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Dynamics of heart rate variability analysed through nonlinear and linear dynamics is already impaired in young type 1 diabetic subjects

Published online by Cambridge University Press:  03 February 2016

Naiara M. Souza ,
Thais R. Giacon ,
Francis L. Pacagnelli ,
Marianne P. C. R. Barbosa ,
Vitor E. Valenti  and
Luiz C. M. Vanderlei
Naiara M. Souza*
Affiliation:
Faculdade de Ciências e Tecnologia – FCT/UNESPPresidente Prudente, Marília, SP, Brazil
Thais R. Giacon
Affiliation:
Faculdade de Ciências e Tecnologia – FCT/UNESPPresidente Prudente, Marília, SP, Brazil
Francis L. Pacagnelli
Affiliation:
Universidade do Oeste Paulista – UNOESTE, Presidente Prudente, Marília, SP, Brazil
Marianne P. C. R. Barbosa
Affiliation:
Faculdade de Ciências e Tecnologia – FCT/UNESPPresidente Prudente, Marília, SP, Brazil
Vitor E. Valenti
Affiliation:
Faculdade de Filosofia e Ciências – FFC/UNESP, Marília, SP, Brazil
Luiz C. M. Vanderlei
Affiliation:
Faculdade de Ciências e Tecnologia – FCT/UNESPPresidente Prudente, Marília, SP, Brazil
*
Correspondence to: N. M. Souza, Roberto Simonsen Street, 305 - Presidente Prudente, SP 19060-900, Brazil. Tel: +55 18 3229-5819; Fax: +55 18 3221-4391; E-mail: naiara_bs@live.com
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Abstract

Background

Autonomic diabetic neuropathy is one of the most common complications of type 1 diabetes mellitus, and studies using heart rate variability to investigate these individuals have shown inconclusive results regarding autonomic nervous system activation.

Aims

To investigate the dynamics of heart rate in young subjects with type 1 diabetes mellitus through nonlinear and linear methods of heart rate variability.

Methods

We evaluated 20 subjects with type 1 diabetes mellitus and 23 healthy control subjects. We obtained the following nonlinear indices from the recurrence plot: recurrence rate (REC), determinism (DET), and Shanon entropy (ES), and we analysed indices in the frequency (LF and HF in ms2 and normalised units – nu – and LF/HF ratio) and time domains (SDNN and RMSSD), through analysis of 1000 R–R intervals, captured by a heart rate monitor.

Results

There were reduced values (p<0.05) for individuals with type 1 diabetes mellitus compared with healthy subjects in the following indices: DET, REC, ES, RMSSD, SDNN, LF (ms2), and HF (ms2). In relation to the recurrence plot, subjects with type 1 diabetes mellitus demonstrated lower recurrence and greater variation in their plot, inter-group and intra-group, respectively.

Conclusion

Young subjects with type 1 diabetes mellitus have autonomic nervous system behaviour that tends to randomness compared with healthy young subjects. Moreover, this behaviour is related to reduced sympathetic and parasympathetic activity of the autonomic nervous system.

Keywords

Diabetes mellitus type 1autonomic nervous systemnonlinear dynamicsheart rate and young adult
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 7 , October 2016 , pp. 1383 - 1390
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Copyright
© Cambridge University Press 2016 

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