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Combined use of chemical and biological compounds to control hookworm

Published online by Cambridge University Press:  01 June 2020

J.A.C. Lima Open the ORCID record for J.A.C. Lima [Opens in a new window] ,
C.M. Ferraz Open the ORCID record for C.M. Ferraz [Opens in a new window] ,
M.R.d.A. Lima Open the ORCID record for M.R.d.A. Lima [Opens in a new window] ,
H.L.A. Genier Open the ORCID record for H.L.A. Genier [Opens in a new window] ,
F.E.d.F. Soares Open the ORCID record for F.E.d.F. Soares [Opens in a new window] ,
D.B.L. Junior Open the ORCID record for D.B.L. Junior [Opens in a new window] ,
S.A. Sobral Open the ORCID record for S.A. Sobral [Opens in a new window] ,
J.V. de Araújo Open the ORCID record for J.V. de Araújo [Opens in a new window] ,
F.L. Tobias Open the ORCID record for F.L. Tobias [Opens in a new window]  and
V.L.R. Vilela Open the ORCID record for V.L.R. Vilela [Opens in a new window]
...Show all authors
J.A.C. Lima
Affiliation:
Pharmaceutical Science Graduate Program, Universidade Vila Velha – UVV, Minas Gerais, Brazil
C.M. Ferraz
Affiliation:
Pharmaceutical Science Graduate Program, Universidade Vila Velha – UVV, Minas Gerais, Brazil
M.R.d.A. Lima
Affiliation:
Pharmaceutical Science Graduate Program, Universidade Vila Velha – UVV, Minas Gerais, Brazil
H.L.A. Genier
Affiliation:
Instituto Federal do Espírito Santo – IFES, Espírito Santo, Brazil
F.E.d.F. Soares
Affiliation:
Chemistry Department, Universidade Federal de Lavras – UFLA, Minas Gerais, Brazil
D.B.L. Junior
Affiliation:
Pharmaceutical Science Graduate Program, Universidade Vila Velha – UVV, Minas Gerais, Brazil
S.A. Sobral
Affiliation:
Pharmaceutical Science Graduate Program, Universidade Vila Velha – UVV, Minas Gerais, Brazil
J.V. de Araújo
Affiliation:
Department of Veterinary Medicine, Universidade Federal de Viçosa, Minas Gerais, Brazil
F.L. Tobias
Affiliation:
Pharmaceutical Science Graduate Program, Universidade Vila Velha – UVV, Minas Gerais, Brazil
V.L.R. Vilela*
Affiliation:
Department of Veterinary Medicine, Instituto Federal da Paraíba – IFPB, Paraíba, Brazil
F.R. Braga
Affiliation:
Pharmaceutical Science Graduate Program, Universidade Vila Velha – UVV, Minas Gerais, Brazil
*
Author for correspondence: V.L.R. Vilela, E-mail: vinicius.vilela@ifpb.edu.br
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Abstract

The aim of this study was to evaluate the combined use of different chemical (albendazole, ivermectin, glycerine and Vaseline) and biological (Monacrosporium thaumasium) compounds in the control of Ancylostoma caninum. Infective larvae of A. caninum were obtained from coprocultures of positive faeces from naturally infected dogs. We used 1% ivermectin, 1% albendazole, 100% glycerine, 100% Vaseline and an isolate of the nematophagous fungus M. thaumasium (NF34), alone or in combinations. Next, an experimental test was set up with 16 groups in microtubes, with a 24-h interaction. The groups (G1 to G15) that contained any chemical or biological compound (NF34) and/or their combined use (chemical + biological) showed a difference in relation to the control group, except G5 – Vaseline 100% without combinations. It was concluded that, even on an experimental basis, the combined use of anthelmintic drugs with biological control was efficient; however, more studies must be carried out in order to elucidate the synergistic action between chemical and biological compounds to be used in the effective control of hookworms in the future.

Keywords

Ancylostoma caninumbiological controlpublic health
Type
Short Communication
Information
Journal of Helminthology , Volume 94 , 2020 , e160
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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Footnotes

*

CNPq Scholarship.

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