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  • The International Journal of Neuropsychopharmacology, Volume 16, Issue 6
  • July 2013, pp. 1421-1425

The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients

  • Gavin P. Reynolds (a1), Olga O. Yevtushenko (a1), Sarah Gordon (a1), Belen Arranz (a2), Luis San (a3) and Stephen J. Cooper (a1)
  • DOI:
  • Published online: 14 December 2012

Genetic factors contribute to the individual variability in weight gain caused by several antipsychotic drugs. The FTO gene is associated with obesity in the general population; we have investigated whether a common risk polymorphism (rs9939609) in this gene is associated with antipsychotic drug-induced weight gain and obesity. Two samples were studied: (1) 93 first-episode patients receiving antipsychotic drugs for the first time and having body weight monitored for up to 12 months; (2) 187 chronic patients with schizophrenia assessed for measures of obesity and metabolic dysfunction. No association of FTO genotype with weight gain was found in initially drug-naive patients. The chronically treated patients had a significant association of genotype with body mass index (BMI), reflected in associations with waist circumference, waist:hip ratio and the frequency of central obesity. These findings indicate that FTO genotype has a major effect on body weight determined by BMI in chronically treated patients with schizophrenia.

Corresponding author
Address for correspondence: Professor G. Reynolds, Biomedical Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK. Tel.: +44 114
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The International Journal of Neuropsychopharmacology
  • ISSN: 1461-1457
  • EISSN: 1469-5111
  • URL: /core/journals/the-international-journal-of-neuropsychopharmacology
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