Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 7
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Reiter, L M Christensen, D L and Gjesing, A P 2016. Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review. Journal of Human Hypertension, Vol. 30, Issue. 8, p. 467.


    Basson, Jacob Simino, Jeannette and Rao, D. C. 2012. Between Candidate Genes and Whole Genomes: Time for Alternative Approaches in Blood Pressure Genetics. Current Hypertension Reports, Vol. 14, Issue. 1, p. 46.


    Sun, Ningling Xi, Yang Jing, Shan and Lu, Xining 2009. Morning blood pressure surge varies with age and gender in hypertensive individuals. International Journal of Cardiology, Vol. 135, Issue. 2, p. 272.


    Mottl, Amy K Shoham, David A and North, Kari E 2008. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Genetics in Medicine, Vol. 10, Issue. 8, p. 560.


    Nesbitt, Shawna D. 2008. Environmental, societal, and genetic contributions to the epidemic of hypertension in African Americans. Current Cardiovascular Risk Reports, Vol. 2, Issue. 3, p. 181.


    Binder, Alexander 2007. A review of the genetics of essential hypertension. Current Opinion in Cardiology, Vol. 22, Issue. 3, p. 176.


    Mathur, G. Cleland, J. G. F. Rodrigues, E. and Davis, G. K. 2007. Role of angiotensin receptor blockers in the prevention and management of ischaemic stroke. European Journal of Neurology, Vol. 14, Issue. 11, p. 1201.


    ×

Effects of Angiotensinogen and Angiotensin II Type I Receptor Genes on Blood Pressure and Left Ventricular Mass Trajectories in Multiethnic Youth

  • Xiaoling Wang (a1), Haidong Zhu (a2), Yanbin Dong (a3), Frank A. Treiber (a4) and Harold Snieder (a5)
  • DOI: http://dx.doi.org/10.1375/twin.9.3.393
  • Published online: 01 February 2012
Abstract
Abstract

The objective of this study was to evaluate the impact of variations of the angiotensinogen (AGT) and angiotensin II type I receptor (AGTR1) genes on progression of blood pressure (BP) and left ventricular mass (LVM) in multiethnic youth. The study was longitudinal involving 581 European American (EA) and African American (AA) youth with 12 assessments over a 15-year period. AGT M235T and three AGTR1 polymorphisms (C-521T, L191L and A1166C) were genotyped and individual growth curve modeling analyses were conducted. Single nucleotide polymorphism (SNP) analyses found a significant 3-way interaction between M235T, ethnicity and gender on BP levels. Systolic BP (SBP) levels were 5.8 mmHg (p = .00003) and diastolic BP (DBP) levels were 2.6 mmHg (p = .005) lower in carriers versus noncarriers of the M235 allele in AA males only. Furthermore, the AGTR1 L191 allele showed a SBP lowering effect in subjects with a high socioeconomic status (SES; p = .048) and a DBP lowering effect in AAs (p = .038). Haplotype analyses identified a protective haplotype (C-521, 191L and A1166) for LVM levels (p = .03). LVM in individuals homozygous for this haplotype was 12.9 g lower than those homozygous for the most common haplotype (–521T, 191L and A1166). No significant interactions were found between the AGT M235T polymorphism and any of the single SNPs or haplotypes of the AGTR1 gene. Our results in multiethnic youth uncover an ethnicity and gender-specific effect of the AGT M235T polymorphism and a SES or ethnicity-specific effect of the AGTR1 L191L polymorphism on the progression of hypertension risk. A protective AGTR1 haplotype for LVM was also identified.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effects of Angiotensinogen and Angiotensin II Type I Receptor Genes on Blood Pressure and Left Ventricular Mass Trajectories in Multiethnic Youth
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effects of Angiotensinogen and Angiotensin II Type I Receptor Genes on Blood Pressure and Left Ventricular Mass Trajectories in Multiethnic Youth
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effects of Angiotensinogen and Angiotensin II Type I Receptor Genes on Blood Pressure and Left Ventricular Mass Trajectories in Multiethnic Youth
      Available formats
      ×
Copyright
Corresponding author
*Address for correspondence: Dr. Harold Snieder, Georgia Prevention Institute, Medical College of Georgia, Building HS-1640, Augusta, GA 30912, USA.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×