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Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

  • Hamdi Mbarek (a1), Yuri Milaneschi (a2), Jouke-Jan Hottenga (a1), Lannie Ligthart (a1), Eco J. C. de Geus (a1), Erik A. Ehli (a3), Gonneke Willemsen (a1), Gareth E. Davies (a3), Jan H. Smit (a2), Dorret I. Boomsma (a1) and Brenda W. J. H. Penninx (a2)...
Abstract

In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10−8) and gene-based (p = 1.48 × 10−7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.

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Copyright
Corresponding author
Address for correspondence: Hamdi Mbarek, Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, the Netherlands. E-mail: h.mbarek@vu.nl/y.milanechi@ggzingeest.nl
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a

These authors contributed equally to this work.

b

These authors contributed equally to this work.

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References
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Ahmed, M. Y., Chioza, B. A., Rajab, A., Schmitz-Abe, K., Al-Khayat, A., Al-Turki, S., . . . Mochida, G. H. (2015). Loss of PCLO function underlies pontocerebellar hypoplasia type III. Neurology, 84, 17451750.
Boomsma, D. I., Beem, A. L., van den Berg, M., Dolan, C. V., Koopmans, J. R., Vink, J. M., . . . Slagboom, P. E. (2000). Netherlands twin family study of anxious depression (NETSAD). Twin Research, 3, 323334.
Boomsma, D. I., Willemsen, G., Sullivan, P. F., Heutink, P., Meijer, P., Sondervan, D., . . . Penninx, B. W. (2008). Genome-wide association of major depression: Description of samples for the GAIN major depressive disorder study: NTR and NESDA biobank projects. European Journal of Human Genetics, 16, 335342.
Hek, K., Mulder, C. L., Luijendijk, H. J., van Duijn, C. M., Hofman, A., Uitterlinden, A. G., & Tiemeier, H. (2010). The PCLO gene and depressive disorders: Replication in a population-based study. Human Molecular Genetics, 19, 731734.
Hyde, C. L., Nagle, M. W., Tian, C., Chen, X., Paciga, S. A., Wendland, J. R., . . . Winslow, A. R. (2016). Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nature Genetics, 48, 10311036.
Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., Perlis, R. H., . . . Wray, N. R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45, 984994.
Okbay, A., Baselmans, B. M., De Neve, J. E., Turley, P., Nivard, M. G., Fontana, M. A., . . . Cesarini, D. (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48, 624633.
Sullivan, P. F., de Geus, E. J., Willemsen, G., James, M. R., Smit, J. H., Zandbelt, T., . . . Penninx, B. W. (2009). Genome-wide association for major depressive disorder: A possible role for the presynaptic protein piccolo. Molecular Psychiatry, 14, 359375.
Verbeek, E. C., Bevova, M. R., Bochdanovits, Z., Rizzu, P., Bakker, I. M., Uithuisje, T., . . . Heutink, P. (2013). Resequencing three candidate genes for major depressive disorder in a Dutch cohort. PLoS One, 8, e79921.
Waites, C. L., Leal-Ortiz, S. A., Andlauer, T. F., Sigrist, S. J., & Garner, C. C. (2011). Piccolo regulates the dynamic assembly of presynaptic F-actin. Journal of Neuroscience, 31, 1425014263.
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Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
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