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Brain Activation During Response Interference in Twins Discordant or Concordant for Obsessive Compulsive Symptoms

  • Anouk den Braber (a1), Dennis van ‘t Ent (a1), Danielle C. Cath (a2), Dick J. Veltman (a3), Dorret I. Boomsma (a1) and Eco J. C. de Geus (a1)
  • DOI: http://dx.doi.org/10.1017/thg.2012.2
  • Published online: 15 June 2012
Abstract

One of the core behavioral features associated with obsessive compulsive symptomatology is the inability to inhibit thoughts and/or behaviors. Neuroimaging studies have indicated abnormalities in frontostriatal and dorsolateral prefrontal – anterior cingulate circuits during inhibitory control in patients with obsessive compulsive disorder compared with controls. In the present study, task performance and brain activation during Stroop color-word and Flanker interference were compared within monozygotic twin pairs discordant for obsessive compulsive symptoms and between groups of pairs scoring very low or very high on obsessive compulsive symptoms, in order to examine the differential impact of non-shared environmental versus genetic risk factors for obsessive compulsive symptomatology on inhibitory control related functional brain activation. Although performance was intact, brain activation during inhibition of distracting information differed between obsessive compulsive symptom high-scoring compared to low-scoring subjects. Regions affected in the discordant group (e.g., temporal and anterior cingulate gyrus) were partly different from those observed to be affected in the concordant groups (e.g., parietal gyrus and thalamus). A robust increase in dorsolateral prefrontal activity during response interference was observed in both the high-scoring twins of the discordant sample and the high-scoring twins of the concordant sample, marking this structure as a possible key region for disturbances in inhibitory control in obsessive compulsive disorder.

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Copyright
Corresponding author
address for correspondence: A. den Braber, Department of Biological Psychology, VU University, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. E-mail: a.den.braber@vu.nl
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U. Albert , G. Maina , F. Bogetto , & L. Ravizza (2000). The role of recent life events in the onset of obsessive-compulsive disorder. CNS Spectrums, 5, 4450.

P. Alonso , J. M. Menchon , D. Mataix-Cols , J. Pifarre , M. Urretavizcaya , J. M. Crespo , S. Jiménez , G. Vallejo , & J. Vallejo (2004). Perceived parental rearing style in obsessive-compulsive disorder: Relation to symptom dimensions. Psychiatry Research, 127, 267278.


D. C. Cath , D. S. van Grootheest , G. Willemsen , P. van Oppen , & D. I. Boomsma (2008). Environmental factors in obsessive-compulsive behavior: Evidence from discordant and concordant monozygotic twins. Behavior Genetics, 38, 108120.


E. J. de Geus , D. van ‘t Ent , S. P. Wolfensberger , P. Heutink , W. J. Hoogendijk , D. I. Boomsma , & D. J. Veltman (2007). Intrapair differences in hippocampal volume in monozygotic twins discordant for the risk for anxiety and depression. Biological Psychiatry, 61, 10621071.

A. den Braber , D. van ‘t Ent , D. I. Boomsma , D. C. Cath , D. J. Veltman , P. M. Thompson , & E. J. de Geus (2011). White matter differences in monozygotic twins discordant or concordant for obsessive-compulsive symptoms: A combined diffusion tensor imaging/voxel-based morphometry study. Biological Psychiatry, 70, 969977.

A. den Braber , D. van ‘t Ent , D. C. Cath , J. Wagner , D. I. Boomsma , & E. J. de Geus (2010). Brain activation during cognitive planning in twins discordant or concordant for obsessive-compulsive symptoms. Brain, 133, 31233140.

K. D. Fitzgerald , R. C. Welsh , W. J. Gehring , J. L. Abelson , J. A. Himle , I. Liberzon , & S. F. Taylor (2005). Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder. Biological Psychiatry, 57, 287294.

