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Heritability of Cortisol Regulation in Children

  • Per A. Gustafsson (a1), Per E. Gustafsson (a2), Henrik Anckarsäter (a3), Paul Lichtenstein (a4), Therese Ljung (a4), Nina Nelson (a5) and Henrik Larsson (a4)...
Abstract

Background: The normal development of cortisol regulation during childhood is thought to be influenced by a complex interplay between environmental and genetic factors. Method: The aim of this study was to estimate genetic and environmental influences on basal cortisol levels in a sample of 151 twin pairs aged 9–16 years. Salivary cortisol was collected on two consecutive days when the children attended school — immediately after awakening, 30 min post-awakening and at bedtime. Results: Heritability was highest (60%) for cortisol levels about 30 min after awakening. For samples taken immediately at awakening heritability was less pronounced (28%) and in the evening low (8%). Conclusion: The limited genetic influence on evening levels, moderate on cortisol at awakening and high on awakening response, might imply two genetic regulation patterns, one specifically for awakening response and one for the circadian rhythm proper. These findings could explain divergent results in previous studies and highlight the importance of taking the circadian rhythm into account in studies of cortisol levels in children.

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Corresponding author
ADDRESS FOR CORRESPONDENCE: Per A. Gustafsson, Dept of Clinical and Experimental Medicine, Child and Adolescent Psychiatry, Linköping University, S-581 95 Linköping, Sweden. E-mail: Per.A.Gustafsson@liu.se
References
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Anckarsäter, H., Lundström, S., Kollberg, L., Kerekes, N., Palm, C., Carlström, E., Långström, N., Magnusson, P., Halldner, L., Bölte, S., Gillberg, C., Gumpert, C., Råstam, M., & Lichtenstein, P. (2011). The Child and Adolescent Twin Study in Sweden (CATSS). Twin Research and Human Genetics, 14, 495508.
Bartels, M., de Geus, E. J., Kirschbaum, C., Sluyter, F., & Boomsma, D. I. (2003a). Heritability of daytime cortisol levels in children. Behavior Genetics, 33, 421433.
Bartels, M., Van den Berg, M., Sluyter, F., Boomsma, D. I., & de Geus, E. J. (2003b). Heritability of cortisol levels: Review and simultaneous analysis of twin studies. Psychoneuroendocrinology, 28, 121137.
Broderick, J. E., Arnold, D., Kudielka, B. M., & Kirschbaum, C. (2004). Salivary cortisol sampling compliance: Comparison of patients and healthy volunteers. Psychoneuroendocrinology, 29, 636650.
Bruehl, H., Wolf, O. T., & Convit, A. (2009). A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes mellitus. Psychoneuroendocrinology, 34, 815821.
Buchanan, T. W., Kern, S., Allen, J. S., Tranel, D., & Kirschbaum, C. (2004). Circadian regulation of cortisol after hippocampal damage in humans. Biological Psychiatry, 56, 651656.
Chida, Y., & Steptoe, A. (2009). Cortisol awakening response and psychosocial factors: A systematic review and metaanalysis. Biological Psychology, 80, 265278.
Clow, A., Hucklebridge, F., Stalder, T., Evans, P., & Thorn, L. (2010). The cortisol awakening response: More than a measure of HPA axis function. Neuroscience and Biobehavioral Reviews, 35, 97103.
Dekker, M. J., Koper, J. W., van Aken, M. O., Pols, H. A., Hofman, A., de Jong, F. H., Kirschbaum, C., Witteman, J.C., Lamberts, S.W., & Tiemeier, H. (2008). Salivary cortisol is related to atherosclerosis of carotid arteries. The Journal of Clinical Endocrinology and Metabolism, 93, 37413747.
Delahanty, D. L., Nugent, N. R., Christopher, N. C., & Walsh, M. (2005). Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims. Psychoneuroendocrinology, 30, 121128.
DeRijk, R. H., Wust, S., Meijer, O. C., Zennaro, M. C., Federenko, I. S., Hellhammer, D. H., Giacchetti, G., Vreugdenhil, E., Zitman, F.G., & de Kloet, E.R. (2006). A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. The Journal of Clinical Endocrinology and Metabolism, 91, 50835089.
