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In vitro Evaluation of Macrophage Adhesion and Proliferation on Alumina

Published online by Cambridge University Press:  01 February 2011

Peishan Liu-Snyder  and
Thomas J. Webster
Peishan Liu-Snyder
Affiliation:
peishan@brown.edu, Brown University, Division of Engineering, 184 Hope Street,, Providence, RI, 02906, United States, 4018631419
Thomas J. Webster
Affiliation:
Thomas_Webster@brown.edu, Brown University, Division of Engineering, 184 Hope Street, Providence, RI, 02912, United States
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Abstract

Extensive interactions of inflammatory cells (such as macrophages) with biomaterials at the host-implant interface are often blamed for failure of implanted biomedical devices [1]. While previous studies have shown increased in vitro and in vivo bone cell (osteoblast) responses on nanophase ceramics [2], few (if any) studies have been conducted to elucidate inflammatory cell responses on such novel materials. In this study, we reported that macrophage adhesion and proliferation on nanophase (97.7 nm grain size) alumina (Al2O3) was significantly less than conventional (187.4 nm grain size) alumina, respectively, after 4, 12, 24 h. The present study provides evidence of the ability of nanophase alumina to down-regulate macrophage adhesion and proliferation, which is imperative for the future consideration of nanophase materials for orthopedic and dental applications.

Keywords

adhesionnanostructurebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D15-05
Copyright
Copyright © Materials Research Society 2007

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References

REFERENCES

1. Gristina, A.G., Clin Orthop Relat Res. 298, 106 (1994).Google Scholar
2. Webster, T. J., Tissue Eng. 7, 291 (2001).Google Scholar
3. Lee, S. J., “Alumina.” Encyclopedia of Biomaterials and Biomedical Engineering. Wnek, G. and Bowlin, G. L. (Marcel Dekker, 2004) pp. 19–27.Google Scholar
4. Purdue, P. E., Koulouvaris, P., Potter, H. G., Nestor, B. J., Sculco, T. P., Clin Orthop Relat Res. 2006 Sep 14; [Epub ahead of print].Google Scholar
5. Robling, A. G., Castillo, A. B., Turner, C. H., Annu Rev Biomed Eng. 8, 455 (2006).Google Scholar
6. Price, R. L., Gutwein, L. G., Kaledin, L., Tepper, F., Webster, T. J.. J Biomed Mater Res A. 67, 1284 (2003).Google Scholar
7. Webster, T. J., J Biomed Mater Res. 5, 475 (2000).Google Scholar
8. Wu, S. J., J Am Ceram Soc. 79, 2207 (1996).Google Scholar
9. Webster, T. J.. Siegel, R. W. and Bizios, R., Biomaterials. 20, 1221 (1999).Google Scholar
10. Weise, L. and Glaves, D., J. Immunol. 115, 1362 (1975).Google Scholar
11. Cohen, Z. A., J. Immunol. 121, 813 (1978).Google Scholar