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Development of new sol-gel derived Ag-doped biomaterials for dental applications

Published online by Cambridge University Press:  19 April 2012

Xanthippi Chatzistavrou
Affiliation:
Department of Frontier Materials, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan
Eleana Kontonasaki
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Athina Bakopoulou
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Anna Theocharidou
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Afroditi Sivropoulou
Affiliation:
Biology Department, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Konstantinos M. Paraskevopoulos
Affiliation:
Department of Physics Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Petros Koidis
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Aldo R. Boccaccini
Affiliation:
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany
Toshihiro Kasuga
Affiliation:
Department of Frontier Materials, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan
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Abstract

The aim of this work was to develop a new Ag-doped bioactive material with antibacterial behavior, optimizing the properties of the new fabricated composite material in the system SiO2 58.6 -P2O5 7.2 -Al2O3 4.2 -CaO 24.9 -Na2O 2.1 -K2O 3 (wt%). Two systems with different concentrations in Ag2O (Ba with 2.1 and Bb with 4.2 wt%) were prepared by the sol-gel method and compared to the respective silver-free control composite (CONTROL). The microstructural characteristics of the developed compositions were characterized by different techniques as UV/VIS spectroscopy, X-ray diffraction analysis (XRD) and Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM-EDS). The antibacterial properties of the Ag-doped glass-ceramics were tested against the bacterial colony Staphylococcus aureus (S. aureus) which is very characteristic oral bacteria and the material-cell interaction was monitored in a primary culture of Human Gingival Fibroblasts (HGFs). Our study shows the successful incorporation of the silver ions in the ceramic structure and the preparation of new Ag-doped composite materials with cell-proliferation-inductive, as well as antibacterial properties indicating their potential application dental tissue restoration strategies.

Type
Research Article
Copyright
Copyright © Materials Research Society 2012

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References

REFERENCES

1. Kawashita, M., Tsuneyama, S., Miyaji, F., Kokubo, T. et al. . Biomaterials 21, 393 (2000).Google Scholar
2. Chatzistavrou, X., Esteve, D., Hatzistavrou, E., Kontonasaki, E. et al. . Mater. Sci. Eng. C 30, 730 (2010).Google Scholar
3. Saravanapava, P., Gough, J.E., Jones, J.R., Hench, L.L., Key Eng. Mater. 254-256, 1087 (2004).Google Scholar
4. Hillmann, G., Steinkamp-Zucht, A., Geurtsen, W., Gross, G. et al. . Biomaterials 23, 1461 (2002).Google Scholar