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Vitagenes in poultry production: Part 2. Nutritional and internal stresses

Published online by Cambridge University Press:  24 October 2016

P.F. SURAI  and
V.I. FISININ
P.F. SURAI*
Affiliation:
Trakia University, Stara Zagora, Bulgaria Szent Istvan University, Godollo, Hungary Sumy National Agrarian University, Sumy, Ukraine Odessa National Academy of Food Technologies, Ukraine Russian Academy of Science, Moscow, Russia
V.I. FISININ
Affiliation:
Russian Academy of Science, Moscow, Russia All Russian Institute of Poultry Husbandry, Sergiev Posad, Russia
*
Corresponding author: psurai@feedfood.co.uk
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Abstract

Commercial poultry production is associated with various stresses affecting productive and reproductive performance of birds and their health status. Recently the vitagene concept has received substantial attention. In fact, the term vitagenes refers to a group of genes that are responsible for preserving cellular homeostasis in stress conditions. These genes play a crucial role in cell and whole organism adaptation to stress by regulating additional synthesis of stress resistance proteins, including heat shock proteins, thioredoxins, sirtuins and superoxide dismutase. Among four major types of stress, nutritional stresses have a special place, being detrimental for productive and reproductive performances of poultry. In particular, mycotoxins are unavoidable contaminants of poultry feed and at molecular level they cause oxidative stress in the body. Oxidised fat and nutrient imbalances are also detrimental for gut health, immunity, growth and development of chickens. Internal stresses, including peak of egg production and vaccinations are also of great importance for poultry production. Therefore, the development of the effective antioxidant solutions to decrease negative consequences of nutritional and internal stresses is an important task for poultry scientists. One of such approaches is based on the vitagene concept which will be considered in this review.

Keywords

poultrystressesoxidative stressvitagenes
Type
Reviews
Information
World's Poultry Science Journal , Volume 72 , Issue 4 , December 2016 , pp. 761 - 772
Copyright
Copyright © World's Poultry Science Association 2016 

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References

ANTONISSEN, G., MARTEL, A, PASMANS, F., DUCATELLE, R., VERBRUGGHE, E., VANDENBROUCKE, V., LI, S., HAESEBROUCK, F., VAN IMMERSEEL, F. and CROUBELS, S. (2014) The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases. Toxins(Basel) 6: 430-452.Google Scholar
APPLEGATE, T.J., SCHATZMAYR, G., PRICKEL, K., TROCHE, C. and JIANG, Z. (2009) Effect of aflatoxin culture on intestinal function and nutrient loss in laying hens. Poultry Science 88: 1235-1241.Google Scholar
ASGHAR, A., LIN, C.F., GRAR, J.I., BUCKLEY, D.J., BOOREN, A.M., CRACKEL, R.L. and FLEGAL, C.J. (1989) Influence of oxidised dietary oil and antioxidant supplementation on membrane-bound lipid stability in broiler meat. British Poultry Science 30: 815-823.CrossRefGoogle ScholarPubMed
AWAD, W., GHAREEB, K., BÖHM, J. and ZENTEK, J. (2013) The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicity. Toxins(Basel) 5: 912-925.CrossRefGoogle ScholarPubMed
BERZINA, N., MARKOVS, J., DIZHBITE, T., APSITE, M., VASILYEVA, S., BASOVA, N., SMIRNOVA, G. and ISAJEVS, S. (2013) Oxidative stress and innate immunity status in chickens exposed to high dose of ascorbic acid. Cell Biochemistry and Function 31: 551-559.CrossRefGoogle ScholarPubMed
