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The truth about genetic variation in the serotonin transporter gene and response to stress and medication

  • Peter McGuffin (a1), Shaza Alsabban (a1) and Rudolf Uher (a1)
Summary

The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.

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Copyright
Corresponding author
Peter McGuffin, MRC SGDP Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. Email: peter.mcguffin@kcl.ac.uk
Footnotes
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See pp. 464–471, this issue.

Declaration of interest

P.M. and R.U. have received research funding from the Innovative Medicines Initiative Joint Undertaking (IMI) under Grant Agreement No. 115008.

Footnotes
References
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The British Journal of Psychiatry
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  • EISSN: 1472-1465
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The truth about genetic variation in the serotonin transporter gene and response to stress and medication

  • Peter McGuffin (a1), Shaza Alsabban (a1) and Rudolf Uher (a1)
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