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Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis

  • Tsutomu Takahashi (a1), Stephen J. Wood (a2), Alison R. Yung (a3), Mark Walterfang (a3), Lisa J. Phillips (a4), Bridget Soulsby (a5), Yasuhiro Kawasaki (a6), Patrick D. McGorry (a3), Michio Suzuki (a6), Dennis Velakoulis (a5) and Christos Pantelis (a5)...
Abstract
Background

Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear.

Aims

To determine whether individuals exhibit superior temporal gyral changes before the onset of psychosis.

Method

We used magnetic resonance imaging to examine grey matter volumes of the superior temporal gyrus and its subregions (planum polare, Heschl's gyrus, planum temporale, and rostral and caudal regions) in 97 antipsychotic-naive individuals at ultra-high risk of psychosis, of whom 31 subsequently developed psychosis and 66 did not, and 42 controls.

Results

Those at risk of psychosis had significantly smaller superior temporal gyri at baseline compared with controls bilaterally, without any prominent subregional effect; however, there was no difference between those who did and did not subsequently develop psychosis.

Conclusions

Our findings indicate that grey matter reductions of the superior temporal gyrus are present before psychosis onset, and are not due to medication, but these baseline changes are not predictive of transition to psychosis.

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Copyright
Corresponding author
Dr Tsutomu Takahashi, Melbourne Neuropsychiatry Centre, c/o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia. E-mail: tsutomu@med.u-toyama.ac.jp
Footnotes
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The study was supported by project grants from the National Health and Medical Research Council (NHMRC) (grants 145627, 145737, 970598, 981112, 970391), NHMRC programme grant 350241 and the Colonial Foundation. D.V. and S.J.W. were supported as research officers with funding from the NHMRC. M.W. was supported by a Stanley Research Centre grant. P.D.M. was supported by an NARSAD Distinguished Investigator Award. S.J.W. is currently supported by a Clinical Career Development Award from the NHMRC (359223) and an NARSAD Young Investigator Award. T.T. was supported to undertake this work by a grant-in-aid for scientific research (19591346) from the Japanese Society for the Promotion of Science, and a research grant (17-2, 18-6) for nervous and mental disorders from the Ministry of Health and Welfare, Japan.

Declaration of interest

None.

Footnotes
References
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Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis

  • Tsutomu Takahashi (a1), Stephen J. Wood (a2), Alison R. Yung (a3), Mark Walterfang (a3), Lisa J. Phillips (a4), Bridget Soulsby (a5), Yasuhiro Kawasaki (a6), Patrick D. McGorry (a3), Michio Suzuki (a6), Dennis Velakoulis (a5) and Christos Pantelis (a5)...
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