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A critical review of pharmacotherapy for major depressive disorder

  • Jamie M. Dupuy (a1), Michael J. Ostacher (a2), Jeffrey Huffman (a1), Roy H. Perlis (a1) and Andrew A. Nierenberg (a1)...
Abstract
Abstract

Newer generation antidepressant drugs, with improvements in safety and tolerability, have replaced tricyclic antidepressants as first-line treatment of depressive illness. However, no single antidepressant drug from any class has distinguished itself as the obvious first-line treatment of major depression. The choice of therapy is driven primarily by patient choice, with informed consent for the risks of adverse effects. Cost has become an additional factor in this decision as several of the newer antidepressant drugs are now available in generic form. Several augmentation and drug-switching strategies have demonstrated benefit in refractory illness. While no single strategy distinguished itself as superior to the others, some have been more rigorously tested. Ongoing efforts at improving effectiveness, time to response, and tolerability have led to novel drug therapies. Efforts at characterizing predictors of treatment outcomes now include pharmacogenetic studies.

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Corresponding author
Address for correspondence: J. M. Dupuy, M.D., Massachusetts General Hospital, Bipolar Clinic and Research Program, 50 Staniford Street, Suite 580, Boston, MA 02114. Tel.: 617-643-6257Fax: 617-726-6768Email: jdupuy@partners.org
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G Abraham , R Milev , J Stuart Lawson (2006). T3 augmentation of SSRI resistant depression. Journal of Affective Disorders 91, 211215.

CB Aiken (2007). Pramipexole in psychiatry: a systematic review of the literature. Journal of Clinical Psychiatry 68, 12301236.

LL Altshuler , M Bauer , MA Frye , MJ Gitlin , (2001). Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature. American Journal of Psychiatry 158, 16171622.

IM Anderson (1998). SSRIs vs. tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability. Depression and Anxiety 7 (Suppl. 1), 1117.

IM Anderson (2000). Selective serotonin reuptake inhibitors vs. tricyclic antidepressants: a meta-analysis of efficacy and tolerability. Journal of Affective Disorders 58, 1936.

J Angst , A Gamma , R Sellaro , PW Lavori , (2003). Recurrence of bipolar disorders and major depression. A life-long perspective. European Archives of Psychiatry and Clinical Neuroscience 253, 236240.

JS Ballon , D Feifel (2006). A systematic review of modafinil: Potential clinical uses and mechanisms of action. Journal of Clinical Psychiatry 67, 554566.

L Barbosa , M Berk , M Vorster (2003). A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. Journal of Clinical Psychiatry 64, 403407.

LL Carpenter , S Yasmin , LH Price (2002). A double-blind, placebo-controlled study of antidepressant augmentation with mirtazapine. Biological Psychiatry 51, 183188.

A Cipriani , TA Furukawa , G Salanti , JR Geddes , (2009). Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 373, 746758.

CU Correll , S Leucht , JM Kane (2004). Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of one-year studies. American Journal of Psychiatry 161, 414415.

MH Corrigan , AQ Denahan , CE Wright , RJ Ragual , (2000). Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depression and Anxiety 11, 5865.

NA Crossley , M Bauer (2007). Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials. Journal of Clinical Psychiatry 68, 935940.

C DeBattista , K Doghramji , MA Menza , MH Rosenthal , (2003). Adjunct modafinil for the short-term treatment of fatigue and sleepiness in patients with major depressive disorder: a preliminary double-blind, placebo-controlled study. Journal of Clinical Psychiatry 64, 10571064.

C DeBattista , J Hawkins (2009). Utility of atypical antipsychotics in the treatment of resistant unipolar depression. CNS Drugs 23, 369377.

C DeBattista , A Lembke , HB Solvason , R Ghebremichael , (2004). A prospective trial of modafinil as an adjunctive treatment of major depression. Journal of Clinical Psychopharmacology 24, 8790.

S Elgamal , G MacQueen (2008). Galantamine as an adjunctive treatment in major depression. Journal of Clinical Psychopharmacology 28, 357359.

M Fava , AJ Rush , SR Wisniewski , AA Nierenberg , (2006). A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report. American Journal of Psychiatry 163, 11611172.

M Fava , ME Thase , C DeBattista (2005). A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness. Journal of Clinical Psychiatry 66, 8593.

D Fergusson , S Doucette , K Cranley Glass , S Shapiro , (2005). Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomized controlled trials. British Medical Journal 330, 396.

JC Fournier , RJ DeRubeis , SD Hollon , S Dimidjian , (2010). Antidepressant drug effects and depression severity: a patient-level meta-analysis. Journal of the American Medical Association 303, 4753.

G Gartlehner , BN Gaynes , RA Hansen , P Thieda , (2008). Comparative benefits and harms of second-generation antidepressants: background paper for the American College of Physicians. Annals of Internal Medicine 149, 734750.

JR Geddes , SM Carney , C Davies , TA Furukawa , (2003). Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet 361, 653661.

