Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-24T17:40:03.108Z Has data issue: false hasContentIssue false
  • English
  • Français

New Nanocomposite Biomaterials Controlling Surface and Bulk Properties using Supercritical Carbon Dioxide

Published online by Cambridge University Press:  01 February 2011

Toru Hoshi ,
Takashi Sawagushi ,
Ryosuke Matsuno ,
Tomohiro Konno ,
Madoka Takai  and
Kazuhiko Ishihara
Toru Hoshi
Affiliation:
hoshi@mpc.t.u-tokyo.ac.jp, The University of Tokyo, Department of Materials Engineering, School of Engineering, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan, +81-3-5841-7124, +81-3-5841-8647
Takashi Sawagushi
Affiliation:
sawaguti@chem.cst.nihon-u.ac.jp, Nihon University, Department of Materials and Applied Chemistry, College of Science and Technology, 1-8-14, Kanda Surugadai, Chiyoda-ku,, Tokyo, 101-8308, Japan
Ryosuke Matsuno
Affiliation:
matsuno@mpc.t.u-tokyo.ac.jp, The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
Tomohiro Konno
Affiliation:
konno@mpc.t.u-tokyo.ac.jp, The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
Madoka Takai
Affiliation:
takai@mpc.t.u-tokyo.ac.jp, The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
Kazuhiko Ishihara
Affiliation:
ishihara@mpc.t.u-tokyo.ac.jp, The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
Get access

Abstract

The molecular composite composed of polyethylene (PE) and poly(vinyl acetate) (PVAc) prepared using supercritical carbon dioxide (scCO2) and its surface modification for biocompatible surface demonstrated the creation of novel polymer biomaterials. In this study, this modification process was applied to the PE narrow tube (inside diameter: 300μm, outside diameter: 600μm, length: 5m). It was confirmed that PVAc was uniformly generated in PE tube by infrared imaging measurement of cross-section. After the acetyl group on the surface was hydrolyzed, phospholipid polymer was immobilized to the hydroxyl group on the surface of the tube. The phospholipid polymer immobilized surface showed a drastic reduction in protein adsorption. The surface of the minute and slender tube can be effectively modified using the feature of carbon dioxide whose surface tension is near zero. The modification technology by scCO2 is a promising for creation of variously-shaped new biomaterials.

Keywords

biomaterialpolymerinfrared (IR) spectroscopy
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1097: Symposium GG – Mechanical Behavior of Biological Materials and Biomaterials , 2008 , 1097-GG04-15
Copyright
Copyright © Materials Research Society 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Rantner, B.D., Hoffman, A.S., Schoen, F.J., Lemons, J.E., Biomaterials Science: An Introduction to Materials in Medicine, Academic Press, 1996.Google Scholar
2 Hoshi, T., Sawaguchi, T., Matsuno, R., Konno, T., Takai, M., Ishihara, K., J. Supercritical Fluids. 44, 391 (2008)Google Scholar
3 Hoshi, T., Sawaguchi, T., Konno, T., Takai, M., Ishihara, K., Polymer. 48, 1573 (2007)Google Scholar
4 Hoshi, T., Sawaguchi, T., Matsuno, R., Konno, T., Takai, M., Ishihara, K., Applied Surface Science, in press (2008)Google Scholar
5 Xu, Y., Takai, M., Konno, T., Ishihara, K., Lab. Chip. 7, 199 (2007)Google Scholar
6 Ishihara, K., Sci. Tech. Adv. Mater. 1, 131 (2000).Google Scholar