Skip to main content
×
Home
    • Aa
    • Aa
  • The International Journal of Neuropsychopharmacology, Volume 16, Issue 6
  • July 2013, pp. 1421-1425

The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients

  • Gavin P. Reynolds (a1), Olga O. Yevtushenko (a1), Sarah Gordon (a1), Belen Arranz (a2), Luis San (a3) and Stephen J. Cooper (a1)
  • DOI: http://dx.doi.org/10.1017/S1461145712001435
  • Published online: 14 December 2012
Abstract
Abstract

Genetic factors contribute to the individual variability in weight gain caused by several antipsychotic drugs. The FTO gene is associated with obesity in the general population; we have investigated whether a common risk polymorphism (rs9939609) in this gene is associated with antipsychotic drug-induced weight gain and obesity. Two samples were studied: (1) 93 first-episode patients receiving antipsychotic drugs for the first time and having body weight monitored for up to 12 months; (2) 187 chronic patients with schizophrenia assessed for measures of obesity and metabolic dysfunction. No association of FTO genotype with weight gain was found in initially drug-naive patients. The chronically treated patients had a significant association of genotype with body mass index (BMI), reflected in associations with waist circumference, waist:hip ratio and the frequency of central obesity. These findings indicate that FTO genotype has a major effect on body weight determined by BMI in chronically treated patients with schizophrenia.

Copyright
Corresponding author
Address for correspondence: Professor G. Reynolds, Biomedical Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK. Tel.: +44 114 3075Email:gavin.reynolds@shu.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

B Arranz , P Rosel , N Ramírez , R Dueñas , P Fernández , JM Sanchez , MA Navarro , L San (2004) Insulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients. J Clin Psychiatry 65:13351342.

MA De Hert , R van Winkel , D Van Eyck , L Hanssens , M Wampers , A Scheen , J Peuskens (2006) Prevalence of the metabolic syndrome in patients with schizophrenia treated with antipsychotic medication. Schizophr Res 83:8793.

KA Fawcett , I Barroso (2010) The genetics of obesity: FTO leads the way. Trends Genet 26:266274.

TM Frayling (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889894.

R Perez-Iglesias , I Mata , JA Amado , A Berja , MT Garcia-Unzueta , O Martínez García , MJ Arranz , JL Vazquez-Barquero , B Crespo-Facorro (2010) Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment. J Clin Psychopharmacol 30:661666.

GP Reynolds , SL Kirk (2010) Metabolic side effects of antipsychotic drug treatment-pharmacological mechanisms. Pharmacol Ther 125:169179.

MC Ryan , P Collins , JH Thakore (2003) Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. Aml J Psychiatry 160:284289.

LA Templeman , GP Reynolds , B Arranz , L San (2005) Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis. Pharmacogenet Genomics 15:195200.

P Wang , FJ Yang , H Du , YF Guan , TY Xu , XW Xu , DF Su , CY Miao (2011) Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med 17:523532.

OO Yevtushenko , SJ Cooper , R O'Neill , JK Doherty , JV Woodside , GP Reynolds (2008) Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia. Br J Psychiatry 192:424428.

ZJ Zhang , ZJ Yao , W Liu , Q Fang , GP Reynolds (2004) Effects of antipsychotics on fat deposition and changes in leptin and insulin levels. Magnetic resonance imaging study of previously untreated people with schizophrenia. Br J Psychiatry 184:5862.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The The International Journal of Neuropsychopharmacology
  • ISSN: 1461-1457
  • EISSN: 1469-5111
  • URL: /core/journals/the-international-journal-of-neuropsychopharmacology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: