Hostname: page-component-8448b6f56d-mp689 Total loading time: 0 Render date: 2024-04-23T19:31:30.067Z Has data issue: false hasContentIssue false
  • English
  • Français

Preparation and characteristics of novel poly-L-lactide/β-calcium metaphosphate fracture fixation composite rods

Published online by Cambridge University Press:  31 January 2011

Li Liao ,
Lin Chen ,
Ai-Zheng Chen ,
Xi-Ming Pu ,
Yun-Qing Kang ,
Ya-Dong Yao ,
Xiao-Ming Liao ,
Zhong-bing Huang  and
Guang-Fu Yin
Li Liao
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Lin Chen
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Ai-Zheng Chen
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Xi-Ming Pu
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Yun-Qing Kang
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Ya-Dong Yao
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Xiao-Ming Liao
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Zhong-bing Huang
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Guang-Fu Yin*
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
*
a)Address all correspondence to this author. e-mail: nic0700@scu.edu.cn
Get access

Abstract

A kind of novel poly-L-lactide (PLLA)/β-calcium metaphosphate (β-CMP) fracture-fixation composite rod was prepared by a two-step compression-molding method. The in vitro bioactivity of the composite rod was evaluated by investigating the effects of dissolved products from the composite rod on osteoblasts. In addition, the in vitro biocompatibility of the composite rod was evaluated by an osteoblast adhesion-and-proliferation assay. The products from composite rod dissolution significantly promoted cell growth. Furthermore, osteoblasts adhered and spread well on the rod. This PLLA/β-CMP composite rod has potential applications for clinical use following the assessment of adaptation during in vivo studies.

Keywords

CMPCompositeStrength
Type
Articles
Information
Journal of Materials Research , Volume 22 , Issue 12 , December 2007 , pp. 3324 - 3329
Copyright
Copyright © Materials Research Society 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1Ager, J.W. III, Balooch, G.Ritchie, R.O.: Fracture, aging, and disease in bone. J. Mater. Res. 21, 1878 2006CrossRefGoogle Scholar
2Head, W.C., Bauk, D.J.Emerson, R.H.: Titanium as the material of choice for cementless femoral components in total hip arthroplasty. Clin. Orthop. Rel. Res. 311, 85 1995Google Scholar
3Hu, Q-L., Li, B-Q., Wang, M.Shen, J-C.: Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: A potential material as internal fixation of bone fracture. Biomaterials 25, 779 2004CrossRefGoogle ScholarPubMed
4Hasegawa, S., Ishii, S., Tamura, J., Furukawa, T., Neo, M., Matsusue, Y., Shikinami, Y., Okuno, M.Nakamura, T.: A 5–7 year in vivo study of high-strength hydroxyapatite/poly (L-lactide) composite rods for the internal fixation of bone fractures. Biomaterials 27, 1327 2006CrossRefGoogle ScholarPubMed
5Böstman, O.Pihlajamäki, H.: Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: A review. Biomaterials 21, 2615 2000CrossRefGoogle ScholarPubMed
6Middleton, J.C.Tipton, A.J.: Synthetic biodegradable polymers as orthopedic devices. Biomaterials 21, 2335 2000CrossRefGoogle ScholarPubMed
7Furukawa, T., Matsusue, Y., Yasunaga, T., Shikinami, Y., Okuno, M., Nakamura, T.: Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures. Biomaterials 21, 889 2000CrossRefGoogle ScholarPubMed
8Shikinami, Y., Matsusue, Y.Nakamura, T.: The complete process of bioresorption and bone replacement using devices made of forged composites of raw hydroxyapatite particles/poly L-lactide (F-u-HA/PLLA). Biomaterials 26, 5542 2005CrossRefGoogle ScholarPubMed
9Jung, Y., Kim, S.S., Kim, Y.H., Kim, S.H., Kim, B.S., Kim, S., Choi, C.Y.Kim, S.H.: A poly (lactic acid)/calcium metaphosphate composite for bone tissue engineering. Biomaterials 26, 6314 2005CrossRefGoogle ScholarPubMed
10Jaw, K-S.: The effects on the devitrification mechanism for a certain composition of CaO/P2O5 glass with additives of HAp, TCP, and β-CaP2O6 whisker. J. Therm. Anal. Cal. 83, 151 2006CrossRefGoogle Scholar
11Thomson, R.C., Yaszemski, M.J., Powers, J.M.Mikos, A.G.: Hydroxyapatite fiber reinforced poly (a-hydroxy ester) foams for bone regeneration. Biomaterials 19, 1935 1998CrossRefGoogle Scholar
12Bleach, N.C., Nazhat, S.N., Tanner, K.E., Kellomäki, M.Törmälä, P.: Effect of filler content on mechanical and dynamic mechanical properties of particulate biphasic calcium phosphate polylactide composites. Biomaterials 23, 1579 2002CrossRefGoogle ScholarPubMed
13Ambrosio, A.M., Sahota, J.S., Khan, Y.Laurencin, C.T.: A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization. J. Biomed. Mater. Res. Appl. Biomater. 58, 295 20013.0.CO;2-8>CrossRefGoogle ScholarPubMed
14Lee, S.H., Kim, B-S., Kim, S.H., Jeong, S.I., Kang, S.W.Kim, Y.H.: Thermally produced biodegradable scaffolds for cartilage tissue engineering. Macromol. Biosci. 4, 802 2004CrossRefGoogle ScholarPubMed
15Chen, L., Liao, L., Yin, G-F., Chen, A-Z.Pu, X-M.: Preparation and strength properties of poly-L-lactide(PLLA)/β-calcium metaphosphate (β-CMP) composite for internal fracture fixation. J. Funct. Mater. 37, 1466 2006Google Scholar
16Ishaug, S.L., Yaszemski, M.J., Bizios, R.Mikos, A.G.: Osteoblast function on synthetic biodegradable polymers. J. Biomed. Mater. Res. 28, 1445 1994CrossRefGoogle ScholarPubMed
17Hirst, R.A., Yesilkaya, H., Clitheroe, E., Rutman, A., Dufty, N., Mitchell, T.J., Callaghan, C.O.Andrew, P.W.: Sensitivities of human monocytes and epithelial cells to pneumolysin are different. Infect. Immun. 70, 1017 2002CrossRefGoogle ScholarPubMed
18Shikinami, Y.Okuno, M.: Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): Part I. Basic characteristics. Biomaterials 20, 859 1999CrossRefGoogle Scholar
19Hench, L.L.: Bioceramics. J. Am. Ceram. Soc. 81, 1705 1998CrossRefGoogle Scholar