Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 6
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Qi, Q. Cavanagh, M. M. Le Saux, S. NamKoong, H. Kim, C. Turgano, E. Liu, Y. Wang, C. Mackey, S. Swan, G. E. Dekker, C. L. Olshen, R. A. Boyd, S. D. Weyand, C. M. Tian, L. and Goronzy, J. J. 2016. Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination. Science Translational Medicine, Vol. 8, Issue. 332, p. 332ra46.


    Rubelt, Florian Bolen, Christopher R. McGuire, Helen M. Heiden, Jason A. Vander Gadala-Maria, Daniel Levin, Mikhail M. Euskirchen, Ghia Mamedov, Murad R. Swan, Gary E. Dekker, Cornelia L. Cowell, Lindsay G. Kleinstein, Steven H. and Davis, Mark M. 2016. Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells. Nature Communications, Vol. 7, p. 11112.


    Brodin, Petter Jojic, Vladimir Gao, Tianxiang Bhattacharya, Sanchita Angel, Cesar J. Lopez Furman, David Shen-Orr, Shai Dekker, Cornelia L. Swan, Gary E. Butte, Atul J. Maecker, Holden T. and Davis, Mark M. 2015. Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences. Cell, Vol. 160, Issue. 1-2, p. 37.


    Wang, Chen Liu, Yi Cavanagh, Mary M. Le Saux, Sabine Qi, Qian Roskin, Krishna M. Looney, Timothy J. Lee, Ji-Yeun Dixit, Vaishali Dekker, Cornelia L. Swan, Gary E. Goronzy, Jörg J. and Boyd, Scott D. 2015. B-cell repertoire responses to varicella-zoster vaccination in human identical twins. Proceedings of the National Academy of Sciences, Vol. 112, Issue. 2, p. 500.


    Dominguez-Salas, Paula Moore, Sophie E. Baker, Maria S. Bergen, Andrew W. Cox, Sharon E. Dyer, Roger A. Fulford, Anthony J. Guan, Yongtao Laritsky, Eleonora Silver, Matt J. Swan, Gary E. Zeisel, Steven H. Innis, Sheila M. Waterland, Robert A. Prentice, Andrew M. and Hennig, Branwen J. 2014. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications, Vol. 5,


    Horowitz, A. Strauss-Albee, D. M. Leipold, M. Kubo, J. Nemat-Gorgani, N. Dogan, O. C. Dekker, C. L. Mackey, S. Maecker, H. Swan, G. E. Davis, M. M. Norman, P. J. Guethlein, L. A. Desai, M. Parham, P. and Blish, C. A. 2013. Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry. Science Translational Medicine, Vol. 5, Issue. 208, p. 208ra145.


    ×

The Twin Research Registry at SRI International

  • Ruth E. Krasnow (a1), Lisa M. Jack (a1), Christina N. Lessov-Schlaggar (a2), Andrew W. Bergen (a1) and Gary E. Swan (a1)
  • DOI: http://dx.doi.org/10.1017/thg.2012.81
  • Published online: 19 October 2012
Abstract

The Twin Research Registry (TRR) at SRI International is a community-based registry of twins established in 1995 by advertising in local media, mainly on radio stations and in newspapers. As of August 2012, there are 3,120 same- and opposite-sex twins enrolled; 86% are 18 years of age or older (mean age 44.9 years, SD 16.9 years) and 14% less than 18 years of age (mean age 8.9 years, SD 4.5); 67% are female, and 62% are self-reported monozygotic (MZ). More than 1,375 twins have participated in studies over the last 15 years in collaboration with the University of California Medical Center in San Francisco, the University of Texas MD Anderson Cancer Center, and the Stanford University School of Medicine. Each twin completes a registration form with basic demographic information either online at the TRR Web site or during a telephone interview. Contact is maintained with members by means of annual newsletters and birthday cards. The managers of the TRR protect the confidentiality of twin data with established policies; no information is given to other researchers without prior permission from the twins; and all methods and procedures are reviewed by an Institutional Review Board. Phenotypes studied thus far include those related to nicotine metabolism, mutagen sensitivity, pain response before and after administration of an opioid, and a variety of immunological responses to environmental exposures, including second-hand smoke and vaccination for seasonal influenza virus and Varicella zoster virus. Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The Twin Research Registry at SRI International
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      The Twin Research Registry at SRI International
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      The Twin Research Registry at SRI International
      Available formats
      ×
Copyright
Corresponding author
address for correspondence: Gary E. Swan, PhD, Center for Health Sciences, SRI International, 333 Ravenswood, BN133, Menlo Park, CA 94025, USA. E-mail: gary.swan@sri.com
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

N. Al Koudsi , J. C. Mwenifumbo , E. M. Sellers , N. L. Benowitz , G. E. Swan , & R. F. Tyndale (2006). Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics. European Journal of Clinical Pharmacology, 62, 481484.

