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Social Functioning and the Course of Early-Onset Schizophrenia

Five-year follow-up of a psychosocial intervention

Published online by Cambridge University Press:  02 January 2018

Marie E. Lenior*
Affiliation:
Academic Medical Center, University of Amsterdam, MFO Psychiatrie AMC/de Meren, The Netherlands
Peter M. A. J. Dingemans
Affiliation:
Academic Medical Center, University of Amsterdam, MFO Psychiatrie AMC/de Meren, The Netherlands
Don H. Linszen
Affiliation:
Academic Medical Center, University of Amsterdam, MFO Psychiatrie AMC/de Meren, The Netherlands
Lieuwe De Haan
Affiliation:
Academic Medical Center, University of Amsterdam, MFO Psychiatrie AMC/de Meren, The Netherlands
Aart H. Schene
Affiliation:
Academic Medical Center, University of Amsterdam, MFO Psychiatrie AMC/de Meren, The Netherlands
*
Marie E. Lenior, Psychiatric Center AMC, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
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Abstract

Background

Schizophrenia implies severe social impairments. Since the treatment of patients with schizophrenia shifted from long-term hospital admissions to community services, research on social functioning has become increasingly important.

Aims

Follow-up assessment of social functioning in young patients with schizophrenia during a 5-year period after intervention.

Method

During intervention, families were randomised into two conditions: standard intervention and standard plus family intervention.

Results

Although no differential treatment effect with regard to the course of the illness was found, patients from the standard plus family intervention condition stayed for fewer months in institutions for psychiatric patients than patients from the standard intervention condition.

Conclusions

Family intervention has helped parents to support their children, thereby diminishing institutional care.

Type
Papers
Copyright
Copyright © Royal College of Psychiatrists, 2001 

For many years research on schizophrenia was focused on psychotic symptoms (Reference StraussStrauss, 1975; Reference Engelhardt and RosenEngelhardt & Rosen, 1976). However, schizophrenia implies severe psychosocial limitations. For this reason social functioning as an outcome measure in psychiatric research has gained attention. Engelhardt & Rosen (Reference Engelhardt and Rosen1976) remarked that psychosocial handicaps are the most severe consequences of schizophrenia. Strauss & Carpenter (Reference Strauss and Carpenter1974) noted that in research on the course of schizophrenic illness, social functioning is an important outcome measure. In this follow-up study we describe aspects of social functioning and the course of psychotic symptoms in young patients with early-onset schizophrenia and related disorders 5 years after intervention. The differential effect of two intervention conditions on social functioning and the course of the illness is evaluated. Finally, we investigate the association between social functioning and severity of the illness (e.g. diagnostic grouping and the course of the illness).

METHOD

Subjects

This study concerns the 5-year follow-up of a 15-month intervention in the Adolescent Clinic of the Psychiatric Department of the Academic Medical Center in Amsterdam. Before the controlled trial began, families were stratified into high and low expressed emotion (Reference Vaughn and LeffVaughn & Leff, 1976) and randomised into two conditions: standard intervention or standard plus behavioural family intervention. The intervention programme and the two intervention conditions are described in detail elsewhere (Reference Linszen, Dingemans and Van der DoesLinszen et al, 1996). Briefly, the programme consisted of a 3-month in-patient phase and an out-patient phase of 12 months. Family intervention consisted of supporting parents, and psychoeducation, training in communication skills and problem-solving techniques with families. After discharge, patients were referred to psychiatric services in their area of residence.

Of the 97 families who formerly underwent the intervention programme, 73 participated in the follow-up study, after giving written informed consent. Reasons for non-participation were: refusal (4), not traceable (10), emigration (1) and fatal accident (1). Furthermore, eight patients committed suicide: three (14%) from the group that was not randomised (see Reference Linszen, Dingemans and Van der DoesLinszen et al, 1996); two (5%) from families that received family intervention; and three (8%) from the standard intervention.

Data were available in 58 cases from the patient and one or two parents, and in 13 cases from one or two parents but without the patient. Two patients participated without their parent(s). On average, the interviews took place 7.9 (range 6-10) years after discharge.

