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  • The International Journal of Neuropsychopharmacology, Volume 16, Issue 9
  • October 2013, pp. 1927-1936

Can transcranial direct current stimulation enhance outcomes from cognitive training? A randomized controlled trial in healthy participants

  • Donel M. Martin (a1) (a2), Rose Liu (a2), Angelo Alonzo (a1) (a2), Melissa Green (a3), Michael J. Player (a1) (a2), Perminder Sachdev (a4) (a5) and Colleen K. Loo (a1) (a2) (a6)
  • DOI: http://dx.doi.org/10.1017/S1461145713000539
  • Published online: 30 May 2013
Abstract
Abstract

Computer-administered cognitive training (CT) tasks are a common component of cognitive remediation treatments. There is growing evidence that transcranial direct current stimulation (tDCS), when given during cognitive tasks, improves performance. This randomized, controlled trial explored the potential synergistic effects of CT combined with tDCS in healthy participants. Altogether, 60 healthy participants were randomized to receive either active or sham tDCS administered during training on an adaptive CT task (dual n-back task), or tDCS alone, over 10 daily sessions. Cognitive testing (working memory, processing speed, executive function, reaction time) was conducted at baseline, end of the 10 sessions, and at 4-wk follow-up to examine potential transfer effects to non-trained tasks. Altogether, 54 participants completed the study. Over the 10 ‘online’ sessions, participants in the active tDCS+CT condition performed more accurately on the CT task than participants who received sham tDCS+CT. The performance enhancing effect, however, was present only during tDCS and did not result in greater learning (i.e. improvement over sessions) on the CT task. These results confirm prior reports of enhancement of cognitive function during tDCS stimulation. At follow-up, the active tDCS+CT group, but not the sham tDCS+CT group, showed greater gains on a non-trained test of attention and working memory than the tDCS-only group (p < 0.01). Although this gain can mainly be attributable to training, this result suggests that active tDCS may have a role in further enhancing outcomes.

Copyright
Corresponding author
Address for correspondence: Professor C. Loo, Black Dog Institute, Prince of Wales Hospital, Barker St, Randwick. 2031, Australia. Tel.: 61 2 9382 3721Fax: 61 2 9382 8208Email: colleen.loo@unsw.edu.au
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AP Arul-Anandam , C Loo (2009) Transcranial direct current stimulation: a new tool for the treatment of depression? J Affect Disord 117:137145.

M Bikson , P Bulow , JW Stiller , A Datta , F Battaglia , SV Karnup , TT Postolache (2008) Transcranial direct current stimulation for major depression: a general system for quantifying transcranial electrotherapy dosage. Curr Treat Options Neurol 10:377385.

T Ditye , L Jacobson , V Walsh , M Lavidor (2012) Modulating behavioural inhibition by tDCS combined with cognitive training. Exp Brain Res 219:363368.

CA Dockery , D Liebetanz , N Birbaumer , M Malinowska , MJ Wesierska (2011) Cumulative benefits of frontal transcranial direct current stimulation on visuo-spatial working memory in rats. Neurobiol Learn Mem 96:452460.

A Flöel , W Suttorp , O Kohl , J Kürten , H Lohmann , C Breitenstein , S Knecht (2012) Non-invasive brain stimulation improves object-location learning in the elderly. Neurobiol Aging 33:16821689.

D Fox (2011) Brain buzz. Nature 472:156158.

F Fregni , PS Boggio , M Nitsche , F Bermpohl , A Antal , E Feredoes , MA Marcolin , SP Rigonatti , MTA Silva , W Paulus , A Pascual-Leone (2005) Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp Brain Res 166:2330.

J Fridriksson , JD Richardson , JM Baker , C Rorde (2011) Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a doubleblind, sham controlled study. Stroke 42:819821.

MB Iyer , U Mattu , J Grafman , M Lomarev , S Sato , EM Wassermann (2005) Safety and cognitive effect of frontal DC brain polarization in healthy individuals. Neurology 64:872875.

SM Jaeggi , M Buschkuehl , J Jonides , WJ Perrig (2008) Improving fluid intelligence with training on working memory. Proc Natl Acad Sci USA 105:68296833.

SM Jaeggi , B Studer-Luethi , M Buschkuehl , S Yi-Fen , J Jonides , WJ Perrig (2010) The relationship between n-back performance and matrix reasoning – implications for training and transfer. Intelligence 38:625635.

AH Javadi , V Walsh (2012) Transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex modulates declarative memory. Brain Stimul 5:231241.

T Klingsberg , H Forssberg , H Westerberg (2002) Training of working memory in children with ADHD. J Clin Exp Neuropsych 24:781791.

T Klingsberg , E Fernell , P Olesen , M Johnson , P Gustafsson , K Dahlström , CG Gillberg , H Forssberg , H Westerberg (2005) Computerized training of working memory in children with ADHD – a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 44:177186.

R Lindenberg , V Renga , LL Zhu , D Nair , G Schlaug (2010) Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients. Neurology 75:21762184.

C Loo , P Sachdev , D Martin , M Pigot , A Alonzo , GS Malhi , J Lagopoulos , P Mitchell (2010) A double-blind, sham controlled trial of transcranial direct current stimulation for the treatment of depression. Int J Neuropsychopharmacol 13:6169.

CK Loo , A Alonzo , D Martin , PB Mitchell , V Galvaz , P Sachdev (2012) A three-six week, randomized, sham-controlled trial of transcranial direct current stimulation in depression. Br J Psych 200:5259.

DM Martin , A Alonzo , PB Mitchell , P Sachdev , V Gálvez , CK Loo (2011) Fronto-extracephalic transcranial direct current stimulation as a treatment for major depression: an open-label pilot study. J Affect Disord 134:459463.

DM Martin , A Alonzo , K Ho , M Player , PB Mitchell , P Sachdev , CK Loo (2013) Continuation transcranial direct current stimulation for the prevention of relapse in major depression. J Affect Disord 144:274278.

V Moliadze , A Antal , Paulus (2010) Electrode-distance dependent after-effects of transcranial direct and random noise stimulation with extracephalic reference electrodes. Clin Neurophysiol 121:21652171.

MA Nitsche , W Paulus (2000) Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 527:633639.

MA Nitsche , W Paulus (2001) Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 57:18991901.

SH Ohn , CI Park , WK Yoo , MH Ko , KP Choi , GM Kim , YT Lee , Y Kim (2008) Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory. Neuroreport 19:4347.

RC Oldfield (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97113.

PJ Olesen , H Westerberg , T Klingberg (2004) Increased prefrontal and parietal activity after training of working memory. Nat Neurosci 7:7579.

J Reis , HM Schambra , LG Cohen , ER Buch , B Fritsch , E Zarahn , PA Celnik , JW Krakauer (2009) Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation. Proc Natl Acad Sci USA 106:15901595.

HM Schambra , M Abe , DA Luckenbaugh , J Reis , JW Krakauer , LG Cohen (2011) Probing for hemispheric specialisation for motor skill learning: a transcranial direct current stimulation study. J Neurophysiol 106:652661.

T Zaehle , P Sandmann , JD Thorne , L Jäncke , CS Herrmann (2011) Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence. BMC Neuro 12:2.

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  • EISSN: 1469-5111
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