Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-24T07:27:33.869Z Has data issue: false hasContentIssue false
  • English
  • Français

Development of bioceramic bone scaffolds by introducing triple liquid phases

Published online by Cambridge University Press:  11 October 2016

Cijun Shuai ,
Songlin Duan ,
Ping Wu ,
Dan Gao ,
Pei Feng ,
Chengde Gao  and
Shuping Peng
Cijun Shuai
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China; and State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China
Songlin Duan
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China
Ping Wu
Affiliation:
College of Chemistry, Xiangtan University, Xiangtan 411105, People's Republic of China
Dan Gao
Affiliation:
School of Basic Medical Science, Central South University, Changsha 410078, People's Republic of China
Pei Feng
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China
Chengde Gao
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China
Shuping Peng*
Affiliation:
Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410078, People's Republic of China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, People's Republic of China; and Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, People's Republic of China
*
a) Address all correspondence to this author. e-mail: shuping@csu.edu.cn
Get access

Abstract

In this study, a system of triple liquid phases was developed using Li2CO3, Na2CO3, and K2CO3 to improve the densification of the akermanite scaffolds fabricated by selective laser sintering (SLS). The system formed a ternary liquid phase (Li2CO3–Na2CO3–K2CO3) at 399 °C, a binary liquid phase (Na2CO3–K2CO3) at 695 °C, and a unitary liquid phase (K2CO3) at 891 °C during sintering process. The effects of the liquid phases on the sinterability and mechanical properties of the scaffolds were investigated. The fracture toughness and compressive strength is increased by 43 and 152% with liquid phases increasing from 0 to 4 wt%, respectively. This was explained that liquid phases enhanced densification via improving diffusion kinetics and inducing particle rearrangement. In addition, the scaffolds maintained favorable hydroxyapatite (HA) formation ability and cell proliferation ability, which was proved by simulated body fluid (SBF) test and microculture tetrazolium test (MTT), respectively.