Dockray, S., Bhattacharyya, M. R., Molloy, G. J., & Steptoe, A. (2008). The cortisol awakening response in relation to objective and subjective measures of waking in the morning. Psychoneuroendocrinology, 33, 7782.
Edwards, S., Clow, A., Evans, P., & Hucklebridge, F. (2001). Exploration of the awakening cortisol response in relation to diurnal cortisol secretory activity. Life Sciences, 68, 20932103.
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009). The cortisol awakening response (CAR): Facts and future directions. International Journal of Psychophysiology, 72, 6773.
Goodyer, I. M., Park, R. J., & Herbert, J. (2001). Psychosocial and endocrine features of chronic first-episode major depression in 8–16 year olds. Biological Psychiatry, 50, 351357.
Groschl, M., Rauh, M., & Dorr, H. G. (2003). Circadian rhythm of salivary cortisol, 17alpha-hydroxyprogesterone, and progesterone in healthy children. Clinical Chemistry, 49, 16881691.
Gunnar, M., & Quevedo, K. (2007). The neurobiology of stress and development. Annual review of psychology, 58, 145173.
Gustafsson, P. E., Anckarsater, H., Lichtenstein, P., Nelson, N., & Gustafsson, P. A. (2010a). Does quantity have a quality all its own? Cumulative adversity and up- and down-regulation of circadian salivary cortisol levels in healthy children. Psychoneuroendocrinology, 35, 14101415.
Gustafsson, P. E., Gustafsson, P. A., & Nelson, N. (2006). Cortisol levels and psychosocial factors in preadolescent children. Stress and Health, 22, 39.
Gustafsson, P. E., Janlert, U., Theorell, T., & Hammarstrom, A. (2010b). Life-course socioeconomic trajectories and diurnal cortisol regulation in adulthood. Psychoneuroendocrinology, 35, 613623.
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W.E. (2003). Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Frontiers in Neuroendocrinology, 24, 151180.
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005). Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis. Progress in neuro-psychopharmacology & biological psychiatry, 29, 12011213.
Jefferies, C. A., Hofman, P. L., Wong, W., Robinson, E. M., & Cutfield, W. S.. (2003). Increased nocturnal blood pressure in healthy prepubertal twins. Journal of Hypertension 21, 13191324.
Kiess, W., Meidert, A., Dressendorfer, R. A., Schriever, K., Kessler, U., Konig, A., Schwarz, H.P., Strasburger, C.J. (1995). Salivary cortisol levels throughout childhood and adolescence: Relation with age, pubertal stage, and weight. Pediatric Research, 37, 502506.
King, J. A., Barkley, R. A., & Barrett, S. (1998). Attention-deficit hyperactivity disorder and the stress response. Biological psychiatry, 44, 7274.
Knutsson, U., Dahlgren, J., Marcus, C., Rosberg, S., Bronnegard, M., Stierna, P., & Albertsson-Wikland, K. (1997). Circadian cortisol rhythms in healthy boys and girls: Relationship with age, growth, body composition, and pubertal development. Journal of Clinical Endocrinology & Metabolism, 82, 536540.
Kudielka, B. M., Broderick, J. E., & Kirschbaum, C. (2003). Compliance with saliva sampling protocols: Electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjects. Psychosomatic medicine, 65, 313319.
Kupper, N., de Geus, E. J., van den Berg, M., Kirschbaum, C., Boomsma, D. I., & Willemsen, G. (2005). Familial influences on basal salivary cortisol in an adult population. Psychoneuroendocrinology, 30, 857868.
Larson, T., Anckarsater, H., Gillberg, C., Stahlberg, O., Carlstrom, E., Kadesjo, B., Råstam, M., Lichtenstein, P., Gillberg, Ch. (2010). The autism–tics, AD/HD and other comorbidities inventory (A-TAC): Further validation of a telephone interview for epidemiological research. BMC Psychiatry, 10, 1.
Lupien, S. J., King, S., Meaney, M. J., & McEwen, B. S. (2000). Child's stress hormone levels correlate with mother's socioeconomic status and depressive state. Biological Psychiatry, 48, 976980.