RD Gibbons , CH Brown , K Hur , SM Marcus , (2007). Early evidence on the effects of regulators’ suicidality warnings on SSRI prescriptions and suicide in children and adolescents. American Journal of Psychiatry 164, 13561363.

RD Gibbons , K Hur , DK Bhaumik , JJ Mann (2005). The relationship between antidepressant medication use and rate of suicide. Archives of General Psychiatry 62, 165172.

RD Gibbons , K Hur , DK Bhaumik , JJ Mann (2006). The relationship between antidepressant prescription rates and rate of early adolescent suicide. American Journal of Psychiatry 163, 18981904.

GM Goodwin , R Emsley , S Rembry , F Rouillon , (2009). Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychiatry 70, 11281137.

F Guzzetta , L Tondo , F Centorrino , RJ Baldessarini (2007). Lithium treatment reduces suicide risk in recurrent major depressive disorder. Journal of Clinical Psychiatry 68, 380383.

R Hansen , B Gaynes , P Thieda , G Gartlehner , (2008). Meta-analysis of major depressive disorder relapse and recurrence with second-generation antidepressants. Psychiatric Services 59, 11211130.

K Hashimoto (2009). Emerging role of glutamate in the pathophysiology of major depressive disorder. Brain Research Reviews 61, 105123.

PE Holtzheimer 3rd, TW Meeks , ME Kelley , M Mufti , (2008). A double blind, placebo-controlled pilot study of galantamine augmentation of antidepressant treatment in older adults with major depression. International Journal of Geriatric Psychiatry 23, 625631.

DV Iosifescu , AA Nierenberg , D Mischoulon , RH Perlis , (2005). An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. Journal of Clinical Psychiatry 66, 10381042.

L Judd , HS Akiskal , JD Maser , PJ Zeller , (1998). A prospective 12-year study of subsyndromal and syndromal depressive symptoms in unipolar major depressive disorders. Journal of Affective Disorders 50, 97108.

MB Keller , PW Lavori , CE Lewis , GL Klerman (1983). Predictors of relapse in major depressive disorder. Journal of the American Medical Association 250, 32993304.

N Kennedy , ES Paykel (2004). Residual symptoms at remission from depression: impact on long-term outcome. Journal of Affective Disorders 80, 135144.

SH Kennedy , S Rizvi , K Fulton , J Rasmussen (2008). A double-blind comparison of sexual functioning, antidepressant efficacy, and tolerability between agomelatine and venlafaxine XR. Journal of Clinical Psychopharmacology 28, 329333.

RC Kessler , P Berglund , O Demler , R Jin , (2003). The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). Journal of the American Medical Association 289, 30953105.

A Khan , RM Leventhal , SR Khan , WA Brown (2002). Severity of depression and response to antidepressants and placebo: an analysis of the Food and Drug Administration database. Journal of Clinical Psychopharmacology 22, 4045.

E Lauterbach , W Felber , B Muller-Oerlinghausen , B Ahrens , (2008). Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: a randomised, placebo-controlled, 1-year trial. Acta Psychiatrica Scandinavica 118, 469479.

AC Leon (2007). The revised warning for antidepressants and suicidality: unveiling the black box of statistical analyses. American Journal of Psychiatry 164, 17861789.

AC Leon , DA Solomon , TI Mueller , J Endicott , (2003). A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness. American Journal of Psychiatry 160, 727733.

PJ McGrath , AY Khan , MH Trivedi , JW Stewart , (2008). Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report. Journal of Clinical Psychiatry 69, 18471855.

PJ McGrath , JW Stewart , M Fava , MH Trivedi , (2006). Tranylcypromine vs. venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. American Journal of Psychiatry 163, 15311541.

FJ McMahon , S Buervenich , D Charney , R Lipsky , (2006). Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. American Journal of Human Genetics 78, 804814.

AL Montejo , N Prieto , A Terleira , J Matias , (2010). Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale. Journal of Psychopharmacology 24, 111120.

RT Mulder , PR Joyce , CM Frampton , SE Luty , (2008). Antidepressant treatment is associated with a reduction in suicidal ideation and suicide attempts. Acta Psychiatrica Scandinavica 118, 116122.

A Nakagawa , MF Grunebaum , SP Ellis , MA Oquendo , (2007). Association of suicide and antidepressant prescription rates in Japan, 1999–2003. Journal of Clinical Psychiatry 68, 908916.

JC Nelson , GI Papakostas (2009). Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials. American Journal of Psychiatry 166, 980991.

AA Nierenberg , AH Farabaugh , JE Alpert , J Gordon , (2000). Timing of onset of antidepressant response with fluoxetine treatment. American Journal of Psychiatry 157, 14231428.

AA Nierenberg , JD Amsterdam (1990). Treatment-resistant depression: definition and treatment approaches. Journal of Clinical Psychiatry 51 (Suppl.), 3947.

AA Nierenberg , MM Husain , MH Trivedi , M Fava , (2010). Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report. Psychological Medicine 40, 4150.

AA Nierenberg , GI Papakostas , T Petersen , HD Montoya , (2003). Lithium augmentation of nortriptyline for subjects resistant to multiple antidepressants. Journal of Clinical Psychopharmacology 23, 9295.

