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IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies

  • Nancy L. Pedersen (a1) (a2), Kaare Christensen (a3), Anna K. Dahl (a1) (a4), Deborah Finkel (a5), Carol E. Franz (a6), Margaret Gatz (a1) (a2), Briana N. Horwitz (a7), Boo Johansson (a8), Wendy Johnson (a9), William S. Kremen (a6) (a10), Michael J. Lyons (a11), Bo Malmberg (a4), Matt McGue (a3) (a12), Jenae M. Neiderhiser (a7), Inge Petersen (a3) and Chandra A. Reynolds (a13)
  • DOI:
  • Published online: 28 November 2012

The Interplay of Genes and Environment across Multiple Studies (IGEMS) group is a consortium of eight longitudinal twin studies established to explore the nature of social context effects and gene-environment interplay in late-life functioning. The resulting analysis of the combined data from over 17,500 participants aged 25–102 at baseline (including nearly 2,600 monogygotic and 4,300 dizygotic twin pairs and over 1,700 family members) aims to understand why early life adversity, and social factors such as isolation and loneliness, are associated with diverse outcomes including mortality, physical functioning (health, functional ability), and psychological functioning (well-being, cognition), particularly in later life.

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Corresponding author
address for correspondence: Nancy L. Pedersen, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden. E-mail:
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Twin Research and Human Genetics
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