Matthews, K., Schwartz, J., Cohen, S., & Seeman, T. (2006). Diurnal cortisol decline is related to coronary calcification: CARDIA study. Psychosomatic Medicine, 68, 657661.
McBurnett, K., Lahey, B. B., Rathouz, P. J., & Loeber, R. (2000). Low salivary cortisol and persistent aggression in boys referred for disruptive behavior. Archives of General Psychiatry, 57, 3843.
Miller, G. E., Chen, E., & Zhou, E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychological Bulletin, 133, 2545.
Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx: statistical modeling. Richmond: Department of Psychiatry.
Netherton, C., Goodyer, I., Tamplin, A., & Herbert, J. (2004). Salivary cortisol and dehydroepiandrosterone in relation to puberty and gender. Psychoneuroendocrinology, 29, 125140.
Oskis, A., Loveday, C., Hucklebridge, F., Thorn, L., & Clow, A. (2009). Diurnal patterns of salivary cortisol across the adolescent period in healthy females. Psychoneuroendocrinology, 34, 307316.
Ouellet-Morin, I., Dionne, G., Perusse, D., Lupien, S. J., Arseneault, L., Barr, R. G., Tremblay, R.E., & Boivin, M. (2009). Daytime cortisol secretion in 6-month-old twins: genetic and environmental contributions as a function of early familial adversity. Biological Psychiatry, 65, 409416.
Pfeffer, C. R., Altemus, M., Heo, M., & Jiang, H. (2007). Salivary cortisol and psychopathology in children bereaved by the september 11, 2001 terror attacks. Biological psychiatry, 61, 957965.
Plomin, R., DeFries, J., McClearn, G. E., & McGuffin, P. (2001). Behavioral genetics. New York: Worth Publishers.
Pruessner, J. C., Wolf, O. T., Hellhammer, D. H., Buske-Kirschbaum, A., von Auer, K., Jobst, S., Kaspers, F., & Kirschbaum, C. (1997). Free cortisol levels after awakening: A reliable biological marker for the assessment of adrenocortical activity. Life sciences, 61(26), 25392549.
Pruessner, M., Pruessner, J. C., Hellhammer, D. H., Bruce Pike, G., & Lupien, S. J. (2007). The associations among hippocampal volume, cortisol reactivity, and memory performance in healthy young men. Psychiatry Research, 155, 110.
Rosmalen, J. G., Oldehinkel, A. J., Ormel, J., de Winter, A. F., Buitelaar, J. K., & Verhulst, F. C. (2005). Determinants of salivary cortisol levels in 10–12 year old children: A population-based study of individual differences. Psychoneuroendocrinology, 30, 483495.
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews, 21, 5589.
Schreiber, J. E., Shirtcliff, E., Van Hulle, C., Lemery-Chalfant, K., Klein, M. H., Kalin, N. H., Essex, M. J., & Goldsmith, H. H. (2006). Environmental influences on family similarity in afternoon cortisol levels: Twin and parent-offspring designs. Psychoneuroendocrinology, 31, 11311137.
Sorrells, S. F., & Sapolsky, R. M. (2007). An inflammatory review of glucocorticoid actions in the CNS. Brain, Behavior, and Immunity, 21), 259272.
Steptoe, A., van Jaarsveld, C. H., Semmler, C., Plomin, R., & Wardle, J. (2009). Heritability of daytime cortisol levels and cortisol reactivity in children. Psychoneuroendocrinology, 34, 273280.
Wilhelm, I., Born, J., Kudielka, B. M., Schlotz, W., & Wust, S. (2007). Is the cortisol awakening rise a response to awakening? Psychoneuroendocrinology, 32, 358366.
Wright, C. E., & Steptoe, A. (2005). Subjective socioeconomic position, gender and cortisol responses to waking in an elderly population. Psychoneuroendocrinology, 30, 582590.
Wüst, S., Federenko, I., Hellhammer, D. H., & Kirschbaum, C. (2000a). Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology, 25, 707720.
Wüst, S., Wolf, J., Hellhammer, D. H., Federenko, I., Schommer, N., & Kirschbaum, C. (2000b). The cortisol awakening response — normal values and confounds. Noise Health, 2, 7988.
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