This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
SM Anderson , KR Famous , G Sadri-Vakili , V Kumaresan , (2008). CamkII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nature Neuroscience 11, 344–353.
JC Anthony , LA Warner , RC Kessler (1994). Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the national comorbidity survey. Experimental and Clinical Psychopharmacology 2, 244–268.
D Belin , E Balado , PV Piazza , V Deroche-Gamonet (2009). Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats. Biological Psychiatry 65, 863–868.
CR Bramham , MN Alme , M Bittins , SD Kuipers , (2010). The arc of synaptic memory. Experimental Brain Research 200, 125–140.
CR Bramham , PF Worley , MJ Moore , JF Guzowski (2008). The immediate early gene arc/arg3.1: regulation, mechanisms, and function. Journal of Neuroscience 28, 11760–11767.
B Caine , R Lintz , GF Koob (1992). Intravenous drug self-administration techniques in animals. In: A Sahgal (Ed.), Behavioural Neuroscience: A Practical Approach (pp. 117–143). Oxford: IRL Press.
SB Caine , GF Koob (1994). Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food. Journal of the Experimental Analysis of Behavior 61, 213–221.
D Centonze , B Picconi , P Gubellini , G Bernardi , (2001). Dopaminergic control of synaptic plasticity in the dorsal striatum. European Journal of Neuroscience 13, 1071–1077.
S Chowdhury , JD Shepherd , H Okuno , G Lyford , (2006). Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52, 445–459.
KL Conrad , KY Tseng , JL Uejima , JM Reimers , (2008). Formation of accumbens Glur2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454, 118–121.
A Contractor , SF Heinemann (2002). Glutamate receptor trafficking in synaptic plasticity. Science Signaling 2002, re14.
JW Dalley , TD Fryer , L Brichard , ES Robinson , (2007). Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315, 1267–1270.
V Deroche-Gamonet , D Belin , PV Piazza (2004). Evidence for addiction-like behavior in the rat. Science 305, 1014–1017.
DM Dietz , KC Dietz , EJ Nestler , SJ Russo (2009). Molecular mechanisms of psychostimulant-induced structural plasticity. Pharmacopsychiatry 42 (Suppl. 1), S69–S78.
BJ Everitt , TW Robbins (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nature Neuroscience 8, 1481–1489.
WM Freeman , ME Lull , KM Patel , RM Brucklacher , (2010). Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. BioMed Central Neuroscience 11, 1–13.
WM Freeman , KM Patel , RM Brucklacher , ME Lull , (2008). Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. Neuropsychopharmacology 33, 1807–1817.
Y Fu , S Pollandt , J Liu , B Krishnan , (2007). Long-term potentiation (LTP) in the central amygdala (CEA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors. Journal of Neurophysiology 97, 937–941.
M Graziella De Montis , C Co , SI Dworkin , JE Smith (1998). Modifications of dopamine D1 receptor complex in rats self-administering cocaine. European Journal of Pharmacology 362, 9–15.
JF Guzowski , GL Lyford , GD Stevenson , FP Houston , (2000). Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. Journal of Neuroscience 20, 3993–4001.
N Hay , N Sonenberg (2004). Upstream and downstream of mTOR. Genes & Development 18, 1926–1945.
MC Hearing , SW Miller , RE See , JF McGinty (2008 a). Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. Psychopharmacology 198, 77–91.
MC Hearing , RE See , JF McGinty (2008 b). Relapse to cocaine-seeking increases activity-regulated gene expression differentially in the striatum and cerebral cortex of rats following short or long periods of abstinence. Brain Structure and Function 213, 215–227.
CA Hoeffer , E Klann (2010). mTOR signaling: at the crossroads of plasticity, memory and disease. Trends in Neurosciences 33, 67–75.
SE Hyman (2005). Addiction: a disease of learning and memory. American Journal of Psychiatry 162, 1414–1422.
SE Hyman , RC Malenka , EJ Nestler (2006). Neural mechanisms of addiction: the role of reward-related learning and memory. Annual Reviews of Neuroscience 29, 565–598.
E Izzo , R Martin-Fardon , GF Koob , F Weiss , (2002). Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nature Neuroscience 5, 1263–1264.
PW Kalivas (2009). The glutamate homeostasis hypothesis of addiction. Nature Reviews Neuroscience 10, 561–572.