The mean age of the patients (51 men and 22 women) at admission was 20.9 (range 16-26) years (Table 1), whereas the mean age at the time of the follow-up interview was 30.5 (range 26-37) years. The mean duration of untreated illness before admission was 5.4 months and half of the patients (52%) had their first psychotic episode before admission. At discharge from the intervention programme, the diagnoses (DSM-III-R; American Psychiatric Association, 1987) were: schizophrenia, 42 (58%); schizoaffective disorder, 15 (21%); schizophreniform disorder, 9 (12%); and other psychotic disorders (e.g. delusional disorder and atypical psychosis), 7 (10%).

Table 1 Demographic and psychiatric characteristics of participants and non-participants

All subjects (n=97) Non-participants (n=24) Participants (n=73) Test non-participants v.participants
Statistic1 P
Age at admission, mean (s.d.) 20.5 (2.5) 19.5 (2.6) 20.9 (2.4) 624 0.03
Gender, n(%)
Female 26 (27) 4 (17) 22 (30) 1.67 0.20
Male 71 (73) 20 (83) 51 (70)
Education, n(%)
< Secondary school 21 (22) 6 (25) 15 (21) 0.21 0.65
≥ Secondary school 76 (78) 18 (75) 58 (80)
Socio-economic status, n(%)
Low (III-V) 73 (75) 20 (83) 53 (73) 1.12 0.29
High (I-II) 24 (25) 4 (17) 20 (27)
Age of onset of schizophrenia, mean (s.d.) 19.1 (2.6) 18.5 (2.8) 19.3 (2.5) 759 0.32
Prior psychotic episodes, n(%)
None 55 (57) 17 (71) 38 (52) 2.59 0.11
One or more 42 (43) 7 (29) 35 (48)
Prior admissions, n(%)
None 57 (59) 18 (75) 39 (53) 3.47 0.06
One or more 40 (41) 6 (25) 34 (47)
DSM-III-R schizophrenia, n(%)
No 41 (42) 10 (42) 31 (42) <0.01 0.95
Yes 56 (58) 14 (58) 42 (58)
Months of untreated illness, mean (s.d.) 5.6 (10.2) 6.3 (6.1) 5.4 (11.2) 589 0.05
Sum score of positive and negative symptoms,2mean (s.d.) 15.1 (4.7) 15.6 (3.4) 14.9 (5.0) 730 0.22
Compliance with antipsychotic medication,3mean (s.d.) 3.7 (0.7) 3.4 (1.0) 3.8 (0.4) 665 0.04

Comparisons between participating patients and non-participants of the follow-up study showed that at admission participants were 1 year older on average than non-participants, that the duration of untreated psychosis was 1 month less on average and that compliance to medication during intervention was higher for participants than for non-participants. Regarding baseline data, no significant differences between the two intervention conditions were found.

Assessments

Patients and parents were interviewed with the Life Chart Schedule (LCS: World Health Organization, 1992). This instrument elicits data about symptoms, treatment (rehospitalisation, living in sheltered homes, out-patient treatment) and social conditions (employment, study, living arrangements) during a given period. Susser et al (Reference Susser, Finnerty and Mojtabai2000) showed that the LCS yields reliable ratings of the long-term course of schizophrenia when assessed by trained raters. Inconsistencies regarding symptoms and treatment (n=3) were cross-checked with current therapists.

The first follow-up study, which also included the LCS, was carried out in 1992. At that time the follow-up period differed for the successively admitted and discharged patients (17-55 months). At the second follow-up, held in 1997-1998, the data were completed up to and including 5 years after discharge. If the patient and/or parent(s) had participated in 1992, which was the case for all but one patient, the data of that interview were first examined and completed for the 5-year period.

The course of the illness was divided into psychotic and non-psychotic episodes. A psychotic episode was characterised by clearly reported positive symptoms, i.e. delusions, hallucinations and/or formal thought disorders (Reference Nuechterlein, Snyder and DawsonNuechterlein et al, 1986). A non-psychotic episode was a period without positive symptoms, with or without residual symptoms and/or negative symptoms. A non-psychotic episode had to last at least 30 days (Reference Wiersma, Nienhuis and SlooffWiersma et al, 1998). When there was never a 30-day remission period during follow-up, the patient was considered as having chronic positive symptoms (60 months).

