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  • The International Journal of Neuropsychopharmacology, Volume 2, Issue 3
  • September 1999, pp. 193-195

Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive–compulsive disorder: a double-blind cross-over study

  • Mendel Fux (a1), Jonathan Benjamin (a2) and R. H. Belmaker (a1)
  • Published online: 01 September 1999

Current serotonin reuptake inhibitor (SRI) treatments for obsessive–compulsive disorder (OCD) provide only partial benefit. A previous study suggested that inositol alone is efficacious in OCD. Ten DSM-IV OCD patients completed a study of 18 g inositol or placebo for 6 wk each in addition to ongoing SRI treatment in a double-blind randomized cross-over design. Weekly assessments included the Yale–Brown Obsessive–Compulsive Scale (YBOCS) and Hamilton Depression and Anxiety scales. No significant difference was found between the two treatment phases.

Corresponding author
Address for correspondence: Dr Mendel Fux, Beer-Sheva, Mental Health Center, PO Box 4600, Beer-Sheva, Israel. Tel.: (972 7) 640-1602 Fax: (972 7) 640-1621 E-mail:
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The International Journal of Neuropsychopharmacology
  • ISSN: 1461-1457
  • EISSN: 1469-5111
  • URL: /core/journals/the-international-journal-of-neuropsychopharmacology
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