BILLEK, G. (2000) Health aspects of thermoxidised oils and fats. European Journal of Lipid Science and Technology 120: 587-593.Google Scholar
BOU, R., GRIMPA, S., GUARDIOLA, F., BARROETA, A.C. and CODONY, R. (2006) Effects of various fat sources, alpha-tocopheryl acetate, and ascorbic acid supplements on fatty acid composition and alpha-tocopherol content in raw and vacuum-packed, cooked dark chicken meat. Poultry Science 85: 1472-1481.Google Scholar
CABEL, M.C. and WALDROUP, P.W. (1989) Ethoxyquin and ethylenediaminetetraacetic acid for the prevention of rancidity in rice bran stored at elevated temperature and humidity for various lengths of time. Poultry Science 68: 438-442.Google Scholar
CALABRESE, V., GUAGLIANO, E., SAPIENZA, M., PANEBIANCO, M., CALAFATO, S., PULEO, E., PENNISI, G., MANCUSO, C., BUTTERFIELD, D.A. and STELLA, A.G. (2007) Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. Neurochemical Research 32: 757-773.Google Scholar
CALABRESE, V., CORNELIUS, C., DINKOVA-KOSTOVA, A.T. and CALABRESE, E.J. (2009) Vitagenes, cellular stress response, and acetylcarnitine: relevance to hormesis. Biofactors 35: 146-160.Google Scholar
CALABRESE, V., CORNELIUS, C., DINKOVA-KOSTOVA, A.T., IAVICOLI, I., DI PAOLA, R., KOVERECH, A., CUZZOCREA, S., RIZZARELLI, E. and CALABRESE, E.J. (2012) Cellular stress responses, hermetic phytochemicals and vitagenes in aging and longevity. Biochimica et Biophysica Acta 1822: 753-783.Google Scholar
CINAR, M., YILDIRIM, E., YIGIT, A.A., YALCINKAYA, I., DURU, O., KISA, U. and ATMACA, N. (2014) Effects of dietary supplementation with vitamin C and vitamin E and their combination on growth performance, some biochemical parameters, and oxidative stress induced by copper toxicity in broilers. Biological Trace Element Research 158: 186-196.CrossRefGoogle ScholarPubMed
CORNELIUS, C., PERROTTA, R., GRAZIANO, A., CALABRESE, E.J. and CALABRESE, V. (2013) Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a ‘chi’. Immunity & Ageing 10:15.Google Scholar
DATTILO, S., MANCUSO, C., KOVERECH, G., DI MAURO, P., ONTARIO, M.L., PETRALIA, C.C., PETRALIA, A., MAIOLINO, L., SERRA, A., CALABRESE, E.J. and CALABRESE, V. (2015) Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases. Immunity & Ageing 12: 20.CrossRefGoogle ScholarPubMed
DELLES, R.M., XIONG, Y.L., TRUE, A.D., AO, T. and DAWSON, K.A. (2014) Dietary antioxidant supplementation enhances lipid and protein oxidative stability of chicken broiler meat through promotion of antioxidant enzyme activity. Poultry Science 93: 1561-1570.Google Scholar
DELLES, R.M., XIONG, Y.L., TRUE, A.D., AO, T. and DAWSON, K.A. (2015) Augmentation of water-holding and textural properties of breast meat from oxidatively stressed broilers by dietary antioxidant regimens. British Poultry Science 56: 304-314.Google Scholar
DHABHAR, F.S. (2014) Effects of stress on immune function: the good, the bad, and the beautiful. Immunologic Research 58: 193-210.Google Scholar
DIETERT, R.R., GOLEMBOSKI, K.A. and AUSTIC, R.E. (1994) Environment-immune interactions. Poultry Science 73: 1062-1076.Google Scholar
DOHMS, J.E. and METZ, A. (1991) Stress-mechanisms of immunosuppression. Veterinary Immunology and Immunopathology 30: 89-109.CrossRefGoogle Scholar
EDER, K., SUELZLE, A., SKUFCA, P., BRANDSCH, C. and HIRCHE, F. (2003) Effects of dietary thermoxidised fats on expression and activities of hepatic lipogenic enzymes in rats. Lipids 38: 31-38.CrossRefGoogle Scholar
EHR, I.J., KERR, B.J. and PERSIA, M.E. (2015) Effects of peroxidised corn oil on performance, AMEn, and abdominal fat pad weight in broiler chicks. Poultry Science 94: 1629-1634.CrossRefGoogle Scholar
