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  • The International Journal of Neuropsychopharmacology, Volume 4, Issue 3
  • September 2001, pp. 265-268

Effect of electroconvulsive therapy in repetitive transcranial magnetic stimulation non-responder MDD patients: a preliminary study

  • Pinhas N. Dannon (a1) and Leon Grunhaus (a1)
  • DOI: http://dx.doi.org/10.1017/S1461145701002498
  • Published online: 01 September 2001
Abstract

The aim of this study was to measure the effectiveness of ECT in-patients who had failed to respond to a course of repetitive transcranial magnetic stimulation (rTMS) treatment. Seventeen patients with severe MDD who had not responded to a course of rTMS were switched to receive ECT treatments. All the patients were assessed with the Hamilton Rating Scale for Depression, the Global Assessment Functioning Scale, the Global Depression Scale, and the Pittsburgh Sleep Quality Index. Response to the treatment was defined as a 50% decrease in HDRS final score and a final GAS higher than 60. Seven out of 17 patients responded to ECT. Three out of 5 non-psychotics and 4 out of 12 psychotic patients responded. ECT seems to be an effective treatment for 40% of patients who failed to respond to rTMS treatment. Whether this is a result of reduced responsiveness to ECT in rTMS-resistant patients or a consequence of small sample size requires further study.

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Corresponding author
Address for correspondence: Dr P. N. Dannon, ECT-TMS Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. Tel.: +972-3-530332 Fax: +972-3-5353807 E-mail: dannon@attglobal.net
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The The International Journal of Neuropsychopharmacology
  • ISSN: 1461-1457
  • EISSN: 1469-5111
  • URL: /core/journals/the-international-journal-of-neuropsychopharmacology
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