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Implementation of a Combined Association-Linkage Model for Quantitative Traits in Linear Mixed Model Procedures of Statistical Packages

Published online by Cambridge University Press:  21 February 2012

A. Leo Beem  and
Dorret I. Boomsma
A. Leo Beem*
Affiliation:
Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands. al.beem@psy.vu.nl
Dorret I. Boomsma
Affiliation:
Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
*
*Address for correspondence: A. L. Beem, Department of Biological Psychology, Vrije Universiteit, van der Boechortstraat 1, 1081 BT Amsterdam, the Netherlands.

Abstract

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A transmission disequilibrium test for quantitative traits which combines association and linkage analyses is currently available in several dedicated software packages. We describe how to implement such models in linear mixed model procedures that are available in widely used statistical packages such as SPSS. We also briefly mention a few extensions of the model that become naturally available once the model is implemented in such procedures.

Type
Special Section on Advances in Statistical Models and Methods
Information
Twin Research and Human Genetics , Volume 9 , Issue 3 , 01 June 2006 , pp. 325 - 333
Copyright
Copyright © Cambridge University Press 2006