M. S. Angst , L. C. Lazzeroni , N. G. Phillips , D. R. Drover , M. Tingle , A. Ray , . . . J. D. Clark (2012). Aversive and reinforcing opioid effects: A pharmacogenomic twin study. Anesthesiology, 117, 2237.

M. S. Angst , N. G. Phillips , D. R. Drover , M. Tingle , A. Ray , G. E. Swan , . . . J. D. Clark (2012). Pain sensitivity and opioid analgesia: A pharmacogenomic twin study. Pain, 153, 13971409.

J. T. Bell , & T. D. Spector (2011). A twin approach to unraveling epigenetics. Trends In Genetics, 27, 116125.

N. L. Benowitz , & Jacob, P. 3rd. (1994). Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clinical Pharmacology and Therapeutics, 56, 483493.

N. L. Benowitz , C. N. Lessov-Schlaggar , & G. E. Swan (2008). Genetic influences in the variation in renal clearance of nicotine and cotinine. Clinical Pharmacology and Therapeutics, 84, 243247.

N. L. Benowitz , C. N. Lessov-Schlaggar , G. E. Swan , & P. Jacob 3rd. (2006). Female sex and oral contraceptive use accelerate nicotine metabolism. Clinical Pharmacology and Therapeutics, 79, 480488.

N. L. Benowitz , G. E. Swan , P. Jacob 3rd., C. N. Lessov-Schlaggar , & R. F. Tyndale (2006). CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clinical Pharmacology and Therapeutics, 80, 457467.

A. W. Bergen , D. V. Conti , D. Van Den Berg , W. Lee , J. Liu , D. Li , . . . G. E. Swan (2009). Dopaminergic genes and nicotine dependence in treatment seeking and community smokers. Neuropsychopharmacology, 34, 22522264.

D. Carmelli , G. E. Swan , C. DeCarli , & T. Reed (2002). Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins. Biological Psychology, 61, 139155.

D. Carmelli , G. E. Swan , D. Robinette , & R. Fabsitz (1992). Genetic influence on smoking: A study of male twins. New England Journal of Medicine, 327, 829833.

D. V. Conti , W. Lee , D. Li , J. Liu , D. Van Den Berg , P. D. Thomas , . . . C. Lerman , for the Pharmacogenetics of Nicotine Addiction and Treatment Consortium. (2008). Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Human Molecular Genetics, 17, 28342848.

M. Falcone , C. Jepson , N. Benowitz , A. W. Bergen , A. Pinto , E. P. Wileyto , . . . R. Ray (2011). Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers. Nicotine & Tobacco Research, 13, 498503.

A. C. Heath , D. R. Nyholt , R. Neuman , P. A. Madden , K. K. Bucholz , R. D. Todd , . . . N. G. Martin (2003). Zygosity diagnosis in the absence of genotypic data: An approach using latent class analysis. Twin Research, 6, 2226.

P. Jacob 3rd., N. L. Benowitz , & A. Shulgin (1988). Synthesis of optically pure deuterium labeled nicotine, nornicotine and cotinine. Journal of Labelled Compounds and Radiopharmaceuticals, 25, 11171128.

P. Jacob 3rd., L. Yu , M. Wilson , & N. L. Benowitz (1991). Selected ion monitoring method for determination of nicotine, cotinine and deuterium-labeled analogs: Absence of an isotope effect in the clearance of (S)-nicotine-3’,3’-d2 in humans. Biological Mass Spectrometry, 20, 247252.

E. Krishnan , C. N. Lessov-Schlaggar , R. E. Krasnow , & G. E. Swan (2012). Nature versus nurture in gout: A twin study. American Journal of Medicine, 125, 499504.

W. Lee , R. Ray , A. W. Bergen , G. E. Swan , P. Thomas , R. F. Tyndale , . . . D. V. Conti (2012). DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers. Pharmacogenetics & Genomics, 22, 551554.

C. N. Lessov-Schlaggar , G. E. Swan , C. DeCarli , R. E. Krasnow , T. Reed , P. A. Wolf , & D. Carmelli (2012). Longitudinal genetic analysis of brain volumes in normal elderly males: The NHLBI twin study. Neurobiology of Aging, 33, 636644.

C. N. Lessov-Schlaggar , G. E. Swan , T. Reed , P. A. Wolf , & D. Carmelli (2007). Longitudinal genetic analysis of executive function in elderly men. Neurobiology of Aging, 28, 17591768.

J. Lin , G. E. Swan , P. G. Shields , N. L. Benowitz , J. Gu , C. I. Amos , M. de Andrade , M. R. Spitz , & X. Wu (2007). Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: Genotype-phenotype correlation. Cancer Epidemiology Biomarkers and Prevention, 16, 20652071.