The LCS data were first rated for relapses by one of the authors (D. H. L.) and rated again by a psychiatrist (L.d. H.), who was employed 2 years after the intervention and had not been involved with the patients. Regarding clinical status (no relapse, one or more relapses, chronic), there was disagreement about six patients (8%). For 16 (22%) patients the number of months with psychotic symptoms differed (mean absolute difference=6.7; s.d.=6.8). For the 22 patients about whom there was disagreement, consensus was achieved by re-examination of the data by both raters together.

Analyses

For analyses concerning social functioning, three composite scores were calculated: living in institutions for psychiatric patients (months in mental hospitals and/or sheltered homes); structural activities (months of full-time, part-time or voluntary work, full-time study and/or housekeeping); help from the family (sum score of help with activities of daily living, accompanying to out-patient services, checking intake of medication and management of care). The four items concerning help from the family were scored as follows: 1, ‘none’; 2, ‘part of period’; 3, ‘majority of period’ (Table 2).

Table 2 Socio-demographic characteristics according to the Life Chart Schedule (World Health Organization, 1992) during the 60-month follow-up period (n=73)

Item Category Mean (n) s.d. (%)
Living arrangements
Months within the community 41.8 20.0
With parents1 No 43 63
Yes 25 37
Work
Paid jobs Never 39 53
Some period 34 47
Months of full-time jobs 5.2 12.8
Months of part-time jobs 4.8 9.6
Performance in jobs held2 Poor 9 26
Good 17 50
Very good 8 24
Type of usual job2 Unskilled 7 21
Semi-skilled 14 41
Skilled 13 38
Level of usual job2 Much lower 6 18
Lower 16 47
About the same 12 35
Months of full-time housekeeping3 2.1 8.9
Global score for work/housekeeping4 Poor 17 25
Fair 36 52
Good 16 23
Months of voluntary work 7.6 11.7
Months of full-time study 6.7 15.1
Months of receiving disability pension 40.2 25.9
Months unemployed 6.8 15.8
Follow-up treatment
Months in mental hospital 7.8 11.6
Number of hospital admissions 1.4 1.7
Duration of longest admission (months) 5.5 9.0
Months in sheltered homes 9.5 16.7
Day treatment Never 41 56
Some period 32 44
Out-patient services Never 17 23
Some period 56 77
Family therapy Never 64 88
Some period 9 12
Help from the family
Daily activities None 23 32
Part of period 27 37
Majority of period 23 32
Accompanying for out-patient services None 41 56
Part of period 24 33
Majority of period 8 11
Checking medication compliance None 48 66
Part of period 19 26
Majority of period 6 8
Management of care None 46 63
Part of period 14 19
Majority of period 13 18

The duration of psychotic episodes is an important indicator of the severity of the illness. Therefore the course of the illness was expressed as the number of months that patients had psychotic symptoms. For chronic patients this was 60 months.

Mann—Whitney U-tests were used to compare the three areas of social functioning by intervention condition and by diagnosis group (schizophreniav. schizophrenia-like disorder) as classified at discharge. Testing associations between the three areas of social functioning and the total duration of psychotic episodes was done by Spearman's rank correlations (ρ).

RESULTS

On average, patients lived within the community for 42 of the 60 months (Table 2). Of the patients, 40% lived alone for the major part of the 5-year period; 34% lived for the most part with parent(s); 12% lived with a partner; 7% lived otherwise (not in institutions for psychiatric patients); and 7% lived for the total 5-year period in institutions for psychiatric patients. Seven patients were homeless for some days (n=3) or some months (n=4), meaning that they had no steady place of residence during that period, or that their place of residence was unknown. One patient stayed in prison for 1 month.