ENGBERG, R.M., LAURIDSEN, C., JENSEN, S.K. and JAKOBSEN, K. (1996) Inclusion of oxidised vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. Poultry Science 75: 1003-1011.CrossRefGoogle ScholarPubMed
FISININ, V.I. and SURAI, P.F. (2011) Effective protection from stresses in poultry production: from vitamins to vitagenes. Part 1. Poultry and Poultry Products(Ptitza I Ptitzeproducti, Moscow) 5: 23-26.Google Scholar
FISININ, V.I. and SURAI, P.F. (2011a) Effective protection from stresses in poultry production: from vitamins to vitagenes. Part 2. Poultry and Poultry Products(Ptitza I Ptitzeproducti, Moscow) 6: 10-13.Google Scholar
FISININ, V.I. and SURAI, P.F. (2012a) Properties and toxicity of DON. Mycotoxins and antioxidants: Uncompromising fighting. Part 1. Animal Production of Russia(Zhivotnovodstvo Rossii) 5: 11-14.Google Scholar
FISININ, V.I. and SURAI, P.F. (2012b) Properties and toxicity of DON. Mycotoxins and antioxidants: Uncompromising fighting. Part 2. Animal Production of Russia(Zhivotnovodstvo Rossii, Russia) 6: 3-5.Google Scholar
FISININ, V.I. and SURAI, P.F. (2012c) Mycotoxins and antioxidants: Uncompromising fighting. Ochratoxin A. Part 1. Compounded Feed(Kombikorma, Russia) 3: 55-60.Google Scholar
FISININ, V.I. and SURAI, P.F. (2012d) Mycotoxins and antioxidants: Uncompromising fighting. Ochratoxin A. Part 2. Compounded Feed(Kombikorma, Russia) 5: 59-60.Google Scholar
FISININ, V.I. and SURAI, P.F. (2012e) Mycotoxins and antioxidants: Uncompromising fighting. T-toxin - metabolism and toxicity. Part 1. Poultry and Poultry Products(Ptiza i Ptizeproducti, Russia) 3: 38-41.Google Scholar
FISININ, V.I. and SURAI, P.F. (2012f) Mycotoxins and antioxidants: Uncompromising fighting. T-toxin - mechanisms of toxicity and protection. Part 2 . Poultry and Poultry Products 2012(Ptizai Ptizeproducti, Russia) 4: 36-39.Google Scholar
FISININ, V.I. and SURAI, P.F. (2013a) Immunity in modern animal and poultry production: from theory to practical aspects of immunomodulation. Russian Poultry Science(Ptitsevodstvo, Russia) 5: 4-10.Google Scholar
FISININ, V.I. and SURAI, P.F. (2013b) Gut immunity in birds: facts and thinking. Agricultural Biology(Selskokhozaistvennaya Biologia, Russia) 4: 1-25.Google Scholar
FUSSELL, L.W. (1998) Poultry industry strategies for control of immunosuppressive diseases. Poultry Science 77: 1193-1196.CrossRefGoogle ScholarPubMed
GAIGÉ, S., DJELLOUL, M., TARDIVEL, C., AIRAULT, C., FÉLIX, B., JEAN, A., LEBRUN, B., TROADEC, J.D. and DALLAPORTA, M. (2014) Modification of energy balance induced by the food contaminant T-2 toxin: a multimodal gut-to-brain connection. Brain, Behaviour and Immunology 37: 54-72.Google Scholar
GALVANO, F., PIVA, A., RITIENI, A. and GALVANO, G. (2001) Dietary strategies to counteract the effects of mycotoxins: a review. Journal of Food Protection 64: 120-131.Google Scholar
GALVIN, K., MORRISSEY, P.A. and BUCKLEY, D.J. (1997) Influence of dietary vitamin E and oxidised sunflower oil on the storage stability of cooked chicken muscle. British Poultry Science 38: 499-504.Google Scholar
GHAREEB, K., AWAD, W.A., BÖHM, J. and ZEBELI, Q. (2015) Impacts of the feed contaminant deoxynivalenol on the intestine of monogastric animals: poultry and swine. Journal of Applied Toxicology 35: 327-337.CrossRefGoogle ScholarPubMed
GRENIER, B. and APPLEGATE, T.J. (2013) Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals. Toxins(Basel) 5: 396-430.Google Scholar
GROBAS, S., MENDEZ, J., DE BLAS, C. and MATEOS, G.G. (1999) Influence of dietary energy, supplemental fat and linoleic acid concentration on performance of laying hens at two ages. British Poultry Science 40: 681-687.CrossRefGoogle ScholarPubMed
