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Prospects of royal jelly as a potential natural feed additive in poultry diets

  • M. SAEED (a1), S.A. KALHORO (a2), M. NAVEED (a3), F.U. HASSAN (a4), M. UMAR (a5), M. RASHID (a2), S.A. MEMON (a2), F. SOOMRO (a6), M.A. ARAIN (a5) and S. CHAO (a1)...
Abstract

Royal Jelly (RJ) is product from bees that is used to feed larvae in the hive as well as a main nutritional source for the queen honey bee. It has various important biological activities including as an antioxidant, immunomodulatory, anti-inflammatory, antimicrobial, cholesterol-lowering, and growth promoter activities and has the ability for inhibition of certain enzymatic degradation. It can be used for the improvement of growth performance, gut health and quality and safety of animal products in poultry due to its antioxidant and immune modulating properties. The antioxidant activity of RJ is mainly due to the presence of polyphenolic compounds. It is an excellent source of B and C vitamins and folic acid. The mineral profile of RJ is useful as it contains major macro and micro minerals. Studies conducted on supplementation with RJ in poultry diets have shown a significant increase in body weight, egg production, and immune levels and is especially useful in organic production. Supplementation of RJ at the level of 10 and 15 mg/kg in layer diets positively influenced egg weight (by 5.0% and 4.8% respectively), egg production (10.5% and 11.0% respectively), weight gain of hens (7.0% and 6.5% respectively) and yolk pigmentation (9.5% and 9.7% respectively). Total leukocyte and erythrocyte counts in the diet containing 200 mg/kg RJ were significantly higher than the diet contained 100 mg/kg or the unsupplemented control group. However, the heterophil/lymphocyte ratio and heterophil percent were reduced in RJ-fed groups. Supplementing poultry diets with RJ offers an opportunity to maximise profit from safe and high quality poultry production.

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Corresponding author: sunchao2775@163.com
References
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ABD-ALLAH, S.M. (2010) Effect of royal jelly on bovine sperm characteristics during post-thaw incubation in vitro. Revista Veterinaria 21: 81-85.
ABDEL-HAFEZ, S.M.N., RIFAAI, R.A. and ABDELZAHER, W.Y. (2017) Possible protective effect of royal jelly against cyclophosphamide induced prostatic damage in male albino rats; a biochemical, histological and immuno-histo-chemical study. Biomedicine & Pharmacotherapy 90: 15-23.
AHANGARI, Y.J., HASHEMI, S., AKHLAGHI, A., ATASHI, H., ESMAILI, Z., GHORBANI, M., MASTANI, R., AZADEGAN, A. and DAVOODI, H. (2013) Effect of in ovo injection of royal jelly on post-hatch growth performance and immune response in broiler chickens challenged with newcastle disease virus. Iranian Journal of Applied Animal Science 3: 201-206.
ARPÁŠOVÁ, H., HAŠČÍK, P., PISTOVÁ, V., MELLEN, M., GÁLIK, B. and FIK, M. (2016) The effect of propolis extract on internal quality parameters of table eggs. Animal Science and Biotechnologies 49: 10-15.
ASLAN, Z. and AKSOY, L. (2015) Anti-inflammatory effects of royal jelly on ethylene glycol induced renal inflammation in rats. International Brazalina Journal of Urology 41: 1008-1013.
BABAEI, S., RAHIMI, S., TORSHIZI, M.A.K., TAHMASEBI, G. and MIRAN, S.N.K. (2016) Effects of propolis, royal jelly, honey and bee pollen on growth performance and immune system of Japanese quails. Veterinary Research Forum 7: 13-20.
BARNUŢIU, L.I., MĂRGHITAŞ, L.A., DEZMIREAN, D.S., MIHAI, C.M. and BOBIŞ, O. (2011) Chemical composition and antimicrobial activity of royal jelly-review. Scientific Papers Animal Science and Biotechnologies 44: 67-72.
BÍLIKOVA, K., HUANG, S.C., LIN, I.P., ŠIMUTH, J. and PENG, C.C. (2015) Structure and antimicrobial activity relationship of royalisin, an antimicrobial peptide from royal jelly of apis mellifera. Peptides 68: 190-196.