Of the patients, 34 held a paid job for at least some period. For these patients the occupational level in 65% of the cases was lower than their level of education: in 62% of the cases, unskilled or semi-skilled jobs. For 74% of the patients who held a paid job, the performance of their work was qualified as ‘good’ to ‘very good’ by patient and/or parent(s). This qualification is related to the level of the work (e.g. working in shops, catering, warehouses, light office jobs). Six patients did the housekeeping full-time during some period of the 5 years. For only one of them was the performance in housekeeping qualified as ‘poor’. In the 5-year period 21 patients followed full-time study for some of the time. The mean number of months during which patients had structural activities was 26.2 (s.d.=20.0; range=0-60). This implies that they had no structural activities for almost 3 years (34 months).

As mentioned, five patients stayed in institutions for psychiatric patients for 60 months. The patient group stayed for 8 months on average in mental hospitals and for 10 months in sheltered homes. The mean number of months that patients stayed in institutions for psychiatric patients was 17.3 (s.d.=19.4; range=0-60).

During follow-up, patients required some help from their families, mainly parents. Of the patients, 69% received help with the performance of daily activities, mainly housekeeping, almost half of them (32%) during the major part of the 5-year period. Almost half of the patient group (44%) was accompanied by parent(s) when having an appointment for out-patient services. Many parents (34%) checked medication compliance. Finally, it appeared that in 37% of the cases the parents helped the patient with seeking help or making decisions about treatment. The mean sum score for help from the family was 6.5 (s.d.=2.2; range=4-12).

A quarter of the patients (n=19) did not have a psychotic episode during follow-up, half of them (n=36) had one or more episodes and a quarter (n=18) had chronic positive symptoms. In the 55 non-chronic cases, the relapse rate was 42% after 2 years and 65% after 5 years (Fig. 1). If we include chronic cases, 26% did not have a relapse in the 5-year period. For all patients the mean total duration of psychotic episodes was 19.2 (s.d.=24.5; range=0-60) months.

Fig. 1 Kaplan—Meier curve of relapses of patients without chronic positive symptoms (n=55).

Intervention condition had no effect on psychotic episodes (Table 3). Patients at discharge who had a diagnosis of schizophrenia had 14 more months of psychotic symptoms, on average, than patients with other diagnoses. This is related to the fact that the 42 patients with a diagnosis of schizophrenia more often had a chronic course than the 31 patients with a schizophrenia-like disorder (33%v. 13%; χ2=4.01; d.f.=1; P=0.05).

Table 3 Total duration of psychotic episodes (in months) during 60 months of follow-up by intervention condition and by diagnostic group (n=73)

n Mean s.d. U 1 P
Intervention condition2
Standard 33 18.82 24.29 470 0.57
Standard+family 31 16.35 23.15
Schizophrenia3
No 31 11.23 19.77 431 0.01
Yes 42 25.05 26.09

For structural activities and help from the family, no significant differences were found between intervention conditions (Table 4). For patients who received additional family intervention, the number of months spent in institutions for psychiatric patients was 10 months less, on average, than for patients from the standard condition.

Table 4 Social functioning during 60 months of follow-up by intervention condition and by diagnostic group (n=73)

Living in institutions for psychiatric patients (months) Structural activities (months) Help from the family (sum score)
n Mean s.d. U 1 P Mean s.d. U 1 P Mean s.d. U 1 P
Intervention condition2
Standard 33 21.18 20.34 363 0.04 21.94 18.70 408 0.16 6.48 2.12 504 0.92
Standard+family 31 10.87 16.15 28.84 19.96 6.45 2.16
Schizophrenia3
No 31 12.13 15.76 479 0.05 28.65 19.47 553 0.27 5.84 1.86 456 0.03
Yes 42 21.07 21.10 24.45 20.40 7.02 2.32

Comparisons between diagnostic subgroups (Table 4) reveal that patients with a diagnosis of schizophrenia spent almost 9 months longer in institutions for psychiatric patients than patients with other diagnoses. They also received more help from their families. For structural activities the difference was not significant.