GI Papakostas (2009). The role of S-adenosyl methionine in the treatment of depression. Journal of Clinical Psychiatry 70 (Suppl. 5), 1822.

GI Papakostas , CH Homberger , M Fava (2008). A meta-analysis of clinical trials comparing mirtazapine with selective serotonin reuptake inhibitors for the treatment of major depressive disorder. Journal of Psychopharmacology 22, 843848.

GI Papakostas , D Mischoulon , I Shyu , JE Alpert , (2010). S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. American Journal of Psychiatry 167, 942948.

GI Papakostas , RH Perlis , MJ Scalia , TJ Petersen , (2006). A meta-analysis of early sustained response rates between antidepressants and placebo for the treatment of major depressive disorder. Journal of Clinical Psychopharmacology 26, 5660.

GI Papakostas , T Peterson , KG Sklarsky , AA Nierenberg , (2007 b). Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder. Psychiatry Research 149, 195200.

GI Papakostas , ME Thase , M Fava , JC Nelson , (2007). Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents. Biological Psychiatry 62, 12171227.

RH Perlis , P Moorjani , J Fagerness , S Purcell , (2008). Pharmacogenetic analysis of genes implicated in rodent modesls of antidepressant response: association of TREK 1 and treatment resistance in the STAR(*)D study. Neuropsychopharmacology 33, 28102819.

RH Perlis , A Patrick , JW Smoller , PS Wang (2009). When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study. Neuropsychopharmacology 34, 22272236.

L Pintor , C Gasto , V Navarro , X Torres , (2003). Relapse of major depression after complete and partial remission during a 2-year follow-up. Journal of Affective Disorders 73, 237244.

NA Rasmussen , P Schroder , LR Olsen , M Brodsgaard , (2005). Modafinil augmentation in depressed patients with partial response to antidepressants: a pilot study on self-reported symptoms covered by the Major Depression Inventory (MDI) and the Symptoms Checklist (SCL-92). Nordic Journal of Psychiatry 59, 173178.

HG Ruhe , J Huyser , JA Swinkels , AH Schene (2006). Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review. Journal of Clinical Psychiatry 67, 18361855.

AJ Rush , MH Trivedi , SR Wisniewski , AA Nierenberg , (2006 a). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. American Journal of Psychiatry 163, 19051917.

AJ Rush , MH Trivedi , SR Wisniewski , JW Stewart , (2006 b). Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. New England Journal of Medicine 354, 12311242.

AJ Rush , SR Wisniewski , D Warden , JF Luther , (2008). Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment features. Archives of General Psychiatry 65, 870880.

G Sanacora (2009). Do glutamatergic agents represent a new class of antidepressant drugs? Part 1. Journal of Clinical Psychiatry 70, 14731474.

F Schindler , IG Anghelescu (2007). Lithium vs. lamotrigine augmentation in treatment resistant unipolar depression: a randomized, open-label study. International Clinical Psychopharmacology 22, 179182.

HB Simpson , JC Nee , J Endicott (1997). First-episode major depression: few sex differences in course. Archives of General Psychiatry 54, 633639.

DA Solomon , MB Keller , AC Leon , TI Mueller , (2000). Multiple recurrences of major depressive disorder. American Journal of Psychiatry 157, 229233.

SM Stahl , M Fava , MH Trivedi , A Caputo , (2010). Agomelatine in the treatment of major depressive disorder: an 8-week, multicenter, randomized, placebo-controlled trial. Journal of Clinical Psychiatry 71, 616626.

MH Trivedi , M Fava , SR Wisniewski , ME Thase (2006). Medication augmentation after the failure of SSRIs for depression. New England Journal of Medicine 354, 12431252.

M Versiani , R Moreno , CJ Ramakers-van Moorsel , AJ Schutte (2005). Comparative Efficacy Antidepressants Study Group. Comparison of the effects of mirtazapine and fluoxetine in severely depressed patients. CNS Drugs 19, 137146.

AG Wade , TE Schlaepfer , HF Andersen , CD Kilts (2009). Clinical milestones predict symptom remission over 6-month and choice of treatment of patients with major depressive disorder (MDD). Journal of Psychiatric Research 43, 568575.

KL Weihs , T Houser , SR Batey , JA Ascher , (2002). Continuation phase treatment with bupropion SR effectively decreases the risk for relapse of depression. Biological Psychiatry 51, 753761.

J Zajecka , A Schatzberg , S Stahl , A Shah , (2010). Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychopharmacology 30, 135144.

CA Zarate Jr, JB Singh , PJ Carlson , NE Brutsche , (2006 a). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry 63, 856864.

CA Zarate , JB Singh , JA Quiroz , G De Jesus , (2006 b). A double-blind, placebo-controlled study of memantine in the treatment of major depression. American Journal of Psychiatry 163, 153155.

M Zimmerman , MA Posternak , I Chelminski (2002). Symptom severity and exclusion from antidepressant efficacy trials. Journal of Clinical Psychopharmacology 22, 610614.

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