GUO, M., HUANG, K., CHEN, S., QI, X., HE, X., CHENG, W.H., LUO, Y., XIA, K. and XU, W. (2014) Combination of metagenomics and culture-based methods to study the interaction between ochratoxin A and gut microbiota. Toxicological Sciences 141: 314-323.CrossRefGoogle Scholar
HEUSSNER, A.H. and BINGLE, L.E. (2015) Comparative Ochratoxin Toxicity: A Review of the Available Data. Toxins(Basel) 7: 4253-4282.Google Scholar
HOERR, F.J. (2010) Clinical aspects of immunosuppression in poultry. Avian Diseases 54: 2-15.CrossRefGoogle ScholarPubMed
HUWIG, A., FREIMUND, S., KÄPPELI, O. and DUTLER, H. (2001) Mycotoxin detoxication of animal feed by different adsorbents. Toxicology Letters 122:179-188.Google Scholar
INGRAO, F., RAUW, F., LAMBRECHT, B. and VAN DEN BERG, T. (2013) Infectious Bursal Disease: a complex host-pathogen interaction. Developmental and Comparative Immunology 41: 429-438.Google Scholar
JENSEN, C., ENGBERG, R., JAKOBSEN, K., SKIBSTED, L.H. and BERTELSEN, G. (1997) Influence of the oxidative quality of dietary oil on broiler meat storage stability. Meat Science 47: 211-222.Google Scholar
JIANG, M., PENG, X., FANG, J., CUI, H., YU, Z. and CHEN, Z. (2015) Effects of aflatoxin b1 on T-cell subsets and mRNA expression of cytokines in the intestine of broilers. International Journal of Molecular Sciences 16: 6945-6959.Google Scholar
KATIKA, M.R., HENDRIKSEN, P.J., VAN LOVEREN, H. and PEIJNENBURG, A.C.M. (2015) Characterization of the modes of action of deoxynivalenol (DON) in the human Jurkat T-cell line. Journal of Immunotoxicology 12: 206-216.Google Scholar
KLASING, K.C. (1998) Nutritional modulation of resistance to infectious diseases. Poultry Science 77: 1119-1125.CrossRefGoogle ScholarPubMed
KUMAR, R., ALAM, S., CHAUDHARI, B.P., DWIVEDI, P.D., JAIN, S.K., ANSARI, K.M. and DAS, M. (2013) Ochratoxin A-induced cell proliferation and tumour promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1. Carcinogenesis 34: 647-657.Google Scholar
LAI, H.T.L., NIEUWLAND, M.G.B., KEMP, B.A., AARNINK, J.A. and PARMENTIER, H.K. (2011) Effects of repeated intratracheally administered lipopolysaccharide on primary and secondary specific antibody responses and on body weight gain of broilers. Poultry Science 90: 337-351.CrossRefGoogle ScholarPubMed
LALLÈS, J.P., LESSARD, M. and BOUDRY, G. (2009) Intestinal barrier function is modulated by short-term exposure to fumonisin B1 in Ussing chambers. Veterinary Research Communications 33: 1039-1043.Google Scholar
LAUTERT, C., FERREIRO, L., WOLKMER, P., PAIM, F.C., DA SILVA, C.B., JAQUES, J.A., LOPES, S.T. and SANTURIO, J.M. (2014) Individual in vitro effects of ochratoxin A, deoxynivalenol and zearalenone on oxidative stress and acetylcholinesterase in lymphocytes of broiler chickens. Springerplus 3: 506. doi: 10.1186/2193-1801-3-506.Google Scholar
LEESON, S., NAMKUNG, H., CASTON, L., DUROSOY, S. and SCHLEGEL, P. (2008) Comparison of selenium levels and sources and dietary fat quality in diets for broiler breeders and layer hens. Poultry Science 87: 2605-2612.Google Scholar
LESSARD, M., BOUDRY, G., SÈVE, B., OSWALD, I.P. and LALLÈS, J.P. (2009) Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins. Journal of Nutrition 139: 1303-1307.CrossRefGoogle ScholarPubMed
L'ESTRANGE, J.L., CARPENTER, K.J., LEA, C.H. and PARR, L.J (1966) Nutritional effects of autoxidised fats in animal diets. 2. Beef fat in the diet of broiler chickens. British Journal of Nutrition 20: 113-122.Google Scholar
LIMONCIEL, A. and JENNINGS, P. (2014) A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity. Toxins(Basel) 6: 371-379.Google Scholar