J. C. Mwenifumbo , C. N. Lessov-Schlaggar , Q. Zhou , R. E. Krasnow , G. E. Swan , N. L. Benowitz , & R. F. Tyndale (2008). Identification of novel CYP2A6*1B variants: The CYP2A6*1B allele is associated with faster in vivo nicotine metabolism. Clinical Pharmacology and Therapeutics, 83, 115121.

A. Pfefferbaum , E. V. Sullivan , & D. Carmelli (2001). Genetic regulation of regional microstructure of the corpus callosum in late life. Neuroreport, 12, 16771681.

G. Pickering & A. Leplege (2011). Herpes zoster pain, postherpetic neuralgia, and quality of life in the elderly. Pain Practice, 11, 397402.

D. Ruau , J. T. Dudley , R. Chen , N. G. Phillips , G. E. Swan , L. C. Lazzeroni , . . . M. S. Angst (2012). Integrative approach to pain genetics identifies pain sensitivity loci across diseases. PLoS Computional Biology, 8, e1002538.

S. Sarna , J. Kaprio , P. Sistonen , & M. Koskenvuo (1978). Diagnosis of twin zygosity by mailed questionnaire. Human Heredity, 28, 241254.

E. V. Sullivan , A. Pfefferbaum , G. E. Swan , & D. Carmelli (2001). Heritability of hippocampal size in elderly twin men: Equivalent influence from genes and environment. Hippocampus, 11, 754762.

G. E. Swan , N. L. Benowitz , P. Jacob 3rd., C. N. Lessov , R. F. Tyndale , K. Wilhelmsen , . . . M. Wambach (2004). Pharmacogenetics of nicotine metabolism in twins: Methods and procedures. Twin Research, 7, 435448.

G. E. Swan , N. L. Benowitz , C. N. Lessov , P. Jacob 3rd., R. F. Tyndale , & K. Wilhelmsen (2005). Nicotine metabolism: The impact of CYP2A6 on estimates of additive genetic influence. Pharmacogenetics & Genomics, 15, 115125.

G. E. Swan , D. Carmelli , & L. R. Cardon (1996). The consumption of tobacco, alcohol, and coffee in Caucasian male twins: A multivariate genetic analysis. Journal of Substance Abuse, 8, 1931.

G. E. Swan , D. Carmelli , & L. R. Cardon (1997). Heavy consumption of alcohol, cigarettes, and coffee in male twins. Journal of Studies in Alcohol, 58, 182190.

G. E. Swan , & C. N. Lessov-Schlaggar (2009). Tobacco addiction and pharmacogenetics of nicotine metabolism. Journal of Neurogenetics, 23, 262271.

G. E. Swan , & D. Carmelli (2002). Evidence for genetic mediation of executive control: A study of aging male twins. Journals of Gerontology Series B Psychological Sciences and Social Sciences, 57, 133143.

G. E. Swan , H. S. Javitz , L. M. Jack , J. Wessel , M. Michel , D. A. Hinds , . . . A. W. Bergen (2011). Varenicline for smoking cessation: Nausea severity and variation in nicotinic receptor genes. Pharmacogenomics Journal, 12, 349358.

G. E. Swan , C. N. Lessov-Schlaggar , A. W. Bergen , Y. He , R. F. Tyndale , & N. L. Benowitz (2009). Genetic and environmental influences on the ratio of 3’hydroxycotinine to cotinine in plasma and urine. Pharmacogenetics & Genomics, 19, 388398.

G. E. Swan , J. B. McClure , L. M. Jack , S. M. Zbikowski , H. S. Javitz , S. L. Catz , & T. A. McAfee (2010). Behavioral counseling and varenicline treatment for smoking cessation. American Journal of Preventive Medicine, 38, 482490.

G. E. Swan , T. Reed , L. M. Jack , B. L. Miller , T. Markee , P. A. Wolf , . . . D. Carmelli (1999). Differential genetic influence for components of memory in aging adult twins. Archives of Neurology, 56, 11271132.

J. Wessel , S. M. McDonald , D. A. Hinds , R. P. Stokowski , H. S. Javitz , M. Kennemer , . . . A. W. Bergen (2010). Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrom test for nicotine dependence. Neuropsychopharmacology, 35, 23922402.

X. Wu , M. R. Spitz , C. I. Amos , J. Lin , L. Shao , J. Gu , . . . G. E. Swan (2006). Mutagen sensitivity has high heritability: Evidence from a twin study. Cancer Research, 66, 59935996.

J. Xing , M. Chen , C. G. Wood , J. Lin , M. R. Spitz , J. Ma , . . . X. Wu (2008). Mitochondrial DNA content: Its genetic heritability and association with renal cell carcinoma. Journal of the National Cancer Institute, 100, 11041112.

N. Zaitlen , & P. Kraft (2012). Heritability in the genome-wide association era. Human Genetics, 131, 16551664.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: