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Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection

Published online by Cambridge University Press:  09 June 2016

MAHDIS AGHAZADEH ,
MARINA C. HARVIE ,
HELEN C. OWEN ,
CAROLINA VERÍSSIMO ,
KIERAN V. ALAND ,
SIMON A. REID ,
REBECCA J. TRAUB ,
DONALD P. McMANUS ,
JAMES S. McCARTHY  and
MALCOLM K. JONES
MAHDIS AGHAZADEH*
Affiliation:
The University of Queensland, School of Veterinary Science, Gatton, Queensland 4343, Australia QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
MARINA C. HARVIE
Affiliation:
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
HELEN C. OWEN
Affiliation:
The University of Queensland, School of Veterinary Science, Gatton, Queensland 4343, Australia
CAROLINA VERÍSSIMO
Affiliation:
Laboratório de BiologiaParasitária e Parasitologia Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
KIERAN V. ALAND
Affiliation:
Queensland Museum and Sciencentre, Queensland 4101, Australia
SIMON A. REID
Affiliation:
The University of Queensland, School of Public Health, Herston, QLD 4006, Australia
REBECCA J. TRAUB
Affiliation:
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Victoria 3052, Australia
DONALD P. McMANUS
Affiliation:
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
JAMES S. McCARTHY
Affiliation:
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia The University of Queensland, School of Public Health, Herston, QLD 4006, Australia
MALCOLM K. JONES
Affiliation:
The University of Queensland, School of Veterinary Science, Gatton, Queensland 4343, Australia QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
*
*Corresponding author: Mahdis Aghazadeh, Faculty of Veterinary Science, School of Life and Environment Sciences, The University of Sydney, Camperdown, NSW 2050, Australia. Tel: +61293517083. E-mail: Mahdis.aghazadeh@sydney.edu.au
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Summary

This study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with Angiostrongylus mackerrasae and the closely related species A. cantonensis. Time course analyses showed that A. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. Both A. mackerrasae and the genetically similar A. cantonensis caused eosinophilic meningitis in mice at two time points of 14 and 21 days post infection (dpi). The brain lesions in mice infected with A. mackerrasae were more granulomatous in nature and the parasites were more likely to appear degenerate compared with lesions caused by A. cantonensis. This may indicate that the mouse immune system eliminates A. mackerrasae infection more effectively. The immunologic responses of mice infected with the two Angiostrongylus species was compared by assessing ex vivo stimulated spleen derived T cells and cytokines including interferon-gamma, interleukin 4 and interleukin 17 on 14 and 21 dpi. The results were similar for mice infected with A. cantonensis and A. mackerrasae. Serum from the infected animals with either A. cantonensis or A. mackerrasae recognized total soluble antigen of A. cantonensis female worms on Western blot.

Keywords

Angiostrongylus mackerrasaeAngiostrongylus cantonensisRattus fuscipesrat lungwormeosinophilic meningitisangiostrongyliasis
Type
Research Article
Information
Parasitology , Volume 143 , Issue 10 , September 2016 , pp. 1243 - 1251
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Copyright
Copyright © Cambridge University Press 2016 

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