LIN, C.F., ASGHAR, A., GRAY, J.I., BUCKLEY, D.J., BOOREN, A.M., CRACKEL, R.L. and FLEGAL, C.J. (1989) Effects of oxidised dietary oil and antioxidant supplementation on broiler growth and meat stability. British Poultry Science 30: 855-864.CrossRefGoogle ScholarPubMed
LIU, M., GAO, R., MENG, Q., ZHANG, Y., BI, C. and SHAN, A. (2014) Toxic effects of maternal zearalenone exposure on intestinal oxidative stress, barrier function, immunological and morphological changes in rats. PLoS One 9(9):e106412.Google Scholar
LIU, C.P., FU, J., LIN, S.L., WANG, X.S. and LI, S. (2014a) Effects of dietary selenium deficiency on mRNA levels of twenty-one selenoprotein genes in the liver of layer chicken. Biological Trace Element Research 159: 192-198.CrossRefGoogle ScholarPubMed
LOCHMILLER, R.L. and DEERENBERG, C. (2000) Trade-offs in evolutionary immunology: just what is the cost of immunity? OIKOS 88: 87-98.Google Scholar
LOPEZ-FERRER, S., BAUCELLS, M.D., BARROETA, A.C. and GRASHORN, M.A. (1999) Influence of vegetable oil sources on quality parameters of broiler meat. Archiv für Geflügelkunde 63: 29-35.Google Scholar
LU, T., HARPER, A.F., ZHAO, J., CORL, B.A., LEROITH, T. and DALLOUL, R.A. (2014) Effects of a dietary antioxidant blend and vitamin E on fatty acid profile, liver function, and inflammatory response in broiler chickens fed a diet high in oxidants. Poultry Science 93: 1658-1666.Google Scholar
LUAN, Y., ZHAO, J., YAO, H., ZHAO, X., FAN, R., ZHAO, W., ZHANG, Z. and XU, S. (2015) Selenium Deficiency Influences the mRNA Expression of Selenoproteins and Cytokines in Chicken Erythrocytes. Biological Trace Element Research 171: 427-436.Google Scholar
MA, Q., LI, Y., FAN, Y., ZHAO, L., WEI, H., JI, C. and ZHANG, J. (2015) Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B1-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers. Toxins(Basel) 7: 5435-5447.Google Scholar
MARIN, D.E., MOTIU, M. and TARANU, I. (2015) Food contaminant zearalenone and its metabolites affect cytokine synthesis and intestinal epithelial integrity of porcine cells. Toxins(Basel) 7: 1979-1988.CrossRefGoogle ScholarPubMed
MAURICE, D.V., LIGHTSEY, S.F., KUO-TUNG, H. and RHOADES, J.F. (1991) Comparison of GSH s-transferase activity in the rat and birds: Tissue distribution and rhythmicity in chicken (Gallus domesticus) liver. Comparative Biochemistry and Physiology 100B: 471-474.Google Scholar
MEZES, M., SURAI, P.F., SALYI, G., SPEAKE, B.K., GAAL, T. and MALDJIAN, A. (1997) Nutritional metabolic diseases in poultry and disorders of the biological antioxidant defence system. Acta Veterinaria Hungarica 45: 349-360.Google ScholarPubMed
MURUGESAN, G.R., LEDOUX, D.R., NAEHRER, K., BERTHILLER, F., APPLEGATE, T.J., GRENIER, B., PHILLIPS, T.D. and SCHATZMAYR, G. (2015) Prevalence and effects of mycotoxins on poultry health and performance, and recent development in mycotoxin counteracting strategies. Poultry Science 94: 1298-1315.Google Scholar
NAKAMURA, M., TANAKA, H., HATTORI, Y. and WATANABE, M. (1972) Biological effects of autoxidised safflower oils. Lipids 8: 566-572.Google Scholar
PAPPAS, A.C., ZOIDIS, E., SURAI, P.F. and ZERVAS, G. (2008) Selenoproteins and maternal nutrition. Comparative Biochemistry and Physiol. Part B Biochemistry & Molecular Biology 151: 361-372.Google Scholar
PAPPAS, A.C., ZOIDIS, E., FEGEROS, K., ZERVAS, G. and SURAI, P.F. (2010) Cadmium, toxicity and the antioxidant system. Npva Science Publishers, Inc., New York.Google Scholar
PENG, X., ZHANG, S., FANG, J., CUI, H., ZUO, Z. and DENG, J. (2014) Protective roles of sodium selenite against aflatoxin B1-induced apoptosis of jejunum in broilers. International Journal of Environmental Research and Public Health 11: 13130-13143.Google Scholar