M. A. Fullana , D. Mataix-Cols , A. Caspi , H. Harrington , J. R. Grisham , T. E. Moffitt , & R. Poulton (2009). Obsessions and compulsions in the community: Prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions. American Journal of Psychiatry, 166, 329336.

H. J. Grabe , C. Meyer , U. Hapke , H. J. Rumpf , H. J. Freyberger , H. Dilling , & U. John (2000). Prevalence, quality of life and psychosocial function in obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany. European Archives of Psychiatry and Clinical Neuroscience, 250, 262268.

J. R. Grisham , T. M. Anderson , & P. S. Sachdev (2008). Genetic and environmental influences on obsessive-compulsive disorder. European Archives of Psychiatry and Clinical Neuroscience, 258, 107116.

J. M. Hettema , M. C. Neale , & K. S. Kendler (2001). A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry, 158, 15681578.

A. H. Jonnal , C. O. Gardner , C. A. Prescott , & K. S. Kendler (2000). Obsessive and compulsive symptoms in a general population sample of female twins. American Journal of Medical Genetics, 96, 791796.

J. G. Kerns , J. D. Cohen , A. W., III MacDonald , R. Y. Cho , V. A. Stenger , & C. S. Carter (2004). Anterior cingulate conflict monitoring and adjustments in control. Science, 303, 10231026.

H. Lin , L. Katsovich , M. Ghebremichael , D. B. Findley , H. Grantz , P. J. Lombroso , R. A. King , H. Zhang , & J. F. Leckman (2007). Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder. Journal of Child Psychology and Psychiatry, 48, 157166.

N. Maltby , D. F. Tolin , P. Worhunsky , T. M. O'Keefe , & K. A. Kiehl (2005). Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: An event-related fMRI study. Neuroimage, 24, 495503.

D. Mataix-Cols , & O. A. van den Heuvel (2006). Common and distinct neural correlates of obsessive-compulsive and related disorders. Psychiatric Clinics of North America, 29, 391410, viii.

T. Melcher , P. Falkai , & O. Gruber (2008). Functional brain abnormalities in psychiatric disorders: Neural mechanisms to detect and resolve cognitive conflict and interference. Brain Research Reviews, 59, 96124.

L. Menzies , S. Achard , S. R. Chamberlain , N. Fineberg , C. H. Chen , N. Del Campo , B. J. Sahakian , T. W. Robbins , & E. Bullmore (2007). Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain, 130, 32233236.

L. Menzies , S. R. Chamberlain , A. R. Laird , S. M. Thelen , B. J. Sahakian , & E. T. Bullmore (2008). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited. Neuroscience and Biobehavioral Reviews, 32, 525549.

T. Nakao , A. Nakagawa , T. Yoshiura , E. Nakatani , M. Nabeyama , H. Sanematsu , O. Togao , K. Yoshioka , M. Tomita , T. Kuroki , & S. Kanba (2009). Duration effect of obsessive-compulsive disorder on cognitive function: A functional MRI study. Depression and Anxiety, 26, 814823.

T. Nakao , A. Nakagawa , T. Yoshiura , E. Nakatani , M. Nabeyama , C. Yoshizato , A. Kudoh , K. Tada , K. Yoshioka , & M. Kawamoto (2005). A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task. Psychiatry Research, 139, 101114.

G. Nestadt , J. Samuels , M. Riddle , O. J. Bienvenu , K. Y. Liang III, M. LaBuda , J. Walkup , M. Grados , & R. Hoehn-Saric (2000). A family study of obsessive-compulsive disorder. Archives of General Psychiatry, 57, 358363.

H. Nicolini , P. Arnold , G. Nestadt , N. Lanzagorta , & J. L. Kennedy (2009). Overview of genetics and obsessive-compulsive disorder. Psychiatry Research, 170, 714.

L. A. Page , K. Rubia , Q. Deeley , E. Daly , F. Toal , D. Mataix-Cols , V. Giampietro , N. Schmitz , & D. G. Murphy (2009). A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorder. Psychiatry Research, 174, 202209.