Correlations between total duration of psychotic episodes and the three areas of social functioning indicate that patients with a longer duration of psychotic symptoms spent longer in institutions for psychiatric patients (ρ=0.30; P=0.01), had shorter periods of structural activities (ρ=-0.34; P=0.003) and received more help from their families (ρ=0.38; P=0.001) than patients with a shorter duration of psychotic symptoms.

DISCUSSION

Social functioning and course of illness

The results show patients with schizophrenia or a schizophrenia-like disorder to have considerable social limitations. For the young adults in our study parents appear to play an important role in supporting their offspring, in activities of daily living as well as in matters of follow-up treatment. Structural activities were rather scarce in this patient group: patients had no structural activities for almost 3 of the 5 years. This indicates that more attention should be paid to opportunities to activate and to support individuals who stay in the community to find structural activities, whether paid or unpaid. Voluntary, unpaid work appears to be an important activity. The number of months that this type of work was done was higher than the number of months in paid jobs. Voluntary jobs are important, because they give patients a feeling of worth and raise their sense of accomplishment. They also offer patients the opportunity to structure their life.

An earlier study (Reference Linszen, Dingemans and Van der DoesLinszen et al, 1996) showed that relapses could be delayed during intervention: 16% of the patients relapsed during the 12-month out-patient phase of the intervention. The results of the present study show that this beneficial effect did not last. After 2 years, 42% of the patients had a relapse. In a review, Mari & Streiner (Reference Mari and Streiner1994) reported relapse rates of 47-53% within 2 years. In another study with Dutch patients (Reference Wiersma, Nienhuis and SlooffWiersma et al, 1998) the relapse rate after 5 years was 72%, which is higher than our relapse rate (65%). Robinson et al (Reference Robinson, Woerner and Alvir1999) found a higher relapse rate of 82%. Thus, the relapse rate in our study is still lower than in other studies. However, the results of the present study are congruent with the observation of McGlashan & Johannessen (Reference McGlashan and Johannessen1996) that interventions are effective as long as they are active.

Effect of family intervention

Patients who had received additional family intervention spent fewer months in institutions for psychiatric patients than patients who had had the standard intervention. Falloon et al (Reference Falloon, Boyd and McGill1982), Tarrier et al (Reference Tarrier, Barrowclough and Vaughn1989) and Xiong et al (Reference Xiong, Phillips and Hu1994) also found this effect, in combination with a differential effect on the occurrence of relapses. Falloon et al (Reference Falloon, Boyd and McGill1982) suggested that the reduction of stress in families who received family intervention prevented relapses and rehospitalisation. Our results do not confirm this supposition completely, because the intervention condition did not affect the relapse rate. Because families were allocated randomly to the two conditions, we may conclude that parents who received family intervention were better equipped to support their child, but it is hard to say how. In any case, it appears that in certain cases rehospitalisation or admissions to institutions for psychiatric patients can be prevented or delayed.

A number of studies showed that family intervention improved the social functioning of patients with schizophrenia (Reference Falloon, McGill and BoydFalloon et al, 1987; Reference Barrowclough and TamerBarrowclough & Tarrier, 1990; Reference Xiong, Phillips and HuXiong et al, 1994). Falloon et al (Reference Falloon, McGill and Boyd1987) hypothesised that the problem-solving techniques of the family intervention caused a reduction in positive as well as in negative symptoms, so that patients were able to focus on their social condition. Leff et al (Reference Leff, Berkowitz and Shavit1989) suggested that social functioning depends on negative symptoms, which diminish more slowly than positive symptoms. This supposition was confirmed by Poque-Geile & Harrow (Reference Poque-Geile and Harrow1984) and by Bellack et al (Reference Bellack, Morrison and Wixted1990). Although negative symptoms were not included in our study, a possible explanation for the absence of association between intervention condition and social functioning (i.e. structural activities for help from the family) might be that the family intervention was focused on the reduction of family stress and not particularly on social rehabilitation. However, in both intervention conditions the patients were given help with seeking education, employment and financial support.

Severity of illness and social functioning

For patients with a poorer course of the illness, whether as predicted by diagnosis at discharge or as indicated by the number of months with psychotic symptoms thereafter, social functioning was worse than for patients with a more favourable course of the illness. Possible explanations for this relationship were found in the literature.