PERSIA, M.E., BAKER, D.H. and PARSONS, C.M. (1994) Tolerance for excess basic zinc chloride and basic copper chloride in chicks. British Poultry Science 45: 672-676.Google Scholar
POERSCH, A.B., TROMBETTA, F., BRAGA, A.C., BOEIRA, S.P., OLIVEIRA, M.S., DILKIN, P., MALLMANN, C.A., FIGHERA, M.R., ROYES, L.F., OLIVEIRA, M.S. and FURIAN, A.F. (2014) Involvement of oxidative stress in subacute toxicity induced by fumonisin B1 in broiler chicks. Veterinary Microbiology 174: 180-185.Google Scholar
RAMYAA, P., KRISHNASWAMY, R. and PADMA, V.V. (2014) Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-κB and COX-2. Biochimica et Biophysica Acta 1840: 681-692.CrossRefGoogle ScholarPubMed
SAFAA, H.M., SERRANO, M.P., VALENCIA, D.G., FRIKHA, M., JIMÉNEZ-MORENO, E. and MATEOS, G.G. (2008) Productive performance and egg quality of brown egg-laying hens in the late phase of production as influenced by level and source of calcium in the diet. Poultry Science 87: 2043-2051.Google Scholar
SAHIN, K., SAHIN, N., KUCUK, O., HAYIRLI, A. and PRASAD, A.S. (2009) Role of dietary zinc in heat-stressed poultry: a review. Poultry Science 88: 2176-2183.Google Scholar
SANDERSON, I.R. (1999) The physicochemical environment of the neonatal intestine. American Journal of Clinical Nutrition 69: 1028S-1034S.Google Scholar
SCHWARTZ-ZIMMERMANN, H.E., FRUHMANN, P., DÄNICKE, S., WIESENBERGER, G., CAHA, S., WEBER, J. and BERTHILLER, F. (2015) Metabolism of Deoxynivalenol and Deepoxy-Deoxynivalenol in Broiler Chickens, Pullets, Roosters and Turkeys. Toxins(Basel) 7: 4706-4729.Google Scholar
SHEEHY, P.J.A., MORRISSEY, P.A. and FLYNN, A. (1993) Influence of heated vegetable oils and α-tocopheryl acetate supplementation on α-tocopherol, fatty acids and lipid peroxidation in chicken muscle. British Poultry Science 34: 367-381.Google Scholar
SHEEHY, P.J.A., MORRISSEY, P.A. and FLYNN, A. (1994) Consumption of thermally-oxidised sunflower oil by chicks reduces α-tocopherol status and increased susceptibility of tissues to lipid oxidation. British Journal of Nutrition 71: 53-65.Google Scholar
SURAI, P.F. (2002) Natural Antioxidants in Avian Nutrition and reproduction. Nottingham University Press, Nottingham, UK.Google Scholar
SURAI, P.F. (2006) Selenium in Nutrition and Health. Nottingham University Press, Nottingham, UK.Google Scholar
SURAI, P.F. (2015a) Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 4: 204-247.Google Scholar
SURAI, P.F. (2015b) Antioxidant Systems in Poultry Biology: Superoxide Dismutase. Journal of Animal Nutrition 1 (1): 8.Google Scholar
SURAI, P.F. (2015c) Carnitine Enigma: From Antioxidant Action to Vitagene Regulation. Part 2. Transcription Factors and Practical Applications. Journal of Veterinary Science & Medicine 3 (2): 17.Google Scholar
SURAI, P.F. and DVORSKA, J.E. (2005) Effects of Mycotoxins on Antioxidant Status and Immunity, in: DIAZ, D.E. (Ed) The Mycotoxin Blue Book, pp. 93-137 (Nottingham University Press, Nottingham).Google Scholar
SURAI, P.F. and FISININ, V.I. (2012a) Innovative methods of fighting stresses in poultry production: From vitamins to sirtuins and vitagenes. Effective Poultry Production(Ukraine) 8: 8-13.Google Scholar
SURAI, P.F. and FISININ, V.I. (2012b) Modern methods of fighting stresses in poultry production: from antioxidants to vitagenes. Agricultural Biology(Selskokhozaistvennaya Biologia, Russia) 4: 3-13.Google Scholar
SURAI, P.F. and FISININ, V.I. (2015) Antioxidant-Prooxidant Balance in the Intestine: Applications in Chick Placement and Pig Weaning. Journal of Veterinary Science & Medicine 3 (2): 16.Google Scholar
