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X-ray powder diffraction data for loratadine (C22H23ClN202)

Published online by Cambridge University Press:  03 March 2014

Di Wu
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Shan Shan Li
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Kai Lin Xu
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Li Li Zhang
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Xiao Qing Wu
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Hui Li*
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
*
a)Author to whom correspondence should be addressed. Electronic mail: lihuilab@sina.com

Abstract

X-ray powder diffraction data, unit-cell parameters, and space group for loratadine (C22H23ClN2O2) are reported [a = 28.302(18) Å, b = 4.996(3) Å, c = 29.154(19) Å, β = 109.158(2)°, unit-cell volume V = 3894.25 Å3, Z = 8, and space group C2/c]. All measured lines were indexed and are consistent with the C2/c space group. No detectable impurities were observed.

Type
New Diffraction Data
Copyright
Copyright © International Centre for Diffraction Data 2014 

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References

Engel, G. E., Wilke, S., König, O., Harris, K. D. M., and Leusen, F. J. J. (1999). “Powder solve-a complete package for crystal structure solution from powder diffraction patterns,” J. Appl. Crystallogr. 32, 11691179.Google Scholar
Ghosal, A., Gupta, S., Ramanathan, R., Yuan, Y., Lu, X. W., Su, A. D., Alvarez, N., Zbaida, S., Chowdhury, S. K., and Alton, K. B. (2009). “Metabolism of loratadine and further characterization of its in vitro metabolites,” Drug Metab. Lett. 3, 162170.Google Scholar
Haria, M., Fitton, A., and Peters, D. H. (1994). “Loratadine: a reappraisal of its pharmacological properties and therapeutic use in allergic disorders,” Drugs 48, 617637.Google Scholar
Kaminski, J. J., Carruthers, N. I., Wong, S. C., Chan, T. M., Billah, M. M., Tozzi, S., and McPhail, A. T. (1999). “Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine,” Bioorg. Med. Chem. 7, 14131423.Google Scholar
Pan, Q. Q., Guo, P., Duan, J., Cheng, Q., and Li, H. (2012). “Comparative crystal structure determination of griseofulvin: powder X-ray diffraction versus single-crystal X-ray diffraction,” Chin. Sci. Bull. 57, 38673871.Google Scholar
Young, R. A. (1993). The Rietveld Method, IUCr Monographies of Crystallography (Wiley, Oxford).Google Scholar