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Twenty-five year mortality of a community cohort with schizophrenia

  • Steve Brown (a1), Miranda Kim (a2), Clemence Mitchell (a3) and Hazel Inskip (a4)

Abstract

Background

People with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s.

Aims

To measure the 25-year mortality of people with schizophrenia with particular focus on changes over time.

Method

Prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia.

Results

The cohort had an all-cause standardised mortality ratio of 289 (95% CI 247–337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population (P = 0.053) over the course of the study.

Conclusions

People with schizophrenia have a mortality risk that is two to three times that of the general population. Most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health.

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Copyright

Corresponding author

Steve Brown, Cannon House, 6 Cannon Street, Shirley, Southampton S015 5PQ, UK. Email: steve.brown@hantspt-sw.nhs.uk

Footnotes

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Declaration of interest

None.

Footnotes

References

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Twenty-five year mortality of a community cohort with schizophrenia

  • Steve Brown (a1), Miranda Kim (a2), Clemence Mitchell (a3) and Hazel Inskip (a4)

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