BLUM, M.S., NOVAK, A.F. and TABER, S. (1959) 10-hydroxy-δ2-decenoic acid, an antibiotic found in royal jelly. Science 130: 452-453.
BONOMI, A., BONOMI, B., FORMAGGIONI, P. and QUARANTELLI, A. (2000) The use of royal jelly in feeding laying hens. Rivista di Scienza dell'Alimentazione 29: 339-352.
BOSELLI, E., CABONI, M.F., SABATINI, A.G., MARCAZZAN, G.L. and LERCKER, G. (2003) Determination and changes of free amino acids in royal jelly during storage. Apidologie 34: 129-137.
CHEN, D., LIU, F., WAN, J.-B., LAI, C.Q. and SHEN, L.R. (2017) Effect of major royal jelly proteins on spatial memory in aged rats: Metabolomics analysis in urine. Journal of Agricultural and food Chemistry 65: 3151-3159.
EL-TARABANY, M.S. (2017) Effect of Royal Jelly on behavioural patterns, feather quality, egg quality and some haematological parameters in laying hens at the late stage of production. Journal of Animal Physiology and Animal Nutrition 102: e599-e606.
ENFEKSIYONU, S.O.İ.İ.S. and ARı, Ö. (2014) Antibacterial effect of royal jelly for preservation of implant-related spinal infection in rat. Turkish Neurosurgery 24: 249-252.
FUJI, A., KOBAYASHI, S. and KUBOYAMA, N. (1990) Augmantation of wound healing by royal jelly in streptozocindiabetic rats. Japanese Journal of Pharmacology 53: 331-337.
FUJIWARA, S., IMAI, J., FUJIWARA, M., YAESHIMA, T., KAWASHIMA, T. and KOBAYASHI, K. (1990) A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin. Journal of Biological Chemistry 265: 11333-11337.
GUNALDI, O., DAGLIOGLU, Y.K., TUGCU, B., KIZILYILDIRIM, S., POSTALCI, L., OFLUOGLU, E. and KOKSAL, F. (2014) Antibacterial effect of royal jelly for preservation of implant-related spinal infection in rat. Turkish Neurosurgery 24: 249-252.
GUO, H., SAIGA, A., SATO, M., MIYAZAWA, I., SHIBATA, M., TAKAHATA, Y. and MORIMATSU, F. (2007) Royal jelly supplementation improves lipoprotein metabolism in humans. Journal of Nutritional Science and Vitaminology 53: 345-348.
HASHEMIPOUR, M.A., TAVAKOLINEGHAD, Z., ARABZADEH, S., IRANMANESH, Z. and NASSAB, S. (2014) Antiviral activities of honey, royal jelly, and acyclovir against hsv-1. Wounds: A Compendium of Clinical Research and Practice 26: 47-54.
JAFARI, Y., HASHEMI, S.R. and AKHLAGHI, A. (2013) Effect of in ovo injection of royal jelly on post-hatch growth performance and immune response in broiler chickens challenged with Newcastle disease Virus. Iranian Journal of Applied Animal Science 3: 201-206.
JALALI, A.S., NAJAFI, G., HOSSEINCHI, M. and SEDIGHNIA, A. (2015) Royal jelly alleviates sperm toxicity and improves in vitro fertilization outcome in stanozolol-treated mice. Iranian Journal of Reproductive Medicine 13: 15-22.
JAMNIK, P., GORANOVIČ, D. and RASPOR, P. (2007) Antioxidative action of royal jelly in the yeast cell. Experimental Gerontology 42: 594-600.
JUSTIN, O.S., MIZRAHI, A. and LENSKY, Y. (1996) Chemical composition and application, in: Bee products. London, UK: Plenum 2: 15-26.
KAMAKURA, M., MITANI, N., FUKUDA, T. and FUKUSHIMA, M. (2001) Antifatigue effect of fresh royal jelly in mice. Journal of Nutritional Science and Vitaminology 47: 394-401.
KANBUR, M., ERASLAN, G., BEYAZ, L., SILICI, S., LIMAN, B.C., ALTıNORDULU, Ş. and ATASEVER, A. (2009) The effects of royal jelly on liver damage induced by paracetamol in mice. Experimental and Toxicologic Pathology 61: 123-132.
