Skip to main content
×
Home
    • Aa
    • Aa

Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers

  • Amira K. Brown (a1) (a2), Mark A. Mandelkern (a2) (a3), Judah Farahi (a2), Chelsea Robertson (a4), Dara G. Ghahremani (a1), Brittany Sumerel (a1), Nathasha Moallem (a1) and Edythe D. London (a1) (a4) (a5)...
Abstract
Abstract

In previous research, nicotine-dependent men exhibited lower putamen D2/D3 dopamine-receptor availability than non-smokers (Fehr et al.2008), but parallel assessments were not performed in women. Women and men (19 light smokers, 18 non-smokers) were tested for differences due to sex and smoking in striatal D2/D3 dopamine-receptor availability, using positron emission tomography with [18F]fallypride. Receptor availability was determined using a reference region method, in striatal volumes and in whole-brain, voxel-wise analysis. Significant sex×smoking interactions were observed in the caudate nuclei and putamen. Post-hoc t tests showed that male smokers had significantly lower D2/D3 dopamine-receptor availability than female smokers (−17% caudate, −21% putamen) and male non-smokers (−15% caudate, −16% putamen). Female smokers did not differ from non-smokers. Whole-brain analysis demonstrated no statistically significant voxels or clusters. These results suggest that low receptor availability may confer vulnerability to nicotine dependence or that smoking selectively affects D2/D3 receptor down-regulation in men but not women.

Copyright
Corresponding author
Address for correspondence: E. D. London, Ph.D., UCLA Semel Institute of Neuroscience and Biobehavioral Sciences, 760 Westwood Plaza, Rm. C8-831, Los Angeles, CA 90045, USA. Tel.: (310)825-0606Fax: 310-825-0812Email: elondon@mednet.ucla.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

BA Ardekani , S Ardekani , A Guckemus , MJ Bachman , (2005). Quantitative comparison of algorithms for inter-subject registration of 3D volumetric brain MRI scans. Journal of Neuroscience Methods 142, 6776.

BA Ardekani , M Braun , BF Hutton , I Kanno , (1995). A fully automatic multimodality image registration algorithm. Journal of Computer Assisted Tomography 19, 615623.

NL Benowitz , CN Lessov-Schlaggar , GE Swan , P Jacob 3rd (2006). Female sex and oral contraceptive use accelerate nicotine metabolism. Clinical Pharmacology & Therapeutics 79, 480488.

PW Czoty , NV Riddick , HD Gage , M Sandridge , (2009). Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys. Neuropsychopharmacology 34, 548554.

C Fehr , I Yakushev , N Hohmann , HG Buchholz , (2008). Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. American Journal of Psychiatry 165, 507514.

SB Harrod , CF Mactutus , K Bennett , U Hasselrot , (2004). Sex differences and repeated intravenous nicotine: behavioral sensitization and dopamine receptors. Pharmacology Biochemistry and Behavior 78, 581592.

HM Hudson , RS Larkin (1994). Accelerated image reconstruction using ordered subsets of projection data. IEEE Transactions on Medical Imaging 13, 601609.

TF Heatherton , LT Kozlowski , RC Frecker , KO Fagerstrom (1991). The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. British Journal of Addiction 86, 11191127.

M Jenkinson , PR Bannister , JM Brady , SM Smith (2002). Improved optimisation for the robust and accurate linear registration and motion correction of brain images. NeuroImage 17, 825841.

A Kobiella , S Vollstadt-Klein , M Buhler , C Graf , (2010). Human dopamine receptor D2/D3 availability predicts amygdala reactivity to unpleasant stimuli. Human Brain Mapping 31, 716726.

E Koylu , S Demirgoren , ED London , S Pogun (1997). Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain. Life Sciences 61, PL185PL190.

A Laakso , H Vilkman , J Bergman , M Haaparanta , (2002). Sex differences in striatal presynaptic dopamine synthesis capacity in healthy subjects. Biological Psychiatry 52, 759763.

AA Lammertsma , SP Hume (1996). Simplified reference tissue model for PET receptor studies. Neuroimage 4(3), 153158.

J Mukherjee , BT Christian , KA Dunigan , B Shi , (2002). Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors. Synapse 46, 170188.

J Mukherjee , ZY Yang , T Brown , R Lew , (1999). Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride. Nuclear Medicine and Biology 26, 519527.

D Paterson , A Nordberg (2000). Neuronal nicotinic receptors in the human brain. Progress in Neurobiology 61, 75111.

S Pogun , G Yararbas (2009). Sex differences in nicotine action. Handbook of Experimental Pharmacology 192, 261291.

P Riccardi , R Baldwin , R Salomon , S Anderson , (2008). Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride. Biological Psychiatry 63, 241244.

CD Spielberger , PR Vagg (1984). Psychometric properties of the STAI: a reply to Ramanaiah, Franzen, and Schill. Journal of Personality Assessment 48, 9597.

JK Staley , S Krishnan-Sarin , S Zoghbi , G Tamagnan , (2001). Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse 41, 275284.

RA Steer , R Ball , WF Ranieri , AT Beck (1999). Dimensions of the Beck Depression Inventory-II in clinically depressed outpatients. Journal of Clinical Psychology 55, 117128.

Y Wu , RE Carson (2002). Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging. Journal of Cerebral Blood Flow Metabolism 22, 14401452.

J Xu , A Azizian , J Monterosso , CP Domier , (2008). Gender effects on mood and cigarette craving during early abstinence and resumption of smoking. Nicotine and Tobacco Research 10, 16531661.

YK Yang , WJ Yao , TL Yeh , IH Lee , (2008). Decreased dopamine transporter availability in male smokers – a dual isotope SPECT study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32, 274279.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The International Journal of Neuropsychopharmacology
  • ISSN: 1461-1457
  • EISSN: 1469-5111
  • URL: /core/journals/the-international-journal-of-neuropsychopharmacology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
EXCEL
Supplementary Table

Brown Supplementary Table
Brown Supplementary Table

 Excel (25 KB)
25 KB