.
23
Cannon, TD, Keller, MC. Endophenotypes in the genetic analyses of mental disorders. Annu Rev Clin Psychol
2006; 2: 267–90.
24
Heisler, LE, Torti, D, Boutros, PC, Watson, J, Chan, C, Winegarden, N, et al. CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic Acids Res
2005; 33: 2952–61.
25
Bouwman, P, Philipsen, S. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol
2002; 195: 27–38.
26
Black, AR, Black, JD, Azizkhan-Clifford, J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol
2001; 188: 143–60.
27
Supp, DM, Witte, DP, Branford, WW, Smith, EP, Potter, SS. Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol
1996; 176: 284–99.
28
Heintz, N. Gene expression nervous system atlas (GENSAT). Nat Neurosci
2004; 7: 483.
29
Zhu, H, Nguyen, VT, Brown, AB, Pourhosseini, A, Garcia, AV, van Bilsen, M, et al. A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene. Mol Cell Biol
1993; 13: 4432–44.
30
Ben-Shachar, D, Karry, R. Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2. PLoS One
2007; 2: e817.
31
Pinacho, R, Villalmanzo, N, Roca, M, Iniesta, R, Monje, A, Haro, JM, et al. Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms. J Psychiatr Res
2013; 47: 926–34.
32
Mao, X, Yang, SH, Simpkins, JW, Barger, SW. Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Spfamily transcription factors in neurons. J Neurochem
2007; 100: 1300–14.
33
Braff, DL, Geyer, MA, Swerdlow, NR. Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl)
2001; 156: 234–58.
34
Geyer, MA, Krebs-Thomson, K, Braff, DL, Swerdlow, NR. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl)
2001; 156: 117–54.
35
Dempster, EL, Toulopoulou, T, McDonald, C, Bramon, E, Walshe, M, Wickham, H, et al. Episodic memory performance predicted by the 2bp deletion in exon 6 of the “alpha 7-like” nicotinic receptor subunit gene. Am J Psychiatry
2006; 163: 1832–4.
36
Robles, O, Blaxton, T, Adami, H, Arango, C, Thaker, G, Gold, J. Nonverbal delayed recognition in the relatives of schizophrenia patients with or without schizophrenia spectrum. Biol Psychiatry
2008; 63: 498–504.
37
Daumas, S, Halley, H, Lassalle, JM. Disruption of hippocampal CA3 network: effects on episodic-like memory processing in C57BL/6J mice. Eur J Neurosci
2004; 20: 597–600.
38
Mao, X, Moerman-Herzog, AM, Wang, W, Barger, SW. Differential transcriptional control of the superoxide dismutase-2 kappaB element in neurons and astrocytes. J Biol Chem
2006; 281: 35863–72.
Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population
eLetters
No eLetters have been published for this article.