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HM Abdolmaleky , K-H Cheng , SV Faraone , M Wilcox , SJ Glatt , F Gao , CL Smith , R Shafa , B Aeali , J Carnevale , H Pan , P Papageorgis , JF Ponte , V Sivaraman , MT Tsuang , S Thiagalingam (2006) Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet 15:3132–3145.
F Altieri , C Grillo , M Maceroni , S Chichiarelli (2008) DNA damage and repair: from molecular mechanisms to health implications. Antioxid Redox Signal 10:891–937.
AC Andreazza , BN Frey , B Erdtmann , M Salvador , F Rombaldi , A Santin , CA Gonçalves , F Kapczinski (2007) DNA damage in bipolar disorder. Psychiatry Res 153:27–32.
AC Andreazza , M Kauer-Sant'Anna , BN Frey , DJ Bond , F Kapczinski , LT Young , LN Yatham (2008) Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord 111:135–144.
M Berk (2009) Neuroprogression: pathways to progressive brain changes in bipolar disorder. Int J Neuropsychopharmacol 12:441–445.
M Berk , F Kapczinski , AC Andreazza , OM Dean , F Giorlando , M Maes , M Yücel , CS Gama , S Dodd , B Dean , PVS Magalhães , P Amminger , P McGorry , GS Malhi (2011) Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 35:804–817.
E Bora , M Yücel , C Pantelis (2010) Neurocognitive markers of psychosis in bipolar disorder: a meta-analytic study. J Affect Disord 127:1–9.
A Bromberg , Y Bersudsky , J Levine , G Agam (2009) Global leukocyte DNA methylation is not altered in euthymic bipolar patients. J Affect Disord 118:234–239.
N Buttner , S Bhattacharyya , J Walsh , FM Benes (2007) DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia. Schizophr Res 93:33–41.
RN Campos , LF Costa , DS Bio , MGS de Souza , CRL Garcia , FN Demétrio , DH Moreno , RA Moreno (2010) LICAVAL: combination therapy in acute and maintenance treatment of bipolar disorder. Trials 11:72.
JTO Cavanagh , M Van Beck , W Muir , DHR Blackwood (2002) Case–control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania. Br J Psychiatry 180:320–326.
Q Chen , A Fischer , JD Reagan , LJ Yan , BN Ames (1995) Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 92:4337–4341.
JY Choi , HS Kim , HK Kang , DW Lee , EM Choi , MH Chung (1999) Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radic Biol Med 27:848–854.
L Clark , SD Iversen , GM Goodwin (2002) Sustained attention deficit in bipolar disorder. Br J Psychiatry 180:313–319.
W Coryell , AC Leon , C Turvey , HS Akiskal , T Mueller , J Endicott (2001) The significance of psychotic features in manic episodes: a report from the NIMH collaborative study. J Affect Disord 67:79–88.
EL Dempster , R Pidsley , LC Schalkwyk , S Owens , A Georgiades , F Kane , S Kalidindi , M Picchioni , E Kravariti , T Toulopoulou , RM Murray , J Mill (2011) Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet 20:4786–4796.
SM El-Badri , CH Ashton , PB Moore , VR Marsh , IN Ferrier (2001) Electrophysiological and cognitive function in young euthymic patients with bipolar affective disorder. Bipolar Disord 3:79–87.
DL Evans (2005) Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry 58:175–189.
SA Everson-Rose , JS House , RP Mero (2004) Depressive symptoms and mortality risk in a national sample: confounding effects of health status. Psychosom Med 66:823–830.
IN Ferrier , JM Thompson (2002) Cognitive impairment in bipolar affective disorder: implications for the bipolar diathesis. Br J Psychiatry 180:293–295.
MJ Forlenza , GE Miller (2006) Increased serum levels of 8-hydroxy-2′-deoxyguanosine in clinical depression. Psychosom Med 68:1–7.
BB Gump , KA Matthews , LE Eberly , Y-F Chang , MRFIT Research Group (2005) Depressive symptoms and mortality in men: results from the Multiple Risk Factor Intervention Trial. Stroke 36:98–102.
JM Gutteridge , B Halliwell (2010) Antioxidants: molecules, medicines, and myths. Biochem Biophys Res Commun 393:561–564.
JU Guo , Y Su , C Zhong , G-L Ming , H Song (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145:423–434.
JM Gutteridge , B Halliwell (2000) Free radicals and antioxidants in the year 2000. A historical look to the future. Ann N Y Acad Sci 899:136–147.
R-P Juster , BS McEwen , SJ Lupien (2010) Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev 35:2–16.
F Kapczinski , E Vieta , AC Andreazza , BN Frey , FA Gomes , J Tramontina , M Kauer-Sant'Anna , R Grassi-Oliveira , RM Post (2008) Allostatic load in bipolar disorder: implications for pathophysiology and treatment. Neurosci Biobehav Rev 32:675–692.
M Kauer-Sant'Anna , F Kapczinski , AC Andreazza , DJ Bond , RW Lam , LT Young , LN Yatham (2009) Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. Int J Neuropsychopharmacol 12:447–458.
