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The Strength of the Genetic Effect: Is There Room for an Environmental Influence in the Aetiology of Schizophrenia?

  • Peter Mcguffin (a1), Philip Asherson (a2), Michael Owen (a3) and Anne Farmer (a4)
Abstract

The evidence for a genetic contribution to schizophrenia is compelling. However, the pattern of inheritance is complex and it is usually assumed that environmental factors also have a role that will eventually be identified. We argue that this is not necessarily the case. While a hypothesis combining genetic diathesis with environmental stress cannot be disproved, it is also possible that ‘non-genetic’ factors consist entirely of stochastic events affecting gene expression or structure.

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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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The Strength of the Genetic Effect: Is There Room for an Environmental Influence in the Aetiology of Schizophrenia?

  • Peter Mcguffin (a1), Philip Asherson (a2), Michael Owen (a3) and Anne Farmer (a4)
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