KODAI, T., UMEBAYASHI, K., NAKATANI, T., ISHIYAMA, K. and NODA, N. (2007) Compositions of royal jelly ii. Organic acid glycosides and sterols of the royal jelly of honeybees (apis mellifera). Chemical and Pharmaceutical Bulletin 55: 1528-1531.
KOHNO, K., OKAMOTO, I., SANO, O., ARAI, N., IWAKI, K., IKEDA, M. and KURIMOTO, M. (2004) Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. Bioscience, Biotechnology, and Biochemistry 68: 138-145.
KRYLOV, V. and SOKOLSKII, C. (2000) Royal jelly (in Russian). Agroprompoligrafist Krasnodar; 214 pp.
KURKURE, N., KOGNOLE, S., PAWAR, S., GANORKAR, A., BHANDARKAR, A., INGLE, V. and KALOREY, D. (2000) Effect of royal jelly as immunonomodulator in chicks. Journal of Immunology & Immunopathology 2: 84-87.
MAHMOUD, F.A. (2016) Impact of Chinese royal jelly on performance, behaviour and some blood parameters in broilers reared under high stocking density. Asian Journal of Animal and Veterinary Advances 11: 620-628.
MAJTAN, J., KOVÁČOVÁ, E., BÍLIKOVÁ, K. and ŠIMÚTH, J. (2006) The immunostimulatory effect of the recombinant apalbumin 1-major honeybee royal jelly protein-on tnfα release. International Immunopharmacology 6: 269-278.
MOGHADDAM, A., BORJI, M. and KOMAZANI, D. (2014) Hatchability rate and embryonic growth of broiler chicks following in ovo injection royal jelly. British Poultry Science 55: 391-397.
MUFARREJ, S. and EL-SARAG, M. (1997) Effects of royal jelly on the humoral antibody response and blood chemistry of chickens. Journal of Applied Animal Research 12: 41-47.
NAGAI, T. and INOUE, R. (2004) Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chemistry 84: 181-186.
NAGAI, T., INOUE, R., SUZUKI, N. and NAGASHIMA, T. (2006) Antioxidant properties of enzymatic hydrolysates from royal jelly. Journal of Medicinal Food 9: 363-367.
NAKAJIMA, Y., TSURUMA, K., SHIMAZAWA, M., MISHIMA, S. and HARA, H. (2009) Comparison of bee products based on assays of antioxidant capacities. BMC Complementary and Alternative Medicine 9: 4.
OKAMOTO, I., TANIGUCHI, Y., KUNIKATA, T., KOHNO, K., IWAKI, K., IKEDA, M. and KURIMOTO, M. (2003) Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sciences 73: 2029-2045.
OSMAN, H. and ELGADIR, A. (2015) Effect of royal jelly on humoral antibody response, blood chemistry and performance of broiler &layer chickens. A master degree thesis. University of Khartoum for the degree of Master of Science (Zoology).
PAVEL, C.I., MĂRGHITAŞ, L.A., BOBIŞ, O., DEZMIREAN, D.S., ŞAPCALIU, A., RADOI, I. and MĂDAŞ, M.N. (2011) Biological activities of royal jelly-review. Scientific Papers Animal Science and Biotechnologies 44: 108-118.
PREMRATANACHAI, P. and CHANCHAO, C. (2014) Review of the anticancer activities of bee products. Asian Pacific Journal of Tropical Biomedicine 4: 337-344.
RAMADAN, M.F. and AL-GHAMDI, A. (2012) Bioactive compounds and health-promoting properties of royal jelly: A review. Journal of Functional Foods 4: 39-52.
SABATINI, A.G., MARCAZZAN, G.L., CABONI, M.F., BOGDANOV, S. and ALMEIDA-MURADIAN, L. (2009) Quality and standardisation of royal jelly. Journal of ApiProduct and ApiMedical Science 1: 1-6.
SANTOS, K.S., DOS SANTOS, L.D., MENDES, M.A., DE SOUZA, B.M., MALASPINA, O. and PALMA, M.S. (2005) Profiling the proteome complement of the secretion from hypopharyngeal gland of africanized nurse-honeybees (apis mellifera l.). Insect Biochemistry and Molecular Biology 35: 85-91.
