Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • The International Journal of Neuropsychopharmacology, Volume 8, Issue 4
  • December 2005, pp. 631-632

Lithium response and −116C/G polymorphism of XBP1 in Japanese patients with bipolar disorder

  • Chihiro Kakiuchi (a1) and Tadafumi Kato (a1)
  • DOI: http://dx.doi.org/10.1017/S146114570500533X
  • Published online: 01 April 2005
Abstract

Three mood stabilizers, lithium, valproate and carbamazepine, are known to be effective for a subset of patients with bipolar disorder, but the mechanism(s) of action for these three drugs is controversial (Gray et al., 2003). The response to treatment varies among individuals, but to date, no biological marker for predicting treatment response has been identified (Ikeda and Kato, 2003). Several groups have been pursuing a genetic marker that can be used to predict treatment response to lithium. Several polymorphisms of the genes such as serotonin transporter (Del Zompo et al., 1999; Serretti et al. 2001), tryptophan hydroxylase (Serretti et al., 1999) and inositol polyphosphate 1-phosphatase (Steen et al., 1998), have been suggested to relate to the lithium response, but these findings are still controversial. Thus, clinicians select mood stabilizers only empirically.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Lithium response and −116C/G polymorphism of XBP1 in Japanese patients with bipolar disorder
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Lithium response and −116C/G polymorphism of XBP1 in Japanese patients with bipolar disorder
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Lithium response and −116C/G polymorphism of XBP1 in Japanese patients with bipolar disorder
      Available formats
      ×
Copyright
Corresponding author
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2-1, Wako, Saitama, 351-0198, Japan. Tel.: +81-48-467-6949 Fax: +81-48-467-6947 E-mail: kato@brain.riken.jp
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The The International Journal of Neuropsychopharmacology
  • ISSN: 1461-1457
  • EISSN: 1469-5111
  • URL: /core/journals/the-international-journal-of-neuropsychopharmacology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×