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Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people

Published online by Cambridge University Press:  29 May 2017

Shih-Wei Lai ,
Cheng-Li Lin  and
Kuan-Fu Liao
Shih-Wei Lai
Affiliation:
College of Medicine, China Medical University, Taichung, Taiwan Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
Cheng-Li Lin
Affiliation:
College of Medicine, China Medical University, Taichung, Taiwan Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
Kuan-Fu Liao*
Affiliation:
College of Medicine, Tzu Chi University, Hualien, Taiwan Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung, Taiwan Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
*
Correspondence should be addressed to: Kuan-Fu Liao, Department of Internal Medicine, Taichung Tzu Chi General Hospital, No.66, Sec. 1, Fongsing Road, Tanzi District, Taichung City, 427, Taiwan. Phone: +886-4-2205-2121; Fax: 886-4-2203-3986. Email: kuanfuliaog@gmail.com
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Abstract

Background:

The purpose of this paper was to examine whether glaucoma could be a non-memory manifestation of Alzheimer's disease in older people.

Methods:

We conducted a population-based, retrospective, case-control study to analyze the database of the Taiwan National Health Insurance Program. There were 1,351 subjects ≥65 years old with newly diagnosed Alzheimer's disease as the cases, and 5,329 subjects without any type of dementias as the controls during 2000–2011. The odds ratio (OR) and 95% confidence interval (CI) for the risk of Alzheimer's disease associated with glaucoma was estimated by the multivariable unconditional logistic regression model.

Results:

After controlling for confounders, the multivariable logistic regression model demonstrated that the adjusted OR of Alzheimer's disease was 1.50 in subjects with glaucoma (95% CI 1.19, 1.89), compared to subjects without glaucoma.

Conclusions:

Older people with glaucoma are associated with 1.5-fold increased odds of Alzheimer's disease in Taiwan. Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people. Further research is needed to confirm this issue.

Keywords

Alzheimer's diseaseglaucomaolder peopleTaiwan national health insurance program
Type
Research Article
Information
International Psychogeriatrics , Volume 29 , Issue 9 , September 2017 , pp. 1535 - 1541
Copyright
Copyright © International Psychogeriatric Association 2017 

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