SURAI, P.F. and FISININ, V.I. (2016) Antioxidant system regulation: from vitamins to vitagenes, in: WATSON, R.R. & DE MEESTER, F. (Eds) Handbook of cholesterol, pp. 451-481 (Wageningen Academic Publishers, The Netherlands).Google Scholar
SURAI, P.F. and MEZES, M. (2005) Mycotoxins and Immunity: Theoretical consideration and practical applications. Praxis Veterinaria53: 71-88.Google Scholar
SURAI, P.F., MEZES, M., MELNICHUK, S.D. and FOTINA, T.I. (2008) Mycotoxins and animal health: From oxidative stress to gene expression. Krmiva 50: 35-43.Google Scholar
SURAI, P.F., MEZES, M., FOTINA, T. and DENEV, S.D. (2010) Mycotoxins in human diet: a hidden danger, in: DE MEESTER, F. ZIBADI, S. & WATSON, R.R. (Eds) Modern Dietary Fat Intakes in Disease Promotion, pp. 275-303 (Humana Press, Springer New York London).Google Scholar
TARANU, I., BRAICU, C., MARIN, D.E., PISTOL, G.C., MOTIU, M., BALACESCU, L., BERIDAN NEAGOE, I. and BURLACU, R. (2014) Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression. Toxicology Letters 232: 310-325.Google Scholar
TAVÁREZ, M.A., BOLER, D.D., BESS, K.N., ZHAO, J., YAN, F., DILGER, A.C., MCKEITH, F.K. and KILLEFER, J. (2011) Effect of antioxidant inclusion and oil quality on broiler performance, meat quality, and lipid oxidation. Poultry Science 90: 922-930.Google Scholar
WAN, Q., WU, G., HE, Q., TANG, H. and WANG, Y. (2015) The toxicity of acute exposure to T-2 toxin evaluated by the metabonomics technique. Molecular bioSystems 11: 882-891.CrossRefGoogle ScholarPubMed
WANG, J., TANG, L., GLENN, T.C. and WANG, J.S. (2016) Aflatoxin B1 induced compositional changes in gut microbial communities of male F344 rats. Toxicological Sciences 150: 54-63.Google Scholar
WANG, S.Y., BOTTJE, W., MAYNARD, P., DIBNER, J. and SHERMER, W. (1997) Effect of Santoquin and oxidised fat on liver and intestinal glutathione in broilers. Poultry Science 76: 961-967.Google Scholar
WANG, G.H., XUE, C.Y., CHEN, F., MA, Y.L., ZHANG, X.B., BI, Y.Z. and CAO, Y.C. (2009) Effects of combinations of ochratoxin A and T-2 toxin on immune function of yellow-feathered broiler chickens. Poultry Science 88: 504-510.CrossRefGoogle ScholarPubMed
XU, J.X., CAO, C.Y., SUN, Y.C., WANG, L.L., LI, N., XU, S.W. and LI, J.L. (2014) Effects on liver hydrogen peroxide metabolism induced by dietary selenium deficiency or excess in chickens. Biological Trace Element Research 159: 174-182.Google Scholar
YANG, X.J., LI, W.L., FENG, Y. and YAO, J.H. (2011) Effects of immune stress on growth performance, immunity, and cecal microflora in chickens. Poultry Science 90: 2740-2746.Google Scholar
YAO, H., ZHAO, W., ZHAO, X., FAN, R., KHOSO, P.A., ZHANG, Z., LIU, W. and XU, S. (2014) Selenium deficiency mainly influences the gene expressions of antioxidative selenoproteins in chicken muscles. Biological Trace Element Research 161: 318-327.Google Scholar
YAO, L., DU, Q., YAO, H., CHEN, X., ZHANG, Z. and XU, S. (2015) Roles of oxidative stress and endoplasmic reticulum stress in selenium deficiency-induced apoptosis in chicken liver. Biometals 28: 255-265.Google Scholar
YUE, H.Y., WANG, J., QI, X.L., JI, F., LIU, M.F., WU, S.G., ZHANG, H.J. and QI, G.H. (2011) Effects of dietary oxidised oil on laying performance, lipid metabolism, and apolipoprotein gene expression in laying hens. Poultry Science 90: 1728-1736.Google Scholar
ZHANG, W., XIAO, S., LEE, E.J. and AHN, D.U. (2011) Consumption of oxidised oil increases oxidative stress in broilers and affects the quality of breast meat . Journal of Agricultural and Food Chemistry 59: 969-974.Google Scholar