Johnstone et al (Reference Johnstone, MacMillan and Frith1990) found that occupational functioning was better in patients who received a placebo than in patients on neuroleptic medication. Barrowclough & Tarrier (Reference Barrowclough and Tamer1990) found a negative association between dose of medication and social functioning. They argued that the tranquillising effect of neuroleptics could decrease the level of activities. In our study the influence of neuroleptic medication could not be assessed, because the LCS comprises only two global items about the prescription of medication. It is possible that patients with more months of psychotic symptoms took higher doses of neuroleptic medication, which could have affected their social functioning.

Bellack et al (Reference Bellack, Morrison and Wixted1990) mentioned two possible hypotheses: impairment of social functioning as a consequence of negative symptoms or as a consequence of deficits in social skills. Although the association between negative symptoms and social functioning was demonstrated, support was found also for the social deficits hypothesis. No conclusions about the effect of negative symptoms can be drawn from our study, because these symptoms were not assessed for patients with chronic positive symptoms. However, patients with longer periods of positive symptoms functioned less well in the three areas of social functioning than patients with shorter periods of positive symptoms. Therefore, we cannot discount the role of positive symptoms.

Clinical Implications and Limitations

CLINICAL IMPLICATIONS

  1. For patients with early-onset schizophrenia discontinuity of care may have a deleterious effect on the course of the illness. The results of the present study are congruent with the observation of others that interventions are effective as long as they are active.

  2. Family intervention for patients with schizophrenia, although not specifically focused on social rehabilitation, may diminish institutional care.

  3. Patients with schizophrenia who stay in the community after a short period in mental hospital need help in several areas. Interventions should focus not only on psychiatric symptoms but also on social rehabilitation.

LIMITATIONS

  1. The family intervention consisted of three ingredients — psychoeducation, training in communication skills and problem-solving techniques — and was contrasted with the standard intervention. The design of the study does not allow us to designate which part of the intervention was active in delaying rehospitalisation.

  2. Negative symptoms may have an effect on social functioning. With the Life Chart Schedule (LCS), negative symptoms were investigated only in a global way and only for patients without chronic positive symptoms.

  3. In this study medication compliance, an important predictor of the course of the illness, was not assessed adequately with the LCS.

Footnotes

Declaration of interest

This study was funded by grants 28-1241-1 and 28-1241-2 from the Dutch Health Research and Development Council and by the Dutch Ministry of Welfare, Health and Cultural Affairs (Project 90-120; CRO 504581).