JE Klaunig , LM Kamendulis (2004) The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44:239–267.
A Klungland , I Rosewell , S Hollenbach , E Larsen , G Daly , B Epe , E Seeberg , T Lindahl , DE Barnes (1999) Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci USA 96:13300–13305.
R Kohen , A Nyska (2002) Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 30:620–650.
TB Kryston , AB Georgiev , P Pissis , AG Georgakilas (2011) Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 711:193–201.
DJ Kupfer (2005) The increasing medical burden in bipolar disorder. J Am Med Assoc 293:2528–2530.
N Kupper , Y Gidron , J Winter , J Denollet (2009) Association between type D personality, depression, and oxidative stress in patients with chronic heart failure. Psychosom Med 71:973–980.
G Kuratomi , K Iwamoto , M Bundo , I Kusumi , N Kato , N Iwata , N Ozaki , T Kato (2008) Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry 13:429–441.
G Lenaz (2001) The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 52:159–164.
S-O Lim , J-M Gu , MS Kim , H-S Kim , YN Park , CK Park , JW Cho , YM Park , G Jung (2008) Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 135:2128–2140.
IK Lyoo , YH Sung , SR Dager , SD Friedman , J-Y Lee , SJ Kim , N Kim , DL Dunner , PF Renshaw (2006) Regional cerebral cortical thinning in bipolar disorder. Bipolar Disord 8:65–74.
BS McEwen (2003) Interacting mediators of allostasis and allostatic load: towards an understanding of resilience in aging. Metab Clin Exp 52:10–16.
SA Montgomery , M Asberg (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389.
S Nohesara , M Ghadirivasfi , S Mostafavi , M-R Eskandari , H Ahmadkhaniha , S Thiagalingam , HM Abdolmaleky (2011) DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. J Psychiatr Res 45:1432–1438.
BW Penninx , JM Guralnik , M Pahor , L Ferrucci , JR Cerhan , RB Wallace , RJ Havlik (1998) Chronically depressed mood and cancer risk in older persons. J Natl Cancer Inst 90:1888–1893.
JM Plume , SRH Beach , GH Brody , RA Philibert (2012) A cross-platform genome-wide comparison of the relationship of promoter DNA methylation to gene expression. Front Genet 3:12.
Z Radak , I Boldogh (2010) 8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress. Free Radic Biol Med 49:587–596.
LJ Robinson , IN Ferrier (2006) Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence. Bipolar Disord 8:103–116.
A Rosa , MM Picchioni , S Kalidindi , CS Loat , J Knight , T Toulopoulou , R Vonk , AC van der Schot , W Nolen , RS Kahn , P McGuffin , RM Murray , IW Craig (2008) Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins. Am J Med Genet B Neuropsychiatr Genet 147B:459–462.
J Shen , P Deininger , JD Hunt , H Zhao (2007) 8-Hydroxy-2′-deoxyguanosine (8-OH-dG) as a potential survival biomarker in patients with nonsmall-cell lung cancer. Cancer 109:574–580.
A Spassky , D Angelov (1997) Influence of the local helical conformation on the guanine modifications generated from one-electron DNA oxidation. Biochemistry 36:6571–6576.
SM Strakowski , MP DelBello , ME Zimmerman , GE Getz , NP Mills , J Ret , P Shear , CM Adler (2002) Ventricular and periventricular structural volumes in first- vs. multiple-episode bipolar disorder. Am J Psychiatry 159:1841–1847.
AC Swann , CL Bowden , JR Calabrese , SC Dilsaver , DD Morris (2000) Mania: differential effects of previous depressive and manic episodes on response to treatment. Acta Psychiatr Scand 101:444–451.
AC Swann , CL Bowden , D Morris , JR Calabrese , F Petty , J Small , SC Dilsaver , JM Davis (1997) Depression during mania. Treatment response to lithium or divalproex. Arch Gen Psychiatry 54:37–42.
M Tahiliani , KP Koh , Y Shen , WA Pastor , H Bandukwala , Y Brudno , S Agarwal , LM Iyer , DR Liu , L Aravind , A Rao (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324:930–935.
M Tohen , CM Waternaux , MT Tsuang (1990) Outcome in mania. A 4-year prospective follow-up of 75 patients utilizing survival analysis. Arch Gen Psychiatry 47:1106–1111.
M Valko , M Izakovic , M Mazur , CJ Rhodes , J Telser (2004) Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266:37–56.
M Valko , CJ Rhodes , J Moncol , M Izakovic , M Mazur (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160:1–40.
JT Wachsman (1997) DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis. Mutat Res 375:1–8.
Y-C Wei , F-L Zhou , D-L He , J-R Bai , H Ding , X-Y Wang , K-J Nan (2009) Oxidative stress in depressive patients with gastric adenocarcinoma. Int J Neuropsychopharmacol 12:1089–1096.
ML Wood , M Dizdaroglu , E Gajewski , JM Essigmann (1990) Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 29:7024–7032.
RC Young , JT Biggs , VE Ziegler , DA Meyer (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429–435.