SERRA BONVEHI, J. and ESCOLA JORDA, R. (1991) Study of the microbiological quality and bacteriostatic activity of queen food (royal jelly): Effect of organic acids. Deutsche Lebensmittel-Rundschau 87: 256-529.
SEVEN, I., ŞIMŞEK, U.G., GOKÇE, Z., SEVEN, P.T., ARSLAN, A. and YILMAZ, O. (2014) The effects of royal jelly on performance and fatty acid profiles of different tissues in quail (coturnix coturnix japonica) reared under high stocking density. Turkish Journal of Veterinary & Animal Sciences 38: 271-277.
SEVEN, P.T., ARSLAN, A.S., OZCELIK, M., SIMSEK, U.G. and SEVEN, I. (2016) Effects of propolis and royal jelly dietary supplementation on performance, egg characteristics, lipid peroxidation, antioxidant enzyme activity and mineral levels in Japanese quail. European Poultry Science 80: DOI: 10.1399/eps.2016.138.
SIAVASH, M., SHOKRI, S., HAGHIGHI, S., MOHAMMADI, M., SHAHTALEBI, M.A. and FARAJZADEHGAN, Z. (2011) The efficacy of topical royal jelly on diabetic foot ulcers healing: A case series. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 16: 904-909.
STEEL, R.G.D. and TORRIE, J.H. (1980) Principles and procedures of statistics. A Biometrical approach. 2nd ed. .New York, USA: McGraw-Hill Book Company; pp. 112-121.
STOCKER, A. (2003) Isolation and characterisation of substances from Royal Jelly. PhD Thesis; Université d'Orléans; Orléans (France).
SUZUKI, K.M., ISOHAMA, Y., MARUYAMA, H., YAMADA, Y., NARITA, Y., OHTA, S., ARAKI, Y., MIYATA, T. and MISHIMA, S. (2008) Estrogenic activities of fatty acids and a sterol isolated from royal jelly. Evidence-Based Complementary and Alternative Medicine 5: 295-302.
TAKENAKA, T., YATSUNAMI, K. and ECHIGO, T. (1986) Changes in quality of royal jelly during storage. Nippon Shokuhin Kogyo Gakkaishi 33: 1-7.
TOKUNAGA, K., SUZUKI, K.-M., YOSHIDA, C., MARUYAMA, H., FUTAMURA, Y., ARAKI, Y. and MISHIMA, S. (2004) Antihypertensive mechanism of royal jelly treated with protease in spontaneously hypertensive rats. Journal of the Japanese Society for Food Science and Technology (Japan) 51: 34-37.
TOWNSEND, G.F., MORGAN, J.F., TOLNAI, S., HAZLETT, B., MORTON, H.J. and SHUEL, R.W. (1960) Studies on the in vitro antitumor activity of fatty acids. I. 10-hydroxy-2-decenoic acid from royal jelly. Cancer Research 20: 503-510.
TSENG, J.M., HUANG, J.R., HUANG, H.C., TZEN, J.T., CHOU, W.M. and PENG, C.C. (2011) Facilitative production of an antimicrobial peptide royalisin and its antibody via an artificial oil-body system. Biotechnology Progress 27: 153-161.
VEZETEU, T.V., BOBIŞ, O., MORITZ, R.F. and BUTTSTEDT, A. (2017) Food to some, poison to others-honeybee royal jelly and its growth inhibiting effect on European foulbrood bacteria. Microbiology Open 6 (1): e00397.
VIUDA-MARTOS, M., RUIZ-NAVAJAS, Y., FERNANDEZ-LOPEZ, J. and PEREZ-ALVAREZ, J.A. (2008) Functional properties of honey, propolis, and royal jelly. Journal of Food Science 73: R117-124.
VUCEVIC, D., MELLIOU, E., VASILIJIC, S., GASIC, S., IVANOVSKI, P., CHINOU, I. and COLIC, M. (2007) Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro. International Immunopharmacology 7: 1211-1220.
YONESHIRO, T., KAEDE, R., NAGAYA, K., AOYAMA, J., SAITO, M., OKAMATSU-OGURA, Y., KIMURA, K. and TERAO, A. (2017) Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obesity Research and Clinical Practice 12 (1): 127-137, doi.org/10.1016/j.orcp.2016.12.006.
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World's Poultry Science Journal
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  • EISSN: 1743-4777
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