References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Barrowclough, C. & Tamer, N. (1990) Social functioning in schizophrenic patients. I. The effects of expressed emotion and family intervention. Social Psychiatry and Psychiatric Epidemiology, 25, 125129.CrossRefGoogle ScholarPubMed
Bellack, A. S., Morrison, R. L., Wixted, T. J., et al (1990) An analysis of social competence in schizophrenia. British Journal of Psychiatry, 156, 809818.CrossRefGoogle Scholar
Breier, A., Schreiber, J. L., Dyer, J., et al (1991) National Institute of Mental Health longitudinal study of chronic schizophrenia. Prognosis and predictors of outcome. Archives of General Psychiatry, 48, 239246.CrossRefGoogle ScholarPubMed
Engelhardt, D. M. & Rosen, B. (1976) Implications of drug treatment for the social rehabilitation of schizophrenic patients. Schizophrenia Bulletin, 2, 454462.CrossRefGoogle ScholarPubMed
Falloon, I. R. H., Boyd, J. L., McGill, C. W., et al (1982) Family management in the prevention of exacerbations of schizophrenia. New England Journal of Medicine, 306, 14371440.CrossRefGoogle ScholarPubMed
Falloon, I. R. H., McGill, C. W., Boyd, J. L., et al (1987) Family management in the prevention of morbidity of schizophrenia: social outcome of a two-year longitudinal study. Psychological Medicine, 17, 5966.CrossRefGoogle ScholarPubMed
Johnstone, E. C., MacMillan, J. F., Frith, C. D., et al (1990) Further investigation of the predictors of outcome following first schizophrenic episodes. British Journal of Psychiatry, 157, 182189.CrossRefGoogle ScholarPubMed
Leff, J., Berkowitz, R., Shavit, N., et al (1989) Atrial of family therapy v. a relatives group for schizophrenia. British Journal of Psychiatry, 154, 5866.CrossRefGoogle Scholar
Linszen, D., Dingemans, P., Van der Does, J. W., et al (1996) Treatment, expressed emotion and relapse in recent onset schizophrenic disorders. Psychological Medicine, 26, 333342.CrossRefGoogle ScholarPubMed
Mari, J. J. & Streiner, D. L. (1994) An overview of family interventions and relapse on schizophrenia: meta-analysis of research findings. Psychological Medicine, 24, 565578.CrossRefGoogle ScholarPubMed
McGlashan, T. H. & Johannessen, J. O. (1996) Early detection and intervention with schizophrenia: rationale. Schizophrenia Bulletin, 22, 201222.CrossRefGoogle ScholarPubMed
Nuechterlein, K. H., Snyder, K. S., Dawson, M. E., et al (1986) Expressed emotion, fixed-dose fluphenazine decanoate maintenance, and relapse in recent-onset schizophrenia. Psychopharmacology Bulletin, 22, 633639.Google ScholarPubMed
Poque-Geile, M. F. & Harrow, M. (1984) Negative and positive symptoms in schizophrenia and depression: a followup. Schizophrenia Bulletin, 10, 371387.CrossRefGoogle Scholar
Robinson, D., Woerner, M. G., Alvir, J. M. J., et al (1999) Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Archives of General Psychiatry, 56, 241247.CrossRefGoogle ScholarPubMed
Strauss, J. S. (1975) A comprehensive approach to psychiatric diagnosis. American Journal of Psychiatry, 132, 11931197.Google ScholarPubMed
Strauss, J. S. & Carpenter, W. T. Jr. (1974) The prediction of outcome in schizophrenia. II. Relationship between predictor and outcome variables: a report from the WHO International Pilot Study of Schizophrenia. Archives of General Psychiatry, 31, 3742.CrossRefGoogle Scholar
Susser, E., Finnerty, M., Mojtabai, R., et al (2000) Reliability of the Life Chart Schedule for assessment of the long-term course of schizophrenia. Schizophrenia Research, 42, 6777.CrossRefGoogle ScholarPubMed
Tarrier, N., Barrowclough, C., Vaughn, C., et al (1989) Community management of schizophrenia. A two-year follow-up of a behavioural intervention with families. British Journal of Psychiatry, 154, 625628.CrossRefGoogle ScholarPubMed
Vaughn, C. E. & Leff, J. P. (1976) The measurement of expressed emotion in the families of psychiatric patients. British Journal of Social and Clinical Psychology, 15, 157165.CrossRefGoogle ScholarPubMed
Wiersma, D., Nienhuis, F. J., Slooff, C. J., et al (1998) Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort. Schizophrenia Bulletin, 24, 7585.CrossRefGoogle ScholarPubMed
World Health Organization (1992) WHO Coordinated Multi-Center Study on the Course and Outcome of Schizophrenia. Geneva: WHO.Google Scholar
Xiong, W., Phillips, M. R., Hu, X., et al (1994) Family-based intervention for schizophrenic patients in China. A randomised controlled trial. British Journal of Psychiatry, 165, 239247.CrossRefGoogle Scholar
Figure 0

Table 1 Demographic and psychiatric characteristics of participants and non-participants

Figure 1

Table 2 Socio-demographic characteristics according to the Life Chart Schedule (World Health Organization, 1992) during the 60-month follow-up period (n=73)

Figure 2

Fig. 1 Kaplan—Meier curve of relapses of patients without chronic positive symptoms (n=55).

Figure 3

Table 3 Total duration of psychotic episodes (in months) during 60 months of follow-up by intervention condition and by diagnostic group (n=73)

Figure 4

Table 4 Social functioning during 60 months of follow-up by intervention condition and by diagnostic group (n=73)

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