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    von Wurmb-Schwark, Nicole Podruks, Elena Schwark, Thorsten Göpel, Wolfgang Fimmers, Rolf and Poetsch, Micaela 2015. About the power of biostatistics in sibling analysis—comparison of empirical and simulated data. International Journal of Legal Medicine, Vol. 129, Issue. 6, p. 1201.


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Causes of Delivery and Outcomes of Very Preterm Twins Stratified to Zygosity

  • Juliane Spiegler (a1), Christoph Härtel (a1), Lena Schulz (a1), Nicole von Wurmb-Schwark (a2), Thomas Hoehn (a3), Angela Kribs (a4), Helmut Küster (a5), Jens Siegel (a6), Christian Wieg (a7), Jan Weichert (a8), Egbert Herting (a1) and Wolfgang Göpel (a1)
  • DOI: http://dx.doi.org/10.1017/thg.2012.33
  • Published online: 05 July 2012
Abstract

The increasing rates of preterm birth among twins implicate that solid data on associated risks and outcomes are required. Assessment of zygosity is often based on clinical criteria (evaluation of placenta; same gender, birth weight discordance as surrogate criteria for monochorionic/monozygotic twins). The aim of this study was to compare clinical versus genetic assessment of zygosity and to compare causes of preterm delivery as well as outcome data of very-low-birth-weight (VLBW; birth weight <1,500 g) twins stratified to zygosity. In a multicenter study, we selected n = 176 sets of same gender twins and determined zygosity genetically. In a subgroup of 123 sets of twins, the attending physicians at the study centers were asked to document the parameter ‘zygosity’ (monozygotic/dizygotic) on the basis of their clinical judgment. Concordance between genetic and clinical assessment was 62.7% for monozygotic twins and 88.9% for dizygotic twins, respectively. Outcome parameters (death, BPD, ROP, NEC, IVH) were comparable in both groups. Genetically dizygotic twins were significantly more often born due to intrauterine infection (33% vs. 20% in monozygotic twins, p < .01) and antenatal antibiotics were more frequently given to mothers of dizygotic twins (62% vs. 47% in monozygotic twins, p < .01). Obstetric complications such as twin-twin-transfusion-syndrome were only seen in monozygotic twins as expected. The unexpected increase of antenatal antibiotic treatment and birth due to intrauterine infection in dizygotic twins should be confirmed in additional VLBW twin-cohorts.

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Corresponding author
address for correspondence: Dr. Juliane Spiegler, Department of Pediatrics, University Hospital of Schleswig-Holstein, Ratzeburger Allee 160, 23538 Luebeck, Germany. E-mail: uni@dr-spiegler.de
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Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
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