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  • The International Journal of Neuropsychopharmacology, Volume 12, Issue 9
  • October 2009, pp. 1275-1282

Pilot controlled trial of d-serine for the treatment of post-traumatic stress disorder

  • Uriel Heresco-Levy (a1) (a2), Agnes Vass (a1) (a2), Boaz Bloch (a3), Herman Wolosker (a4), Elena Dumin (a4), Livia Balan (a4), Lisa Deutsch (a1) and Ilana Kremer (a3)
  • DOI:
  • Published online: 15 April 2009

Enhancement of neurotransmission mediated at N-methyl-d-aspartate subtype of glutamate receptors (NMDAR) may be beneficial in post-traumatic stress disorder (PTSD). d-serine (DSR) is an endogenous full agonist at the NMDAR-associated glycine modulatory site. Twenty-two chronic PTSD outpatients were randomly assigned to participate in a 6-wk double-blind, placebo-controlled, crossover trial with 30 mg/kg.d DSR used as monotherapy or add-on pharmacotherapy. Outcome was assessed using the Clinician-Administered PTSD scale (CAPS), Hamilton Anxiety (HAMA) and Depression (HAMD) scales and the civilian version of the Mississippi Scale for Combat-Related PTSD (MISS). DSR treatment was well tolerated and resulted in significantly (p=0.03) increased DSR serum levels. Compared with placebo administration, DSR treatment resulted in significantly reduced HAMA (p=0.007) and MISS (p=0.001) scores and a trend (p=0.07) towards improved CAPS total scores. These preliminary findings indicate that NMDAR glycine site-based pharmacotherapy may be effective in PTSD and warrant larger-sized clinical trials with optimized DSR dosages.

Corresponding author
Address for correspondence: Professor U. Heresco-Levy, Ezrath Nashim-Herzog Memorial Hospital, PO Box 3900, Jerusalem, Israel91035. Tel.: 972-2-5316906Fax: 972-2-6536075Email:
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  • ISSN: 1461-1457
  • EISSN: 1469-5111
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