J. Pujol , C. Soriano-Mas , P. Alonso , N. Cardoner , J. M. Menchon , J. Deus , & J. Vallejo (2004). Mapping structural brain alterations in obsessive-compulsive disorder. Archives of General Psychiatry, 61, 720–30.

S. Rachman , & P. de Silva (1978). Abnormal and normal obsessions. Behaviour Research and Therapy, 16, 233248.

J. Radua , & D. Mataix-Cols (2009). Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. British Journal of Psychiatry, 195, 393402.

J. Radua , O. A. van den Heuvel , S. Surguladze , & D. Mataix-Cols (2010). Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Archives of General Psychiatry, 67, 701711.

J. Y. Rotge , D. Guehl , B. Dilharreguy , J. Tignol , B. Bioulac , M. Allard , P. Burbaud , & B. Aouizerate (2009). Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biological Psychiatry, 65, 7583.

P. M. Salkovskis , & J. Harrison (1984). Abnormal and normal obsessions—a replication. Behavior Research and Therapy, 22, 549552.

S. Saxena , & S. L. Rauch (2000). Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatry Clinics of North America, 23, 563586.

R. G. Schlosser , G. Wagner , C. Schachtzabel , G. Peikert , K. Koch , J. R. Reichenbach , & H. Sauer (2010). Fronto-cingulate effective connectivity in obsessive compulsive disorder: A study with fMRI and dynamic causal modeling. Human Brain Mapping, 31, 18341850.

S. M. Sherman , & R. W. Guillery (2002). The role of the thalamus in the flow of information to the cortex. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences, 357, 16951708.

S. Ursu , V. A. Stenger , M. K. Shear , M. R. Jones , & C. S. Carter (2003). Overactive action monitoring in obsessive-compulsive disorder: Evidence from functional magnetic resonance imaging. Psychological Science, 14, 347353.

A. A., Jr. Valente , E. C. Miguel , C. C. Castro , E. Amaro , F. L. Duran Jr, C. A. Buchpiguel , X. Chitnis , P. K. McGuire , & G. F. Busatto (2005). Regional gray matter abnormalities in obsessive-compulsive disorder: A voxel-based morphometry study. Biological Psychiatry, 58, 479–87.

O. A. van den Heuvel , D. J. Veltman , H. J. Groenewegen , M. P. Witter , J. Merkelbach , D. C. Cath , A. J. van Balkom , P. van Oppen , & R. van Dyck (2005). Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Archives of General Psychiatry, 62, 922933.



P. van Oppen , R. J. Hoekstra , & P. M. Emmelkamp (1995). The structure of obsessive-compulsive symptoms. Behavior Research and Therapy, 33, 1523.

D. van ’t Ent , T. C. van Beijsterveldt , E. M. Derks , J. J. Hudziak , D. J. Veltman , R. D. Todd , D. I. Boomsma , & E. J. de Geus (2009). Neuroimaging of response interference in twins concordant or discordant for inattention and hyperactivity symptoms. Neuroscience, 164, 1629.


H. C. Wilcox , M. Grados , J. Samuels , M. A. Riddle , O. J. Bienvenu , A. Pinto III, B. Cullen , Y. Wang , Y. Y. Shugart , K. Y. Liang , & G. Nestadt (2008). The association between parental bonding and obsessive compulsive disorder in offspring at high familial risk. Journal of Affective Disorders, 111, 3139.

S. P. Wolfensberger , D. J. Veltman , W. J. Hoogendijk , D. I. Boomsma , & E. J. de Geus (2008). Amygdala responses to emotional faces in twins discordant or concordant for the risk for anxiety and depression. Neuroimage, 41, 544552.

M. Yucel , B. J. Harrison , S. J. Wood , A. Fornito , R. M. Wellard , J. Pujol , K. Clarke , M. L. Phillips , M. Kyrios , D. Velakoulis , & C. Pantelis (2007). Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Archives of General Psychiatry, 64, 946955.

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