PW Kalivas , C O'Brien (2008). Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 33, 166–180.
F Kasanetz , V Deroche-Gamonet , N Berson , E Balado , (2010). Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science 328, 1709–1712.
S Kourrich , PE Rothwell , JR Klug , MJ Thomas (2007). Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens. Journal of Neuroscience 27, 7921–7928.
M Laplante , DM Sabatini (2009). mTOR signaling at a glance. Journal of Cell Science 122, 3589–3594.
C Luscher , KM Huber (2010). Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease. Neuron 65, 445–459.
P Luu , RC Malenka (2008). Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC. Journal of Neurophysiology 100, 533–538.
M Mameli , B Balland , R Lujan , C Luscher (2007). Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science 317, 530–533.
M Mameli , B Halbout , C Creton , D Engblom , (2009). Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAC. Nature Neuroscience 12, 1036–1041.
M Martin , BT Chen , FW Hopf , MS Bowers , (2006). Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nature Neuroscience 9, 868–869.
R Martin-Fardon , MA Baptista , CV Dayas , F Weiss (2009). Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer. Journal of Pharmacology and Experimental Therapeutics 329, 1084–1090.
D Martinez , A Broft , RW Foltin , M Slifstein , (2004). Cocaine dependence and D2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. Neuropsychopharmacology 29, 1190–1202.
RJ Moore , SL Vinsant , MA Nader , LJ Porrino , (1998). Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys. Synapse 30, 88–96.
K Moussawi , A Pacchioni , M Moran , MF Olive , (2009). N-acetylcysteine reverses cocaine-induced metaplasticity. Nature Neuroscience 12, 182–189.
MA Nader , JB Daunais , T Moore , SH Nader , (2002). Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology 27, 35–46.
M Narita , H Akai , T Kita , Y Nagumo , (2005). Involvement of mitogen-stimulated p70-s6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats. Neuroscience 132, 553–560.
G Page , FA Khidir , S Pain , L Barrier , (2006). Group I metabotropic glutamate receptors activate the p70s6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes. Neurochemistry International 49, 413–421.
RG Parsons , GM Gafford , FJ Helmstetter (2006). Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. Journal of Neuroscience 26, 12977–12983.
JK Penberthy , N Ait-Daoud , M Vaughan , T Fanning (2010). Review of treatment for cocaine dependence. Current Drug Abuse Reviews 3, 49–62.
RC Pierce , LJ Vanderschuren (2010). Kicking the habit: the neural basis of ingrained behaviors in cocaine addiction. Neuroscience Biobehavioral Reviews 35, 212–219.
LJ Porrino , D Lyons , HR Smith , JB Daunais , (2004). Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. Journal of Neuroscience 24, 3554–3562.
E Santini , M Heiman , P Greengard , E Valjent , (2009). Inhibition of mTOR signaling in parkinson's disease prevents L-dopa-induced dyskinesia. Science Signaling 2, ra36.
TD Schmittgen , KJ Livak (2008). Analyzing real-time PCR data by the comparative C(T) method. Nature Protocols 3, 1101–1108.
Y Serulle , S Zhang , I Ninan , D Puzzo , (2007). A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron 56, 670–688.
J Shi , W Jun , LY Zhao , YX Xue , (2009). Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts. European Journal of Pharmacology 615, 108–112.
L Slipczuk , P Bekinschtein , C Katche , M Cammarota , (2009). BDNF activates mTOR to regulate GluR1 expression required for memory formation. PLoS One 4, e6007.
MA Sutton , EF Schmidt , KH Choi , CA Schad , (2003). Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behavior. Nature 421, 70–75.
MA Ungless , JL Whistler , RC Malenka , A Bonci (2001). Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411, 583–587.
ND Volkow , JS Fowler , GJ Wang , R Hitzemann , (1993). Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 14, 169–177.
MW Waung , KM Huber (2009). Protein translation in synaptic plasticity: mGluRl-LTD, fragile X. Current Opinions in Neurobiology 19, 319–326.
F Weiss (2005). Neurobiology of craving, conditioned reward and relapse. Current Opinions in Pharmacology 5, 9–19.
ME Wolf , CR Ferrario (2010). AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine. Neuroscience Biobehavioral Reviews 35, 185–211.
AR Zavala , S Biswas , RE Harlan , JL Neisewander (2007). Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats. Neuroscience 145, 438–452.