Keywords

biomaterialdensificationlaser
Type
Articles
Information
Journal of Materials Research , Volume 31 , Issue 22 , 28 November 2016 , pp. 3498 - 3505
Check for updates
Copyright
Copyright © Materials Research Society 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Wang, H., Zhao, S., Cui, X., Pan, Y., Huang, W., Ye, S., Luo, S., Rahaman, M.N., Zhang, C., and Wang, D.: Evaluation of three-dimensional silver-doped borate bioactive glass scaffolds for bone repair: Biodegradability, biocompatibility, and antibacterial activity. J. Mater. Res. 30, 2722 (2015).Google Scholar
Gopi, D., Murugan, N., Ramya, S., Shinyjoy, E., and Kavitha, L.: Ball flower like manganese, strontium substituted hydroxyapatite/cerium oxide dual coatings on the AZ91 Mg alloy with improved bioactive and corrosion resistance properties for implant applications. RSC Adv. 5, 27402 (2015).Google Scholar
Gao, C., Zhuang, J., Li, P., Shuai, C., and Peng, S.: Preparation of micro/nanometer-sized porous surface structure of calcium phosphate scaffolds and the influence on biocompatibility. J. Mater. Res. 29, 1144 (2014).Google Scholar
Aminian, A., Pardun, K., Volkmann, E., Destri, G.L., Marletta, G., Treccani, L., and Rezwan, K.: Enzyme-assisted calcium phosphate biomineralization on an inert alumina surface. Acta Biomater. 13, 335 (2015).Google Scholar
Gu, B., Liu, F., Jiang, Y., and Zhang, K.: Evaluation of glass-forming ability criterion from phase-transformation kinetics. J. Non-Cryst. Solids 358, 1764 (2012).Google Scholar
Mohammadi, H., Sepantafar, M., and Ostadrahimi, A.: The role of bioinorganics in improving the mechanical properties of silicate ceramics as bone regenerative materials. J. Ceram. Sci. Technol. 6, 1 (2015).Google Scholar
Tian, T., Han, Y., Ma, B., Wu, C., and Chang, J.: Novel co-akermanite (Ca2CoSi2O7) bioceramics with the activity to stimulate osteogenesis and angiogenesis. J. Mater. Chem. B 3, 6773 (2015).Google Scholar
Perera, F.H., Martínez-Vázquez, F.J., Miranda, P., Ortiz, A.L., and Pajares, A.: Clarifying the effect of sintering conditions on the microstructure and mechanical properties of β-tricalcium phosphate. Ceram. Int. 36, 1929 (2010).Google Scholar
Sainz, M.A., Pena, P., Serena, S., and Caballero, A.: Influence of design on bioactivity of novel CaSiO3–CaMg(SiO3)2 bioceramics: In vitro simulated body fluid test and thermodynamic simulation. Acta Biomater. 6, 2797 (2010).Google Scholar
Shuai, C., Han, Z., Feng, P., Gao, C., Xiao, T., and Peng, S.: Akermanite scaffolds reinforced with boron nitride nanosheets in bone tissue engineering. J. Mater. Sci.: Mater. Med. 26, 1 (2015).Google Scholar
Feng, P., Gao, C., Shuai, C., and Peng, S.: Toughening and strengthening mechanisms of porous akermanite scaffolds reinforced with nano-titania. RSC Adv. 5, 3498 (2015).Google Scholar
Sharma, A.S., Mishra, N., Biswas, K., and Basu, B.: Densification kinetics, phase assemblage and hardness of spark plasma sintered Cu–10 wt% TiB2 and Cu–10 wt% TiB2–10 wt% Pb composites. J. Mater. Res. 28, 1517 (2013).CrossRefGoogle Scholar
German, R.M., Suri, P., and Park, S.J.: Review: Liquid phase sintering. J. Mater. Sci. 44, 1 (2009).Google Scholar
Ramesh, S., Tan, C.Y., Yeo, W.H., Tolouei, R., Amiriyan, M., Sopyan, I., and Teng, W.D.: Effects of bismuth oxide on the sinterability of hydroxyapatite. Ceram. Int. 37, 599 (2011).Google Scholar
Zou, J., Zhang, G.J., and Kan, Y.M.: Pressureless densification and mechanical properties of hafnium diboride doped with B4C: From solid state sintering to liquid phase sintering. J. Eur. Ceram. Soc. 30, 2699 (2010).Google Scholar
Ortiz, A.L., Borrero-López, O., Quadir, M.Z., and Guiberteau, F.: A route for the pressureless liquid-phase sintering of SiC with low additive content for improved sliding-wear resistance. J. Eur. Ceram. Soc. 32, 965 (2012).Google Scholar
Malik, M.A., Hashim, M.A., and Nabi, F.: Ionic liquids in supported liquid membrane technology. Chem. Eng. J. 171, 242 (2011).Google Scholar
Wei, W., Chen, K., and Ge, G.: Strongly coupled nanorod vertical arrays for plasmonic sensing. Adv. Mater. 25, 3863 (2013).Google Scholar
Azadbeh, M., Danninger, H., and Gierl-Mayer, C.: Particle rearrangement during liquid phase sintering of Cu–20Zn and Cu–10Sn–10Pb prepared from prealloyed powder. Powder Metall. 56, 342 (2013).Google Scholar
Kim, T.W., Ryu, S.C., Kim, B.K., Yoon, S.Y., and Park, H.C.: Porous hydroxyapatite scaffolds containing calcium phosphate glass-ceramics processed using a freeze/gel-casting technique. Met. Mater. Int. 20, 135 (2014).Google Scholar
Vahabzadeh, S., Hack, V.K., and Bose, S.: Lithium-doped β-tricalcium phosphate: Effects on physical, mechanical and in vitro osteoblast cell-material interactions. J. Biomed. Mater. Res., Part B (2015). doi: 10.1002/jbm.b.33485.Google Scholar
Ruiz-Navas, E.M., Delgado, M.L., and Torralba, J.M.: 2014 based MMCs: Properties improvement by (TiCN)p and trace additions. J. Mater. Sci. 41, 3735 (2006).Google Scholar
Zeng, Y.T., Fu, B., Tang, G.H., Zhang, L., and Qian, Y.F.: Effects of lithium on extraction socket healing in rats assessed with micro-computed tomography. Acta Odontol. Scand. 71, 1335 (2013).Google Scholar
Goldhahn, J., Féron, J-M., Kanis, J., Papapoulos, S., Reginster, J-Y., Rizzoli, R., Dere, W., Mitlak, B., Tsouderos, Y., and Boonen, S.: Implications for fracture healing of current and new osteoporosis treatments: An ESCEO consensus paper. Calcif. Tissue Int. 90, 343 (2012).Google Scholar
Rop, O., Mlcek, J., Jurikova, T., Neugebauerova, J., and Vabkova, J.: Edible flowers-a new promising source of mineral elements in human nutrition. Molecules 17, 6672 (2012).Google Scholar
Kirmani, M.Z., Sheikh Mohiuddin, F.N., Naqvi, I.I., and Zahir, E.: Determination of some toxic and essential trace metals in some medicinal and edible plants of Karachi city. J. Basic Appl. Sci. 7, 89 (2011).Google Scholar
Shuai, C., Gao, C., Nie, Y., Hu, A., Qu, H., and Peng, S.: Structural design and experimental analysis of a selective laser sintering system with nano-hydroxyapatite powder. J. Biomed. Nanotechnol. 6, 370 (2010).Google Scholar
Duan, S., Feng, P., Gao, C., Xiao, T., Yu, K., Shuai, C., and Peng, S.: Microstructure evolution and mechanical properties improvement in liquid-phase-sintered hydroxyapatite by laser sintering. Materials 8, 1162 (2015).Google Scholar
Kokubo, T., Kushitani, H., Sakka, S., Kitsugi, T., and Yamamuro, T.: Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W3. J. Biomed. Mater. Res. 24, 721 (1990).Google Scholar
Tarafder, S., Balla, V.K., Davies, N.M., Bandyopadhyay, A., and Bose, S.: Microwave-sintered 3D printed tricalcium phosphate scaffolds for bone tissue engineering. J. Tissue Eng. Regener. Med. 7, 631 (2013).Google Scholar
O'brien, F.J.: Biomaterials & scaffolds for tissue engineering. Mater. Today 14, 88 (2011).Google Scholar
Akkouch, A., Zhang, Z., and Rouabhia, M.: Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly(l-lactide-co-ε-caprolactone) scaffold. J. Biomater. Appl. 28, 922 (2014).Google Scholar
Wollmershauser, J.A., Feigelson, B.N., Gorzkowski, E.P., Ellis, C.T., Goswami, R., Qadri, S.B., Tischler, J.G., Kub, F.J., and Everett, R.K.: An extended hardness limit in bulk nanoceramics. Acta Mater. 69, 9 (2014).CrossRefGoogle Scholar
Hu, D., Li, Z., and Zhu, Y.: Effect of ZnF2–TiO2–SiO2 additions on the two-step sintering behavior and mechanical properties of sol–gel derived corundum abrasive. Ceram. Int. 42, 7373 (2016).Google Scholar
Chen, X., Ou, J., Wei, Y., Huang, Z., Kang, Y., and Yin, G.: Effect of MgO contents on the mechanical properties and biological performances of bioceramics in the MgO–CaO–SiO2 system. J. Mater. Sci.: Mater. Med. 21, 1463 (2010).Google Scholar